2018 X-RAY RUNS: February 7 - April 3 & April 11 - June 4

NOTICE: CHESS will be down June 4, 2018 until February 2019 due to the planned CHESS-U upgrade. Please plan for this in your research.

MacCHESS (Macromolecular X-ray science at the Cornell High Energy Synchrotron Source) provides a facility where scientists can use both established and emerging technologies to pursue the goals of the biomedical research community. Work performed at MacCHESS, using tools including e.g. crystallography and small-angle X-ray scattering, yields important insights into fundamental biological processes, such as signaling across membranes, regulation of ion channels in neuronal function, enzyme catalysis, and gene expression.

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In addition to the workhorse techniques of macromolecular crystallography (MX) and BioSAXS, MacCHESS welcomes experiments that use X-rays in other ways, as well as novel applications of MX an

Macromolecular crystallography (MX) is a method for determining the structures of proteins, viruses and nucleic acids (RNA and DNA) from X-ray diffraction of crystals of those molecules.

Biological Small Angle X-ray Solution Scattering (BioSAXS) is a popular method that yields valuable structural information from solutions of biomolecules.

High pressure is a tool that can be used to alter the equilibrium population of molecular conformations and associations, both in crystals and in solutions.

One major bottleneck in the protein crystallography experiment is collection of a complete dataset prior to the onset of radiation damage.

MacCHESS supports several beamlines, on either a full-time or part-time basis.

Publishing work using data collected at MacCHESS