| Depart Long Island on Local road(s) (South-East) for 0.4 mi |
| Bear LEFT (East) onto Hopkins Commons for 98 yds |
| Turn RIGHT (South) onto Franklin Commons, then immediately turn RIGHT (South) onto Colonial Woods Dr W for 0.5 mi |
| Turn LEFT (East) onto Yaphank Woods Blvd for 0.4 mi |
| Turn RIGHT (South) onto CR-46 [William Floyd Pkwy] for 0.5 mi |
| Take Ramp (RIGHT) onto Long Island Expy N for 0.5 mi towards I-495 W / New York |
| Take Ramp onto I-495 [Long Island Expy] for 46.2 mi towards I-495 |
| At exit 31N-S, turn RIGHT onto Ramp for 0.2 mi towards Cross is Pkwy / Whitestone Br / Kennedy Airport |
| Take Ramp (RIGHT) onto Cross Island Pkwy for 3.4 mi towards Cross is Pkwy North / Whitestone Br |
| At exit 33, take Ramp (RIGHT) onto I-295 [Throgs Neck Bridge] for 5.0 mi towards I-295 / Throgs Neck Br / Bronx / New England |
| Road name changes to I-95 [Cross Bronx Expy] for 7.3 mi |
| Entering New Jersey |
| Keep LEFT onto I-95 Express Ln [New Jersey Tpke] for 2.5 mi towards I-95 South Express / New Jersey Turnpike South / I-80 / Garden State Parkway / Paterson |
| At exit 69, take Ramp (LEFT) onto I-80 Express Ln for 4.0 mi towards I-80 / Garden State Parkway / Paterson |
| Merge onto I-80 for 19.2 mi |
| Take Ramp onto I-80 Express Ln for 1.7 mi towards I-80 West Express |
| Road name changes to I-80 for 61.4 mi |
| Entering Pennsylvania |
| At exit 293, take Ramp (RIGHT) onto I-380 for 27.6 mi towards I-380 / Scranton |
| Turn off onto Ramp for 0.2 mi |
| Keep RIGHT to stay on Ramp for 0.4 mi towards I-81 / US-6 / Binghamton |
| Take Ramp onto I-81 for 74.3 mi |
| Entering New York |
| At exit 8, turn RIGHT onto Ramp for 0.2 mi towards RT-26 / US-11 / RT-79 / RT-206 / Whitney Point / Lisle |
| Turn RIGHT (North) onto SR-26 for 0.6 mi |
| Turn LEFT (North) onto US-11 [SR-26] for 2.0 mi |
| Turn LEFT (South-West) onto Local road(s) for 32 yds |
| At US-11, return North-East on Local road(s) for 32 yds |
| Turn LEFT (West) onto US-11 [SR-79] for 0.3 mi |
| Keep STRAIGHT onto SR-79 [Main St] for 7.5 mi |
| At SR-79, stay on SR-79 (West) for 18.8 mi |
| Bear RIGHT (North) onto CR-174 [Pine Tree Rd] for 1.0 mi |
| Road name changes to Pine Tree Rd for 0.6 mi |
| At 4 Way Stop go straight and you will be entering Wilson Lab Parking Lot |
