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CHESS is a high-intensity X-ray source supported by the National Science Foundation which provides our users state-of-the-art synchrotron radiation facilities for research in Physics, Chemistry, Biology, and Environmental and Materials Sciences. A special NIH Research Resource, called MacCHESS, supports special facilities for macromolecular crystallography and BioSAXS. CHESS-U is the current upgrade that will extend CHESS's capacity for cutting edge research.