HEXANES
MSDS Number: H2379 --- Effective Date: 04/15/99
1. Product Identification
Synonyms: Normal Hexane; Hexyl Hydride
CAS No.: 110-54-3 (n-hexane)
Molecular Weight: 86.18
Chemical Formula: CH3(CH2)4CH3 n-hexane
Product Codes: 9277, 9306, 9309, N169
2. Composition/Information on Ingredients
Ingredient CAS No Percent Hazardous
--------------------------------------- ------------ ------- ---------
Hexane 110-54-3 > 95% Yes
Methylcyclopentane 96-37-7 1 - 2% Yes
2-Methylpentane 107-83-5 1 - 2% No
3-Methylpentane 96-14-0 1 - 2% No
Pentane 109-66-0 0 - 2% No
3. Hazards Identification
Emergency Overview
--------------------------
DANGER! EXTREMELY FLAMMABLE LIQUID AND VAPOR. VAPOR MAY CAUSE FLASH FIRE.
HARMFUL OR FATAL IF SWALLOWED. HARMFUL IF INHALED. CAUSES IRRITATION TO SKIN,
EYES AND RESPIRATORY TRACT. AFFECTS THE CENTRAL AND PERIPHERAL NERVOUS
SYSTEMS.
J.T. Baker SAF-T-DATA(tm) Ratings (Provided here for your
convenience)
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Health Rating: 3 - Severe (Life)
Flammability Rating: 4 - Extreme (Flammable)
Reactivity Rating: 2 - Moderate
Contact Rating: 2 - Moderate
Lab Protective Equip: GOGGLES & SHIELD; LAB COAT & APRON; VENT HOOD;
PROPER GLOVES; CLASS B EXTINGUISHER
Storage Color Code: Red (Flammable)
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Potential Health Effects
----------------------------------
The health hazards addressed are for the major component: n-hexane.
Inhalation:
Inhalation of vapors irritates the respiratory tract. Overexposure may cause
lightheadedness, nausea, headache, and blurred vision. Greater exposure may
cause muscle weakness, numbness of the extremities, unconsciousness and death.
Ingestion:
May produce abdominal pain, nausea. Aspiration into lungs can produce severe
lung damage and is a medical emergency. Other symptoms expected to parallel
inhalation.
Skin Contact:
May cause redness, irritation, with dryness, cracking.
Eye Contact:
Vapors may cause irritation. Splashes may cause redness and pain.
Chronic Exposure:
Repeated or prolonged skin contact may defat the skin and produce irritation
and dermatitis. Chronic inhalation may cause peripheral nerve disorders and
central nervous system effects.
Aggravation of Pre-existing Conditions:
Persons with pre-existing skin disorders or eye problems or impaired
respiratory function may be more susceptible to the effects of the substance.
May affect the developing fetus.
4. First Aid Measures
Inhalation:
Remove to fresh air. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. Call a physician.
Ingestion:
Aspiration hazard. If swallowed, DO NOT INDUCE VOMITING. Give large quantities
of water. Never give anything by mouth to an unconscious person. Get medical
attention immediately.
Skin Contact:
Remove any contaminated clothing. Wipe off excess from skin. Wash skin with
soap and water for at least 15 minutes. Get medical attention if irritation
develops or persists.
Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes, lifting
lower and upper eyelids occasionally. Get medical attention immediately.
Note to Physician:
BEI=2,5-hexadione in urine, sample at end of shift at workweeks end, 5 mg/g
creatine. Also, measure n-hexane in expired air. Analgesics may be necessary
for pain management, there is no specific antidote. Monitor arterial blood
gases in cases of severe aspiration.
5. Fire Fighting Measures
Fire:
Flash point: -21C (-6F) CC
Autoignition temperature: 224C (435F)
Flammable limits in air % by volume:
lel: 1.1; uel: 7.5
Extremely Flammable Liquid and Vapor! Vapor may cause flash fire. Dangerous
fire hazard when exposed to heat or flame.
Explosion:
Above flash point, vapor-air mixtures are explosive within flammable limits
noted above. Contact with oxidizing materials may cause extremely violent
combustion.Explodes when mixed @ 28C with dinitrogen tetraoxide. Sensitive to
static discharge.
Fire Extinguishing Media:
Dry chemical, foam or carbon dioxide. Water may be ineffective.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved
self-contained breathing apparatus with full facepiece operated in the
pressure demand or other positive pressure mode. Water spray may be used to
keep fire exposed containers cool. Vapors can flow along surfaces to distant
ignition source and flash back. Vapor explosion hazard exists indoors,
outdoors, or in sewers.
6. Accidental Release Measures
Ventilate area of leak or spill. Remove all sources of ignition. Wear
appropriate personal protective equipment as specified in Section 8. Isolate
hazard area. Keep unnecessary and unprotected personnel from entering. Contain
and recover liquid when possible. Use non-sparking tools and equipment.
Collect liquid in an appropriate container or absorb with an inert material
(e. g., vermiculite, dry sand, earth), and place in a chemical waste
container. Do not use combustible materials, such as saw dust. Do not flush to
sewer! If a leak or spill has not ignited, use water spray to disperse the
vapors, to protect personnel attempting to stop leak, and to flush spills away
from exposures. US Regulations (CERCLA) require reporting spills and releases
to soil, water and air in excess of reportable quantities. The toll free
number for the US Coast Guard National Response Center is (800) 424-8802.
J. T. Baker SOLUSORB(R) solvent adsorbent is recommended for spills of this
product.
7. Handling and Storage
Protect against physical damage. Store in a cool, dry well-ventilated
location, away from direct sunlight and any area where the fire hazard may be
acute. Store in tightly closed containers (preferably under nitrogen
atmosphere). Outside or detached storage is preferred. Inside storage should
be in a standard flammable liquids storage room or cabinet. Separate from
oxidizing materials. Containers should be bonded and grounded for transfers to
avoid static sparks. Storage and use areas should be No Smoking areas. Use
non-sparking type tools and equipment. Containers of this material may be
hazardous when empty since they retain product residues (vapors, liquid);
observe all warnings and precautions listed for the product.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits:
N-Hexane [110-54-3]:
-OSHA Permissible Exposure Limit (PEL): 500 ppm (TWA)
-ACGIH Threshold Limit Value (TLV): 50 ppm (TWA), Skin
other isomers of hexane
-ACGIH Threshold Limit Value (TLV): 500 ppm (TWA),1000ppm (STEL)
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee
exposures below the Airborne Exposure Limits. Local exhaust ventilation is
generally preferred because it can control the emissions of the contaminant at
its source, preventing dispersion of it into the general work area. Please
refer to the ACGIH document, Industrial Ventilation, A Manual of
Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):
If the exposure limit is exceeded, wear a supplied air, full-facepiece
respirator, airlined hood, or full-facepiece self-contained breathing
apparatus. This substance has poor warning properties.
Skin Protection:
Wear impervious protective clothing, including boots, gloves, lab coat, apron
or coveralls, as appropriate, to prevent skin contact.
Eye Protection:
Use chemical safety goggles and/or a full face shield where splashing is
possible. Maintain eye wash fountain and quick-drench facilities in work area.
9. Physical and Chemical Properties
The following properties are for n-hexane, the major component.
Appearance:
Clear, colorless liquid.
Odor:
Gasoline-like odor.
Solubility:
Insoluble in water.
Specific Gravity:
0.66
pH:
No information found.
% Volatiles by volume @ 21C (70F):
100
Boiling Point:
ca. 68C (ca. 154F)
Melting Point:
ca. -95C (ca. -139F)
Vapor Density (Air=1):
3.0
Vapor Pressure (mm Hg):
150 @ 25C (77F)
Evaporation Rate (BuAc=1):
9
10. Stability and Reactivity
Stability:
Stable under ordinary conditions of use and storage. Heat will contribute to
instability.
Hazardous Decomposition Products:
May produce acrid smoke and irritating fumes when heated to decomposition.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Strong oxidizers.
Conditions to Avoid:
Heat, flames, ignition sources and incompatibles.
11. Toxicological Information
N-Hexane: Oral rat LD50: 28710 mg/kg. Irritation eye rabbit: 10 mg mild.
Investigated as a tumorigen, mutagen and reproductive effector.
--------\Cancer Lists\------------------------------------------------------
---NTP Carcinogen---
Ingredient Known Anticipated IARC Category
------------------------------------ ----- ----------- -------------
Hexane (110-54-3) No No None
Methylcyclopentane (96-37-7) No No None
2-Methylpentane (107-83-5) No No None
3-Methylpentane (96-14-0) No No None
Pentane (109-66-0) No No None
12. Ecological Information
Environmental Fate:
When released into the soil, this material may biodegrade to a moderate
extent. When released into the soil, this material is not expected to leach
into groundwater. When released into the soil, this material is expected to
quickly evaporate. When released into water, this material may biodegrade to a
moderate extent. When released to water, this material is expected to quickly
evaporate. When released into the water, this material is expected to have a
half-life between 1 and 10 days. This material has an estimated
bioconcentration factor (BCF) of less than 100. This material has a log
octanol-water partition coefficient of greater than 3.0. This material is not
expected to significantly bioaccumulate. When released into the air, this
material is expected to be readily degraded by reaction with photochemically
produced hydroxyl radicals. When released into the air, this material is
expected to have a half-life between 1 and 10 days.
Environmental Toxicity:
No information found.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be handled as
hazardous waste and sent to a RCRA approved incinerator or disposed in a RCRA
approved waste facility. Processing, use or contamination of this product may
change the waste management options. State and local disposal regulations may
differ from federal disposal regulations. Dispose of container and unused
contents in accordance with federal, state and local requirements.
14. Transport Information
Domestic (Land, D.O.T.)
-----------------------
Proper Shipping Name: HEXANES
Hazard Class: 3
UN/NA: UN1208
Packing Group: II
Information reported for product/size: 215L
International (Water, I.M.O.)
-----------------------------
Proper Shipping Name: HEXANES
Hazard Class: 3.1
UN/NA: UN1208
Packing Group: II
Information reported for product/size: 215L
15. Regulatory Information
--------\Chemical Inventory Status - Part 1\---------------------------------
Ingredient TSCA EC Japan Australia
----------------------------------------------- ---- --- ----- ---------
Hexane (110-54-3) Yes Yes Yes Yes
Methylcyclopentane (96-37-7) Yes Yes No Yes
2-Methylpentane (107-83-5) Yes Yes Yes Yes
3-Methylpentane (96-14-0) Yes Yes Yes Yes
Pentane (109-66-0) Yes Yes Yes Yes
--------\Chemical Inventory Status - Part 2\---------------------------------
--Canada--
Ingredient Korea DSL NDSL Phil.
----------------------------------------------- ----- --- ---- -----
Hexane (110-54-3) Yes Yes No Yes
Methylcyclopentane (96-37-7) Yes Yes No Yes
2-Methylpentane (107-83-5) Yes Yes No Yes
3-Methylpentane (96-14-0) Yes Yes No Yes
Pentane (109-66-0) Yes Yes No Yes
--------\Federal, State & International Regulations - Part 1\----------------
-SARA 302- ------SARA 313------
Ingredient RQ TPQ List Chemical Catg.
----------------------------------------- --- ----- ---- --------------
Hexane (110-54-3) No No Yes No
Methylcyclopentane (96-37-7) No No No No
2-Methylpentane (107-83-5) No No No No
3-Methylpentane (96-14-0) No No No No
Pentane (109-66-0) No No No No
--------\Federal, State & International Regulations - Part 2\----------------
-RCRA- -TSCA-
Ingredient CERCLA 261.33 8(d)
----------------------------------------- ------ ------ ------
Hexane (110-54-3) 5000 No No
Methylcyclopentane (96-37-7) No No No
2-Methylpentane (107-83-5) No No No
3-Methylpentane (96-14-0) No No No
Pentane (109-66-0) No No Yes
Chemical Weapons Convention: No TSCA 12(b): No CDTA: No
SARA 311/312: Acute: Yes Chronic: Yes Fire: Yes Pressure: No
Reactivity: No (Mixture / Liquid)
Australian Hazchem Code: 3[Y]E
Poison Schedule: No information found.
WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled
Products Regulations (CPR) and the MSDS contains all of the information
required by the CPR.
16. Other Information
NFPA Ratings: Health: 1 Flammability: 3 Reactivity: 0
Label Hazard Warning:
DANGER! EXTREMELY FLAMMABLE LIQUID AND VAPOR. VAPOR MAY CAUSE FLASH FIRE.
HARMFUL OR FATAL IF SWALLOWED. HARMFUL IF INHALED. CAUSES IRRITATION TO SKIN,
EYES AND RESPIRATORY TRACT. AFFECTS THE CENTRAL AND PERIPHERAL NERVOUS
SYSTEMS.
Label Precautions:
Keep away from heat, sparks and flame.
Keep container closed.
Use only with adequate ventilation.
Wash thoroughly after handling.
Avoid breathing vapor or mist.
Avoid contact with eyes, skin and clothing.
Label First Aid:
Aspiration hazard. If swallowed, vomiting may occur spontaneously, but DO NOT
INDUCE. If vomiting occurs, keep head below hips to prevent aspiration into
lungs. Never give anything by mouth to an unconscious person. Call a physician
immediately. If inhaled, remove to fresh air. If not breathing, give
artificial respiration. If breathing is difficult, give oxygen. In case of
contact, immediately flush eyes or skin with plenty of water for at least 15
minutes. In all cases call a physician.
Product Use:
Laboratory Reagent.
Revision Information:
MSDS Section(s) changed since last revision of document include: 8. Updated
the ACGIH part of the Airborne section of TAB 8.
Disclaimer:
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Mallinckrodt Baker, Inc. provides the information contained herein in good
faith but makes no representation as to its comprehensiveness or accuracy.
This document is intended only as a guide to the appropriate precautionary
handling of the material by a properly trained person using this product.
Individuals receiving the information must exercise their independent judgment
in determining its appropriateness for a particular purpose. MALLINCKRODT
BAKER, INC. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED,
INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A
PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE
PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, MALLINCKRODT BAKER, INC.
WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE UPON
THIS INFORMATION.
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Prepared by: Strategic Services Division
Phone Number: (314) 539-1600 (U.S.A.)