|
Valid 05/2001 - 07/2001
Sigma Chemical Co.
P.O. Box 14508
St. Louis, MO 63178 USA
Tel: 314-771-5765
M A T E R I A L S A F E T Y D A T A S H E E T
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
CATALOG #: B9645
NAME: BORIC ACID PLANT CELL CULTURE TESTED
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
CAS #: 10043-35-3
MF: H3BO3
EC NO: 233-139-2
SYNONYMS
BASILIT B * BORACIC ACID * BOROFAX * BORON TRIHYDROXIDE * BORSAURE
(GERMAN) * DR.'S 1 FLEA TERMINATOR DF * DR.'S 1 FLEA TERMINATOR DFPBO
* DR.'S 1 FLEA TERMINATOR DT * DR.'S 1 FLEA TERMINATOR DTPBO * FLEA
PRUFE * NCI-C56417 * ORTHOBORIC ACID * SUPER FLEA ELIMINATOR * THREE
ELEPHANT * TRIHYDROXYBORONE *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
LABEL PRECAUTIONARY STATEMENTS
HARMFUL
POSSIBLE RISK OF HARM TO THE UNBORN CHILD.
POSSIBLE RISK OF IMPAIRED FERTILITY.
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
TARGET ORGAN(S):
CENTRAL NERVOUS SYSTEM
KIDNEYS
IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE.
WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE
PROTECTION.
DO NOT BREATHE DUST.
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
CALL A PHYSICIAN.
IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
IN CASE OF CONTACT, IMMEDIATELY WASH SKIN WITH SOAP AND COPIOUS
AMOUNTS OF WATER.
IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES WITH COPIOUS AMOUNTS OF
WATER FOR AT LEAST 15 MINUTES.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
EXTINGUISHING MEDIA
CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
WATER SPRAY.
SPECIAL FIREFIGHTING PROCEDURES
WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
PREVENT CONTACT WITH SKIN AND EYES.
UNUSUAL FIRE AND EXPLOSIONS HAZARDS
EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
EVACUATE AREA.
WEAR SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY
RUBBER GLOVES.
SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL.
AVOID RAISING DUST.
VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
WEAR APPROPRIATE NIOSH/MSHA-APPROVED RESPIRATOR, CHEMICAL-RESISTANT
GLOVES, SAFETY GOGGLES, OTHER PROTECTIVE CLOTHING.
USE ONLY IN A CHEMICAL FUME HOOD.
SAFETY SHOWER AND EYE BATH.
DO NOT BREATHE DUST.
DO NOT GET IN EYES, ON SKIN, ON CLOTHING.
AVOID PROLONGED OR REPEATED EXPOSURE.
WASH THOROUGHLY AFTER HANDLING.
WASH CONTAMINATED CLOTHING BEFORE REUSE.
KEEP TIGHTLY CLOSED.
STORE IN A COOL DRY PLACE.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
PHYSICAL PROPERTIES
MELTING POINT: 160 C
VAPOR PRESSURE: 2.6 MMHG
SPECIFIC GRAVITY: 1.435
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
INCOMPATIBILITIES
REACTS VIOLENTLY WITH:
SENSITIVE TO MOISTURE
POTASSIUM
ACID ANHYDRIDES
HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
BORON OXIDES.
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
ACUTE EFFECTS
TOXICITY REPORTED FOR BORATES IN HUMANS: INGESTION OR ABSORPTION
MAY CAUSE NAUSEA, VOMITING, DIARRHEA, ABDOMINAL CRAMPS, ERYTHEMATOUS
LESIONS ON THE SKIN AND MUCOUS MEMBRANES. OTHER SYMPTOMS INCLUDE:
CIRCULATORY COLLAPSE, TACHYCARDIA, CYANOSIS, DELIRIUM, CONVULSIONS AND
COMA. DEATH HAS BEEN REPORTED TO OCCUR IN INFANTS FROM LESS THAN
5 GRAMS AND IN ADULTS FROM 5 TO 20 GRAMS.
MATERIAL IS IRRITATING TO MUCOUS MEMBRANES AND UPPER
RESPIRATORY TRACT.
MAY BE HARMFUL BY INHALATION, INGESTION, OR SKIN ABSORPTION.
CAUSES EYE AND SKIN IRRITATION.
CHRONIC EFFECTS
POSSIBLE RISK OF CONGENITAL MALFORMATION IN THE FETUS.
OVEREXPOSURE MAY CAUSE REPRODUCTIVE DISORDER(S) BASED ON TESTS WITH
LABORATORY ANIMALS.
TARGET ORGAN(S):
CENTRAL NERVOUS SYSTEM
KIDNEYS
TESTES
RTECS #: ED4550000
BORIC ACID
IRRITATION DATA
SKN-HMN 15 MG/3D-I MLD 85DKA8 -,127,1977
TOXICITY DATA
ORL-MAN LDLO:429 MG/KG JTCTDW 31,345,1993
ORL-WMN LDLO:200 MG/KG LANCAO 2,162,1917
ORL-INF LDLO:934 MG/KG JAMAAP 90,382,1928
SKN-INF LDLO:1200 MG/KG JAMAAP 129,332,1945
SKN-CHD LDLO:4 GM/KG/4D MMWOAU 52,763,1905
SKN-MAN LDLO:2430 MG/KG JAMAAP 128,266,1945
SKN-CHD LDLO:1500 MG/KG QJPPAL 6,714,1933
SCU-INF LDLO:1100 MG/KG MDSR** #2,1950
UNR-MAN LDLO:147 MG/KG 85DCAI 2,73,1970
ORL-RAT LD50:2660 MG/KG JAMAAP 128,266,1945
SCU-RAT LD50:1400 MG/KG 14KTAK -,693,1964
IVN-RAT LD50:1330 MG/KG MDSR** #2,1950
ORL-MUS LD50:3450 MG/KG JAMAAP 128,266,1945
SCU-MUS LD50:1740 MG/KG JAMAAP 128,266,1945
IVN-MUS LD50:1240 MG/KG JPETAB 134,117,1961
SCU-GPG LD50:1200 MG/KG MDSR** #2,1950
TARGET ORGAN DATA
BRAIN AND COVERINGS (MENINGEAL CHANGES)
PERIPHERAL NERVE AND SENSATION (FLACCID PARALYSIS WITHOUT ANESTHESIA)
SENSE ORGANS AND SPECIAL SENSES (CONJUNCTIVA IRRITATION)
BEHAVIORAL (WAKEFULNESS)
BEHAVIORAL (SOMNOLENCE)
BEHAVIORAL (TREMOR)
BEHAVIORAL (CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD)
BEHAVIORAL (ANOREXIA, HUMAN)
BEHAVIORAL (FLUID INTAKE)
BEHAVIORAL (ATAXIA)
CARDIAC (OTHER CHANGES)
LUNGS, THORAX OR RESPIRATION (CYANOSIS)
LUNGS, THORAX OR RESPIRATION (RESPIRATORY DEPRESSION)
GASTROINTESTINAL (HYPERMOTILITY, DIARRHEA)
GASTROINTESTINAL (NAUSEA OR VOMITING)
GASTROINTESTINAL (OTHER CHANGES)
KIDNEY, URETER, BLADDER (CHANGES IN TUBULES)
SKIN AND APPENDAGES (AFTER SYSTEMIC EXPOSURE: DERMATITIS, OTHER)
PATERNAL EFFECTS (SPERMATOGENESIS)
PATERNAL EFFECTS (TESTES, EPIDIDYMIS, SPERM DUCT)
MATERNAL EFFECTS (UTERUS, CERVIX, VAGINA)
MATERNAL EFFECTS (OTHER EFFECTS ON FEMALE)
EFFECTS ON EMBRYO OR FETUS (FETOTOXICITY)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (MUSCULOSKELETAL SYSTEM)
NUTRITIONAL AND GROSS METABOLIC (BODY TEMPERATURE INCREASE)
NUTRITIONAL AND GROSS METABOLIC (BODY TEMPERATURE DECREASE)
ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
(RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
CONTACT A LICENSED PROFESSIONAL WASTE DISPOSAL SERVICE TO DISPOSE OF
THIS MATERIAL.
OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
EUROPEAN INFORMATION
HARMFUL
R 63
POSSIBLE RISK OF HARM TO THE UNBORN CHILD.
R 62
POSSIBLE RISK OF IMPAIRED FERTILITY.
R 36/37/38
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
S 45
IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
S 26
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE.
S 36/37/39
WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE
PROTECTION.
S 22
DO NOT BREATHE DUST.
REVIEWS, STANDARDS, AND REGULATIONS
OEL=MAK
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC 54,7740,1989
OEL-RUSSIA: STEL 10 MG/M3, JAN1993
NOES 1983: HZD X7080; NIS 187; TNF 27071; NOS 128; TNE 489668; TFE
211838
NOES 1983: HZD X8324; NIS 3; TNF 84; NOS 4; TNE 2919; TFE 1712
EPA TSCA SECTION 8(B) CHEMICAL INVENTORY
EPA TSCA SECTION 8(D) UNPUBLISHED HEALTH/SAFETY STUDIES
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP CARCINOGENESIS STUDIES (FEED);NO EVIDENCE:MOUSE
NTPTR* NTP-TR-324,1987
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
COPYRIGHT 2001 SIGMA-ALDRICH CO.
LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY
|
|