ETHYLENE GLYCOL
MSDS Number: E5125 --- Effective Date: 02/25/99
1. Product Identification
Synonyms: 1,2-Ethanediol; glycol; 1,2-Dihydroxyethane; Ethylene
Alcohol; Ethulene Dihydrate
CAS No.: 107-21-1
Molecular Weight: 62.07
Chemical Formula: CH2OHCH2OH
Product Codes:
J.T. Baker: 5387, 5845, 9140, 9298, 9300, 9346, 9349, 9356, L715
Mallinckrodt: 5001, 5037
2. Composition/Information on Ingredients
Ingredient CAS No Percent Hazardous
--------------------------------------- ------------ ------- ---------
Ethylene Glycol 107-21-1 99 - 100% Yes
3. Hazards Identification
Emergency Overview
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WARNING! HARMFUL OR FATAL IF SWALLOWED. HARMFUL IF INHALED OR ABSORBED
THROUGH SKIN. MAY CAUSE ALLERGIC SKIN REACTION. MAY CAUSE IRRITATION TO SKIN,
EYES, AND RESPIRATORY TRACT. AFFECTS CENTRAL NERVOUS SYSTEM.
J.T. Baker SAF-T-DATA(tm) Ratings (Provided here for your
convenience)
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Health Rating: 2 - Moderate
Flammability Rating: 1 - Slight
Reactivity Rating: 1 - Slight
Contact Rating: 2 - Moderate
Lab Protective Equip: GOGGLES; LAB COAT; VENT HOOD; PROPER GLOVES
Storage Color Code: Orange (General Storage)
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Potential Health Effects
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Inhalation:
Vapor inhalation is generally not a problem unless heated or misted. Exposure
to vapors over an extended time period has caused throat irritation and
headache. May cause nausea, vomiting, dizziness and drowsiness. Pulmonary
edema and central nervous system depression may also develop. When heated or
misted, has produced rapid, involuntary eye movement and coma.
Ingestion:
Initial symptoms in massive dosage parallel alcohol intoxication, progressing
to CNS depression, vomiting, headache, rapid respiratory and heart rate,
lowered blood pressure, stupor, collapse, and unconsciousness with
convulsions. Death from respiratory arrest or cardiovascular collapse may
follow. Lethal dose in humans: 100 ml (3-4 ounces).
Skin Contact:
Minor skin irritation and penetration may occur.
Eye Contact:
Splashes may cause irritation, pain, eye damage.
Chronic Exposure:
Repeated small exposures by any route can cause severe kidney problems. Brain
damage may also occur. Skin allergy can develop. May damage the developing
fetus.
Aggravation of Pre-existing Conditions:
Persons with pre-existing skin disorders, eye problems, or impaired liver,
kidney, or respiratory function may be more susceptible to the effects of this
substance.
4. First Aid Measures
Inhalation:
Remove to fresh air. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. Call a physician.
Ingestion:
Induce vomiting immediately as directed by medical personnel. Never give
anything by mouth to an unconscious person. Get medical attention.
Skin Contact:
Remove any contaminated clothing. Wash skin with soap and water for at least
15 minutes. Get medical attention if irritation develops or persists.
Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes, lifting
lower and upper eyelids occasionally. Get medical attention immediately.
Note to Physician:
Give sodium bicarbonate intravenously to treat acidosis. Urinalysis may show
low specific gravity, proteinuria, pyuria, cylindruria, hematuria, calcium
oxide, and hippuric acid crystals. Ethanol can be used in antidotal treatment
but monitor blood glucose when administering ethanol because it can cause
hypoglycemia. Consider infusion of a diuretic such as mannitol to help prevent
or control brain edema and hemodialysis to remove ethylene glycol from
circulation.
5. Fire Fighting Measures
Fire:
Flash point: 111C (232F) CC
Autoignition temperature: 398C (748F)
Flammable limits in air % by volume:
lel: 3.2; uel: 15.3
Slight to moderate fire hazard when exposed to heat or flame.
Explosion:
Above flash point, vapor-air mixtures are explosive within flammable limits
noted above. Containers may explode when involved in a fire.
Fire Extinguishing Media:
Dry chemical, foam or carbon dioxide. Water or foam may cause frothing. Water
spray may be used to extinguish surrounding fire and cool exposed containers.
Water spray will also reduce fume and irritant gases.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved
self-contained breathing apparatus with full facepiece operated in the
pressure demand or other positive pressure mode. Toxic gases and vapors may be
released if involved in a fire.
6. Accidental Release Measures
Ventilate area of leak or spill. Remove all sources of ignition. Wear
appropriate personal protective equipment as specified in Section 8. Isolate
hazard area. Keep unnecessary and unprotected personnel from entering. Contain
and recover liquid when possible. Use non-sparking tools and equipment.
Collect liquid in an appropriate container or absorb with an inert material
(e. g., vermiculite, dry sand, earth), and place in a chemical waste
container. Do not use combustible materials, such as saw dust. Do not flush to
sewer! US Regulations (CERCLA) require reporting spills and releases to soil,
water and air in excess of reportable quantities. The toll free number for the
US Coast Guard National Response Center is (800) 424-8802.
7. Handling and Storage
Keep in a tightly closed container, stored in a cool, dry, ventilated area.
Protect against physical damage. Separate from acids and oxidizing materials.
Containers of this material may be hazardous when empty since they retain
product residues (vapors, liquid); observe all warnings and precautions listed
for the product.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits:
-OSHA Permissible Exposure Limit (PEL):
50 ppm Ceiling
-ACGIH Threshold Limit Value (TLV):
50 ppm Ceiling (vapor)
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee
exposures below the Airborne Exposure Limits. Local exhaust ventilation is
generally preferred because it can control the emissions of the contaminant at
its source, preventing dispersion of it into the general work area. Please
refer to the ACGIH document, Industrial Ventilation, A Manual of
Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):
If the exposure limit is exceeded, a half-face respirator with an organic
vapor cartridge and particulate filter (NIOSH type P95 or R95 filter) may be
worn for up to ten times the exposure limit or the maximum use concentration
specified by the appropriate regulatory agency or respirator supplier,
whichever is lowest. A full-face piece respirator with an organic vapor
cartridge and particulate filter (NIOSH P100 or R100 filter) may be worn up to
50 times the exposure limit, or the maximum use concentration specified by the
appropriate regulatory agency or respirator supplier, whichever is lowest.
Please note that N series filters are not recommended for this material. For
emergencies or instances where the exposure levels are not known, use a
full-face piece positive-pressure, air-supplied respirator. WARNING:
Air-purifying respirators do not protect workers in oxygen-deficient
atmospheres.
Skin Protection:
Wear protective gloves and clean body-covering clothing.
Eye Protection:
Use chemical safety goggles. Maintain eye wash fountain and quick-drench
facilities in work area.
9. Physical and Chemical Properties
Appearance:
Clear oily liquid.
Odor:
Odorless.
Solubility:
Miscible in water.
Specific Gravity:
1.1 @20C/4C
pH:
No information found.
% Volatiles by volume @ 21C (70F):
100
Boiling Point:
197.6C (388F)
Melting Point:
-13C (9F)
Vapor Density (Air=1):
2.14
Vapor Pressure (mm Hg):
0.06 @ 20C (68F)
Evaporation Rate (BuAc=1):
No information found.
10. Stability and Reactivity
Stability:
Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products:
Carbon dioxide and carbon monoxide may form when heated to decomposition. May
produce acrid smoke and irritating fumes when heated to decomposition.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Strong oxidizing agents. Reacts violently with chlorosulfonic acid, oleum,
sulfuric acid, perchloric acid. Causes ignition at room temperature with
chromium trioxide, potassium permanganate and sodium peroxide; causes ignition
at 212F(100C) with ammonium dichromate, silver chlorate, sodium chloride and
uranyl nitrate.
Conditions to Avoid:
Heat, flames, ignition sources, water (absorbs readily) and incompatibles.
11. Toxicological Information
Toxicological Data:
Oral rat LD50: 4700 mg/kg; skin rabbit LD50: 9530 mg/kg.
Irritation - skin rabbit: 555mg(open), mild; eye rabbit: 500mg/24H, mild.
Investigated as a tumorigen, mutagen, reproductive effector.
Reproductive Toxicity:
Has shown teratogenic effects in laboratory animals.
--------\Cancer Lists\------------------------------------------------------
---NTP Carcinogen---
Ingredient Known Anticipated IARC Category
------------------------------------ ----- ----------- -------------
Ethylene Glycol (107-21-1) No No None
12. Ecological Information
Environmental Fate:
When released into the soil, this material is expected to readily biodegrade.
When released into the soil, this material is expected to leach into
groundwater. When released into the soil, this material is not expected to
evaporate significantly. When released into water, this material is expected
to readily biodegrade. When released into the water, this material is expected
to have a half-life between 1 and 10 days. This material is not expected to
significantly bioaccumulate. This material has a log octanol-water partition
coefficient of less than 3.0. When released into water, this material is not
expected to evaporate significantly. When released into the air, this material
is expected to be readily degraded by reaction with photochemically produced
hydroxyl radicals. When released into the air, this material is expected to
have a half-life between 1 and 10 days.
Environmental Toxicity:
The LC50/96-hour values for fish are over 100 mg/l.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be managed in an
appropriate and approved waste disposal facility. Processing, use or
contamination of this product may change the waste management options. State
and local disposal regulations may differ from federal disposal regulations.
Dispose of container and unused contents in accordance with federal, state and
local requirements.
14. Transport Information
Not regulated.
15. Regulatory Information
--------\Chemical Inventory Status - Part 1\---------------------------------
Ingredient TSCA EC Japan Australia
----------------------------------------------- ---- --- ----- ---------
Ethylene Glycol (107-21-1) Yes Yes Yes Yes
--------\Chemical Inventory Status - Part 2\---------------------------------
--Canada--
Ingredient Korea DSL NDSL Phil.
----------------------------------------------- ----- --- ---- -----
Ethylene Glycol (107-21-1) Yes Yes No Yes
--------\Federal, State & International Regulations - Part 1\----------------
-SARA 302- ------SARA 313------
Ingredient RQ TPQ List Chemical Catg.
----------------------------------------- --- ----- ---- --------------
Ethylene Glycol (107-21-1) No No Yes No
--------\Federal, State & International Regulations - Part 2\----------------
-RCRA- -TSCA-
Ingredient CERCLA 261.33 8(d)
----------------------------------------- ------ ------ ------
Ethylene Glycol (107-21-1) 5000 No No
Chemical Weapons Convention: No TSCA 12(b): No CDTA: No
SARA 311/312: Acute: Yes Chronic: Yes Fire: No Pressure: No
Reactivity: No (Pure / Liquid)
Australian Hazchem Code: No information found.
Poison Schedule: No information found.
WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled
Products Regulations (CPR) and the MSDS contains all of the information
required by the CPR.
16. Other Information
NFPA Ratings: Health: 1 Flammability: 1 Reactivity: 0
Label Hazard Warning:
WARNING! HARMFUL OR FATAL IF SWALLOWED. HARMFUL IF INHALED OR ABSORBED THROUGH
SKIN. MAY CAUSE ALLERGIC SKIN REACTION. MAY CAUSE IRRITATION TO SKIN, EYES,
AND RESPIRATORY TRACT. AFFECTS CENTRAL NERVOUS SYSTEM.
Label Precautions:
Do not breathe vapor or mist.
Use only with adequate ventilation.
Keep container closed.
Avoid contact with eyes, skin and clothing.
Wash thoroughly after handling.
Label First Aid:
If inhaled, remove to fresh air. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. In case of contact,
immediately flush skin or eyes with plenty of water for at least 15 minutes.
Call a physician if irritation develops or persists. If swallowed, give water
or milk to drink and induce vomiting. Never give anything by mouth to an
unconscious person. In all cases call a physician.
Product Use:
Laboratory Reagent.
Revision Information:
MSDS Section(s) changed since last revision of document include: 8.
Disclaimer:
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Mallinckrodt Baker, Inc. provides the information contained herein in good
faith but makes no representation as to its comprehensiveness or accuracy.
This document is intended only as a guide to the appropriate precautionary
handling of the material by a properly trained person using this product.
Individuals receiving the information must exercise their independent judgment
in determining its appropriateness for a particular purpose. MALLINCKRODT
BAKER, INC. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED,
INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A
PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE
PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, MALLINCKRODT BAKER, INC.
WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE UPON
THIS INFORMATION.
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Prepared by: Strategic Services Division
Phone Number: (314) 539-1600 (U.S.A.)