It replaces the original (30 year old) CHESS 4-circle, and provides many new capabilities. This system weighs 4600 pounds together with its support table engineered by Alan Pauling, based on an APS Sector 7 design. The table was built for CHESS in New York State, by Keller Engineering in Buffalo.
RNR plays a critical role in regulating the total rate of DNA synthesis, which is necessary to maintain the constant DNA to cell mass ratio during cell division and DNA repair. The reaction is strictly conserved in all living organisms and proceeds via a free radical mechanism of action. Class Ia RNR (e. g. Escherichia coli RNR) enzymes are constructed from large RNR α2 and small RNR β2 subunits which associate to form an active heterodimeric tetramer: an α2β2 complex.
The "PiXirad-1" module mounts easily on the 4-circle diffractometer at the A2 endstation, and is fully integrated into SPEC control. First-ever synchrotron tests and user experiments using the PiXirad were performed at CHESS during 2013. The defining advantage of this unit is the use of a CdTe crystal sensor instead of Si, which gives the PiXirad very high detection efficiency (> 90%) for photons with energies greater than 50 keV.
The G1 beamline control area has been renovated and reorganized to make more efficient use of space and to accommodate larger groups. The G-line chem room, which has a dedicated BioSAXS sample preparation area, now has high-quality ultrapure water on tap and all the equipment you need to prepare a wide variety of buffers.
In addition to the ability to generate 3D reconstructions of the sample in question via optical sectioning, confocal microscopy can also be used to measure reaction kinetics in the fluorescence mode.
The paper must be based in part on data collected at the Cornell High Energy Synchrotron Source, and the first author on the paper must have been a graduate or undergraduate student when the paper was submitted. (In certain circumstances, two submissions may be selected as winners, in which case the award will be shared.)
NSLS-II will significantly expand the frontiers of science enabled by coherent x-ray beams. An unavoidable consequence, however, is that many current NSLS users need to find homes for their research programs during the “dark period.” The new undulators (to be installed this summer), a new suite of state-of-the-art area detectors, and our East Coast location make CHESS a very attractive choice for many current NSLS users.
Over the next three year period Smilgies will supervise projects for CBE masters of engineering students as well as work closely with faculty and students, to counsel them in the use of x-ray scattering methods for their research. In addition he will work with CBE faculty on methodology, on how to tackle frontier chemical engineering problems with x-ray scattering methods.
In preparation for the need to collect, analyze, and archive up to 100 terabytes of data per year, CHESS has launched an initiative to upgrade its computing infrastructure, drawing on the host laboratory's decades-long experience with operating high-energy physics experiments. Among the planned improvements are new high-throughput redundant storage devices for data collection at each x-ray beamline, an offsite magnetic tape archive for long-term storage, cutting-edge processors for immediate data analysis, and a high-speed 10-gigabit network to connect all these elements together.