| Depart University of Pennsylvania [235 S 33rd St, Philadelphia PA 19104, (215) 898-6121] on Curie Blvd (West) for 0.2 mi |
| Turn LEFT (South) onto S University Ave for 0.2 mi |
| Take Ramp (RIGHT) onto I-76 [Schuylkill Expy] for 14.1 mi towards I-76 |
| At exit 331B, take Ramp onto I-476 [Blue Route] for 3.8 mi towards I-476 / Plymouth MTG |
| *Toll road* At exit 20, stay on I-476 [Blue Route] (North-East) for 111.7 mi |
| Keep RIGHT onto Ramp [Clarks Summit Interchange] for 0.2 mi towards I-81 / Binghamton / Wilkes Barre |
| Take Ramp (LEFT) onto I-81 for 85.5 mi towards I-81 Reconstruction near Scranton (NB) (August 3, 2007 - November 28, 2008) |
| Entering New York |
| Turn LEFT (West) onto Local road(s) for 32 yds |
| Turn LEFT (South) onto I-81 for 15.4 mi Construction near Marathon (SB) (July 3, 2006 - June 10, 2010) |
| At exit 8, turn RIGHT onto Ramp for 0.3 mi towards RT-79 / US-11 / RT-26 / RT-206 / Whitney Point / Lisle |
| Turn RIGHT (North-West) onto US-11 [SR-79] for 1.2 mi |
| Keep STRAIGHT onto SR-79 [Main St] for 11.8 mi |
| At SR-79, stay on SR-79 (West) for 14.4 mi |
| Bear RIGHT (North) onto CR-174 [Pine Tree Rd] for 1.0 mi |
| Road name changes to Pine Tree Rd for 0.6 mi |
| At 4 way stop go straight into Wilson Lab Parking Lot |
