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Progress in high-pressure crystallography at ID7B2 furthers the mission of HP-Bio
Recent developments at station ID7B2, jointly operated by MacCHESS and the HP-Bio project of CHEXS, demonstrate the use of high-pressure crystallography to examine the response of macromolecules to changes in pressure.
ACA honors staff scientist Richard Gillilan
Richard Gillilan, a MacCHESS/CHEXS staff scientist, has been named a member of the 2021 class of Fellows of the American Crystallographic Association (ACA), in recognition of his many career achievements.
Protein unfolded states populated at high and ambient pressure are similarly compact
This is perhaps the first reported study of the temperature dependence of the dimensions of the high pressure unfolded state of a protein. These measurements strongly support the notion that pressure unfolded proteins do not differ significantly from proteins which are unfolded at atmospheric pressure.
A virus recognizes the starting point on the DNA to be packaged inside its protein shell
A bacteriophage – a virus that attacks bacteria – assembles into an infectious species using a powerful nanomachine to stuff its DNA into a protein shell. In several types of phage, this genome packaging motor is composed of several copies of large and small terminase subunits (TerL and TerS, respectively) that attach to a portal into the protein procapsid.
2021 CHESS Users' Meeting - Save the Date!
The 2021 CHESS Users' Meeting will take place on June 8/9, 2021 as a virtual meeting with plenary sessions, poster sessions and workshops held online and accessible for participants remotely.
Women and Girls in Science at CHESS
At CHESS, we are proud to have women in leadership roles that steer the scientific mission of the lab, scientists, postdocs and students who explore the future of materials, and research support specialists and technical experts who ensure that the everyday science at CHESS remains cutting edge.
February 11th is the International Day of Women and Girls in Science.
BioSAXS facility at CHEXS develops stringent anoxic sample environment
From the gut microbiome to the depths of the ocean, life has evolved to thrive in the absence of oxygen. In fact, it is not hyperbole to say that life as we know it would not exist without the oxygen sensitive metalloenzymes that we all rely on.
High-pressure small-angle X-ray scattering cell for biological solutions and soft materials
Pressure is a fundamental thermodynamic parameter controlling the behavior of biological macromolecules. In many cases pressure alters molecular shape and therefore also the biological function. Small angle X-ray scattering (SAXS) is a widely used method to determine the shape and size of macromolecules, but typical sample cells for SAXS experiments are unsuitable for use at high pressures.