Pressure is a fundamental thermodynamic parameter that affects the free energy of a system. For macromolecules in solution, this often results in changes in molecular structure.

MX experiments under pressure in diamond anvil cell (DAC)

How does the diffraction from a single crystal change with pressure?

High pressure is a tool that can be used to alter the equilibrium population of molecular conformations and associations, both in crystals and in solutions.

In addition to the workhorse techniques of macromolecular crystallography (MX) and BioSAXS, MacCHESS welcomes experiments that use X-rays in other ways, as well as novel applications of MX an