"We are in the midst of a revolution in the application of SAXS
to the analysis of large molecular complexes”
- Nagar and Kuriyan (Structure 2005)
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~ February 24-26, 2012 ~
BioSAXS is a solution-based x-ray scattering technique that can yield valuable structural information on biomolecules such as the size, low-resolution shape, degree of folding, and oligomeric state.
This practical course for molecular biologists will focus on collecting, processing, and publishing BioSAXS data.
No previous x-ray experience necessary.
Students will have the opportunity to collect data on CHESS beamlines using protein standards and/or their own samples.
Processing software, installation help, and tutorials will be provided.
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Course topics:
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basic principles and processing methods
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sample preparation tips
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evaluating data quality
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computing envelopes and data modeling
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overview of advanced and emerging methods
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what you need to know for publication
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Lecturers: R. Gillilan (MacCHESS), S. Nielsen (Danish Technical University), K. Gupta (UPENN Medical School), M. Moller (University of Copenhagen), T. Grant (HWI), N. Ando (MIT), and L. Pollack (Cornell)
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