| Depart Boston on Congress St (South) for 98 yds |
| Bear RIGHT (South) onto Congress St [Post Office Sq] for 98 yds |
| Bear LEFT (South) onto Congress St for 0.2 mi |
| Take Ramp (RIGHT) onto I-93 [US-1] for 0.5 mi towards I-93 / I-90 West / Quincy / Worcester |
| At exit 20, turn LEFT onto Ramp for 0.2 mi towards I-90 / Worcester / Albany St |
| *Toll road* Merge onto I-90 [Mass Pike] for 151.6 mi |
| Entering New York |
| *Toll road* At exit B1, road name changes to Gov Thomas E Dewey Thruway [New York State Thruway] for 4.5 mi |
| *Toll road* Road name changes to Berkshire Spur [Gov Thomas E Dewey Thruway] for 1.0 mi |
| *Toll road* Road name changes to Castleton on Hudson Bridge [Gov Thomas E Dewey Thruway] for 0.6 mi |
| *Toll road* Road name changes to Gov Thomas E Dewey Thruway [New York State Thruway] for 0.5 mi |
| *Toll road* Keep STRAIGHT onto Ramp for 43 yds |
| *Toll road* Take Ramp (RIGHT) onto I-87 [Gov Thomas E Dewey Thruway] for 15.3 mi towards I-87 / I-90 / Albany / Buffalo |
| *Toll road* Merge onto I-90 [Gov Thomas E Dewey Thruway] for 127.5 mi |
| At exit 34A, turn RIGHT onto Ramp for 0.8 mi towards I-481 / Syracuse / Oswego |
| Take Ramp (LEFT) onto I-481 for 9.8 mi towards I-481 / Syracuse / Cortland |
| Take Ramp (LEFT) onto I-81 for 27.4 mi towards I-81 / Binghamton |
| At exit 12, turn RIGHT onto Ramp for 0.4 mi towards US-11 / Homer / Cortland |
| Keep LEFT to stay on Ramp for 87 yds |
| Keep RIGHT to stay on Ramp for 0.4 mi |
| Keep LEFT to stay on Ramp for 65 yds |
| Turn LEFT (South) onto SR-281 [W Homer Rd] for 1.1 mi |
| Keep STRAIGHT onto SR-281 [West Rd] for 2.7 mi |
| Keep STRAIGHT onto SR-13 for 7.6 mi |
| Turn RIGHT (West) onto SR-13 [W Main St] for 6.0 mi |
| Turn LEFT (South) onto SR-366 [Dryden Rd] for 3.6 mi |
| Turn RIGHT at 4 way stop into Wilson Lab Parking Lot |
