Experiments using high pressure are not routine; they always involve MacCHESS staff. For crystallographic experiments non-frozen crystals are required.

High Pressure Cryocooling (HPC) is an alternative to standard cryocooling which can reduce the damage due to the cooling process and can sometimes even improve the initial quality of a crystal.

There are several applications of HPC, of which the most important are: (1) At pressures of 200-400 MPa, applied with helium, HPC can improve the quality of diffraction from a crystal, by reducing

Pressure is a fundamental thermodynamic parameter that affects the free energy of a system. For macromolecules in solution, this often results in changes in molecular structure.

MX experiments under pressure in diamond anvil cell (DAC)

How does the diffraction from a single crystal change with pressure?