MacCHESS User Publications

Journal

Complete lists of CHESS user publications

2024

  1. Abdelhady A.W., Mittan‑Moreau D.W., Crane P.L., McLeod M.J., Soon Hon Cheong S.H., Thorne R.E. "Ice formation and its elimination in cryopreservation of oocytes." Sci. Rep., 14, 18809, 2024. doi: 10.1038/s41598-024-69528-8 Instrument: ID7B2 (HPBio MX & FlexX)
  2. Adams M.C, Schiltz C.J., Sun J., Hosford C.J., Johnson V.M., Pan H., Borbat P.P., Freed J.H., Thomason L.C., Court C., Court D.L., Chappie J.C. "The crystal structure of bacteriophage λ RexA provides novel insights into the DNA binding properties of Rex-like phage exclusion proteins." Nucleic Acids Research, 52, 8, 4659–4675, 2024. doi: 10.1093/nar/gkae212. Instrument: F1
  3. Aplin C., Zielinski K.A., Pabit S., Ogunribido D., Katt W.P., Pollack L., Cerione R.A., Milano S.K. "Defining the conformational states that enable transglutaminase 2 to promote cancer cell survival versus cell death." bioRxiv. Preprint. 2024. doi: 10.1101/2024.02.04.578794. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  4. Balu K.E., Almohdar D., Ratcliffe J., Tang Q., Parwal T., Çağlayan M. "Structural and biochemical characterization of LIG1 during mutagenic nick sealing of oxidatively damaged ends at the final step of DNA repair." bioRxiv. Preprint. 2024. doi: 10.1101/2024.05.06.592774. Instrument: ID7B2 (HPBio MX & FlexX)
  5. Balu K.E., Gulkis M., Almohdar D., Çağlayan M. "Structures of LIG1 provide a mechanistic basis for understanding a lack of sugar discrimination against a ribonucleotide at the 3'-end of nick DNA." JBC, 300, 5, 107216, 2024, doi: 10.1016/j.jbc.2024.107216 Instrument: ID7B2 (HPBio MX & FlexX)
  6. Balu K.E., Tang Q., Almohdar A., Ratcliffe J., Kalaycioğlu M., Çağlayan M. "Structures of LIG1 uncover a mechanism for a sugar discrimination against a ribonucleotide at the 5'-end of nick DNA during ribonucleotide excision repair." JBC, In press. 2024. doi: 10.1016/j.jbc.2024.107688 Instrument: ID7B2 (HPBio MX & FlexX)
  7. Barnes C.L., Salom D., Namitz K.E. W., Smith W.C., Knutson B.A., Cosgrove M.S., Kiser P.D., Calvert P.D. "Mechanisms of amphibian arrestin 1 self-association and dynamic distribution in retinal photoreceptors." JBC., 300, 12, 107966, 2024. doi: 10.1016/j.jbc.2024.107966. Instrument: ID7B2 (HPBio MX & FlexX)
  8. Debnath J., Keshamasetthy D., Combs J., Leon K., Vullo D., Chatterjee A., McKenna R., Supuran C.T. "A comparative study of diaryl urea molecules with and without sulfonamide group on Carbonic anhydrase IX and XII inhibition and its consequence on breast cancer cells." Bioorganic Chemistry, 145, 107192, 2024. doi: 10.1016/j.bioorg.2024.107192  Instrument: ID7B2 (HPBio MX & FlexX)
  9. Gao T., Kabir S., Wu J. "Structure of Talin Bound to β2 Integrin Unveils the Molecular Mechanism of Species-Specific Integrin Activation." bioRxiv. Preprint. 2024. doi: 10.1101/2024.05.28.596271 Instrument: ID7B2 (HPBio MX & FlexX)
  10. Guerrero L., Ebrahim A., Riley B.T., Kim M., Huang Q., Finke A.D., Keedy D.A. "Pushed to extremes: distinct effects of high temperature vs. pressure on the structure of STEP". Nat. Commun. Biol. 7, 59, 2024. doi: 10.1038/s42003-023-05609-0. Instrument: ID7B2 (HPBio MX & FlexX)
  11. Hossain M.A., Sarin R., Donnelly D.P., Miller B.C., Weiss A., McAlary L., Antonyuk S.V., Salisbury J.P., Amin J., Conway J.B., Watson S.S., Winters J.N., Xu Y., Alam N.,  Brahme R.R., Shahbazian H.,  Sivasankar D., Padmakumar S., SattarovaA., Ponmudiyan A.C., Gawde T., Verrill D.E., Yang W., Kaanapali S., Plant L.D., Auclair J.R., Makowski L., Petsko G.A., Ringe D., Agar N.Y.R., Greenblatt D.J., Ondrechen M.J., Chen Y., Yerbury J.J., Manetsch R., Hasnain S.S., Brown R.H. Jr., Agar J.N. "Evaluating protein cross-linking as a therapeutic strategy to stabilize SOD1 variants in a mouse model of familial ALS." PLOS Biology, 2024. doi: 10.1371/journal.pbio.3002462 Instrument: G1
  12. Kayrouz C.M., Ireland K.A., Ying V., Davis K.M., Mohammad R. Seyedsayamdost M.R. "Ovoselenol, a Selenium-containing Antioxidant Derived from Convergent Evolution." bioRxiv. Preprint. 2024. doi: 10.1101/2024.04.10.588772 Instrument: ID7B2 (HPBio MX & FlexX)
  13. Khojastegi A., Khosropour A., Amirjalayer S., MoslehI., Abbaspourrad A. "Modulating Narrow Bandgap in a Diacetylene Functionalized Woven Covalent Organic Framework as a Visible Light Responsive Photocatalyst." Wiley Online Library, 2024. doi: 10.1002/adfm.202309367 Instrument: ID7B2 (HPBio MX & FlexX)
  14. Li Y., Plummer A., WernerJ.G. "Chemically Nanostructured Organogel Monoliths from Cross-Linked Block Copolymers for Selective Infusion Templating." ACS Nano, 18(29), 19150-19160, 2024, doi: 10.1021/acsnano.4c04394. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  15. Meisburger S.P., Ando N. "Scaling and merging macromolecular diffuse scattering with mdx2". Acta Cryst. D, 80, 5, 299-313, 2024. doi: 10.1107/S2059798324002705. Instrument: F1
  16. Morin C., Verma V.T., Arya T., Casu B., Jolicoeur E., Ruel R., Marinier A.M., Sygusch J., Baron C. "Structure-based design of small molecule inhibitors of the cagT4SS ATPase Cagα of Helicobacter pylori." Biochemistry and Cell Biology, 2024. doi: 10.1139/bcb-2023-0331 Instrument: G1
  17. Peng K., Wallace S.D., Bagde S.R., Shang J., Anmangandla A., Jana S., Fromme J.C., Lin H. "GS-441524-Diphosphate-Ribose Derivatives as Nanomolar Binders and Fluorescence Polarization Tracers for SARS-CoV-2 and Other Viral Macrodomains". ACS Chem. Biol., 2024. doi: 10.1021/acschembio.4c00027. Instrument: ID7B2 (HPBio MX & FlexX)
  18. Petraccione K., Ali M.J.H., Cyr N., Wahba H.M., Stocker T., Akhrymuk M., Akhrymuk I., PannyL., Bracci N., Cafaro R., Sastre D., Silberfarb A., O’Maille P., Omichinski J., Kehn-Hall K. "An LIR motif in the Rift Valley fever virus NSs protein is critical for the interaction with LC3 family members and inhibition of autophagy." doi: 10.1371/journal.ppat.1012093 Instrument: ID7B2 (HPBio MX & FlexX)
  19. Sedinkin S.L., Roche J., Venditti V. "Elucidation of the Mechanisms of Inter-domain Coupling in the Monomeric State of Enzyme I by High-pressure NMR." JMB, 436, 9 , 168553, 2024. doi: 10.1016/j.jmb.2024.168553. Instrument: ID7A1 (HP BioSAXS & BioSAXS) 
  20. Sherik M., Eves R., Guo S., Lloyd C.J., Klose K.E., Davies P.L. "Sugar-binding and split domain combinations in repeats-in-toxin adhesins from Vibrio cholerae and Aeromonas veronii mediate cell-surface recognition and hemolytic activities." mBio. 15:e02291-23, 2024. doi: 10.1128/mbio.02291-23. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  21. Schneps C.M., Dunleavy R., Crane B.R. "Dissecting the Interaction between Cryptochrome and Timeless Reveals Underpinnings of Light-Dependent Recognition." Biochemistry, 63, 4, 2024. doi: 10.1021/acs.biochem.3c00630 Instrument: ID7A1 (HP BioSAXS & BioSAXS) 
  22. Schuelke-Sanchez A., Yennawar N.H., Weinert E.E. "Oxygen-selective regulation of cyclic di-GMP synthesis by a globin coupled sensor with a shortened linking domain modulates Shewanella sp. ANA-3 biofilm." Journal of Inorganic Biochemistry,  252, 112482, 2024. doi: 10.1016/j.jinorgbio.2024.112482 Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  23. Winnikoff J.R., Milshteyn D., Vargas-Urbano S.J., Pedraza-Joya M.A., Armando A.M., Quehenberger O., Sodt A., Gillilan R.E., Dennis E.A., Lyman E., Haddock S.H.D., Budin I. "Homeocurvature adaptation of phospholipids to pressure in deep-sea invertebrates." Science, 384, 6703, 1482-1488, 2024. doi: 10.1126/science.adm7607. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  24. Ye Q., Henrickson A., Demeler B., Serrão V.H.B., Davies P.L. "Human calpain-3 and its structural plasticity: dissociation of a homohexamer into dimers on binding titin" bioRxiv 2024.02.28.582628; doi: 10.1101/2024.02.28.582628 (This article is a preprint and has not been certified by peer review)
  25. Zawistowski R.K., Crane B.R. "Differential responses in the core, active site and peripheral regions of cytochrome c peroxidase to extreme pressure and temperature." bioRxiv 2024. doi: 10.1101/2024.07.24.604936 (This article is a preprint and has not been certified by peer review). Instrument: ID7B2 (HPBio MX & FlexX)

Thesis: 

  1. Barwell Sarah. (2024). Structural and Biochemical Insights into Previously Uncharacterized Activity of Nucleotide-Dependent Phosphoenolpyruvate Carboxykinases. Ph.D., University of Waterloo.

2023

  1. Biswas S, Hecht AL, Noble SA, Huang Q, Gillilan RE, Xu AY. "Understanding the Impacts of Molecular and Macromolecular Crowding Agents on Protein-Polymer Complex Coacervates." Biomacromolecules, 24, 11, 4771-4782, 2023. doi: 10.1021/acs.biomac.3c00545. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  2. Chowdhury A., Manohar N., Guruprasad G., Chen A.T., Lanzaro A.,  Blanco M., Johnston K.P., Truskett T.M. "Characterizing Experimental Monoclonal Antibody Interactions and Clustering Using a Coarse-Grained Simulation Library and a Viscosity Model." J. Phys. Chem., B, 127, 5, 1120–1137, 2023. doi: 10.1021/acs.jpcb.2c07616. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  3. Chowdhury A.A., Manohar N., Witek M.A., Woldeyes M.A., Majumdar R., Qian K.K., Kimball W.D., Xu S., Lanzaro A., Truskett T.M. and Johnston K.P. "Subclass Effects on Self-Association and Viscosity of Monoclonal Antibodies at High Concentrations." Mol. Pharmaceutics., 20, 6, 2991–3008, 2023. doi: 10.1021/acs.molpharmaceut.3c00023. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  4. Combs J., Bozdag M., Cravey L. D., Kota A., McKenna R., Angeli A., Carta F., & Supuran C. T. "New Insights into Conformationally Restricted Carbonic Anhydrase Inhibitors". Molecules, 28, 2, Article 2. 2023. doi: 10.3390/molecules28020890. Instrument: ID7B2 (HPBio MX & FlexX)
  5. Cui G., Botuyan M.V., Drané P., Hu Q., Bragantini B., Thompson J.R., Schuller D.J., Detappe A., Perfetti M.T., James L.I., Frye S.V., Chowdhury D., Mer G. "An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering." Nat. Commun., 14, 1, 6091, 2023. doi: 10.1038/s41467-023-41821-6. Instrument: A1
  6. Eilers G., Gupta K., Allen A., Montermoso S., Murali H., Sharp R., Hwang Y., Bushman F. D., & Van Duyne G. "Structure of a HIV-1 IN-Allosteric inhibitor complex at 2.93 Å resolution: Routes to inhibitor optimization". PLoS Pathogens, 19, 3, 2023. doi: 10.1371/journal.ppat.1011097. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  7. Ford R.R., Gilbert P.H., Gillilan R., Huang Q., Donnelly R., Qian K.K., Allen D.P., Wagner N.J., Liu Y. "Micelle Formation and Phase Separation of Poloxamer 188 and Preservative Molecules in Aqueous Solutions Studied by Small Angle X-ray Scattering". J. Pharm. Sci., 112, 3, 731-739, 2023. doi: 10.1016/j.xphs.2022.09.019. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  8. Ghosh D. "Structures and functions of human placental aromatase and steroid sulfatase, two key enzymes in estrogen biosynthesis." Steroids, 196, 109249, 2023. doi: 10.1016/j.steroids.2023.109249. Instrument: A1, F2
  9. Guerrero L., Ebrahim A., Riley B.T., Kim M., Huang Q., Finke A.D., Keedy D.A. "Pushed to extremes: distinct effects of high temperature vs. pressure on the structure of an atypical phosphatase". bioRxiv preprint, 2023. doi: 10.1101/2023.05.02.538097 Instrument: ID7B2 (HPBio MX & FlexX)
  10. Huang Q, Szebenyi D.M.E. "Crystal structure of a type III Rubisco in complex with its product 3-phosphoglycerate." Proteins. 91, 3, 330-337, 2023. doi.org/10.1002/prot.26431. Instrument: F1
  11. Huang Q., Szebenyi  D.M.E. "The alarmone ppGpp selectively inhibits the isoform A of the human small GTPase Sar1". Proteins, 91, 4, 518-531, 2023. doi: 10.1002/prot.26445. Instrument: A1, F1, ID7A1 (HP BioSAXS & BioSAXS)
  12. Huang X., Suit E., Zhu J., Ge B., Gerdes F., Klinke C., Wang Z. "Diffusion-Mediated Nucleation and Growth of fcc and bcc Nanocrystal Superlattices with Designable Assembly of Freestanding 3D Supercrystals". J Am Chem Soc.,145, 8, 4500-4507, 2023. doi: 10.1021/jacs.2c11120. Instrument: ID7B2 (HPBio MX & FlexX), B2
  13. Illava G., Gillilan R., Ando N. "Development of in-line anoxic small-angle X-ray scattering and structural characterization of an oxygen-sensing transcriptional regulator". J. Biol. Chem., 299, 8, 105039, 2023. doi: 10.1016/j.jbc.2023.105039. Instrument: ID7B2 (HPBio MX & FlexX)
  14. Jakkampudi T., Lin Q., Mitra S., Vijai A., Qin W., Kang A., Chen J., Ryan E., Wang R., Gong Y., Heinrich F., Song J., Di Y-P. (P). and Tristram-Nagle S. "Lung SPLUNC1 Peptide Derivatives in the Lipid Membrane Headgroup Kill Gram-Negative Planktonic and Biofilm Bacteria". Biomacromolecules, 24, 6, 2804–2815, 2023. doi: 10.1021/acs.biomac.3c00218. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  15. Lee E., McLeod M.J., Redzic J.S., Marcolin B., Thorne R.E., Agarwal P., Eisenmesser E.Z. "Identifying structural and dynamic changes during the Biliverdin Reductase B catalytic cycle." Front Mol. Biosci., 2023; 10: 1244587, 2023. doi: 10.3389/fmolb.2023.1244587. Instrument: ID7B2 (HPBio MX & FlexX)
  16. Lisitskaya L., Shin Y., Agapov A., Olina A., Kropocheva E., Ryazansky S., Aravin A.A., Esyunina D., Murakami K.S.,  & Kulbachinskiy A. "Programmable RNA targeting by bacterial Argonaute nucleases with unconventional guide binding and cleavage specificity." Nature Communications, 13, 4624, 2022. doi: 10.1038/s41467-022-32079-5. Instrument: ID7B2 (HPBio MX & FlexX)
  17. Li Y., Li Q., Gillilan R.E., Abbaspourrad A. "Reversible disassembly-reassembly of C-phycocyanin in pressurization-depressurization cycles of high hydrostatic pressure". Int. J. Biol Macromol, 253, Pt. 8, 127623. doi: 10.1016/j.ijbiomac.2023.127623. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  18. Liu D., Feng S., Huang Q., Sun S., Dong G., Long F., Milazzo M., and Wang M. "Soft, Strong, Tough, and Durable Bio-Hydrogels Via Maximizing Elastic Entropy". Adv. Funct. Mater., 2023. doi: 10.1002/adfm.202300426 Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  19. McPherson K.S., Rizzo A.A., Erlandsen H., Chatterjee N., Walker G.C., Korzhnev D.M. "Evolution of Rev7 interactions in eukaryotic TLS DNA polymerase Polζ". J. Biol. Chem., 299(2):102859, 2023. doi: 10.1016/j.jbc.2022.102859. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  20. McLeod M.J., Tran N., McCluskey G.D., Gillis T.D., Bearne S.L., Holyoak T. "A metal-dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine-5′-triphosphate." Wiley Online Library, 2023. doi: 10.1002/pro.4648. Instrument: ID7B2 (HPBio MX & FlexX)
  21. Meisburger S.P., Ando N. "Processing macromolecular diffuse scattering data." Methods Enzymol., 688, 43-86, 2023. doi: 10.1016/bs.mie.2023.06.010. Instrument: F1
  22. Meisburger S.P., Case D.A., Ando N. "Robust total X-ray scattering workflow to study correlated motion of proteins in crystals". Nat. Commun., 14, 1, 1228, 2023. doi: 10.1038/s41467-023-36734-3. Instrument: ID7B2 (HPBio MX & FlexX)
  23. Mitra S., Coopershlyak M., Li Y., Chandersekhar B., Koenig R., Chen M-T., Evans B., Heinrich F., Deslouches B., Tristram-Nagle S. "Novel Helical Trp- and Arg-Rich Antimicrobial Peptides Locate Near Membrane Surfaces and Rigidify Lipid Model Membranes." Wiley Online Library, 2023. doi: 10.1002/anbr.202300013. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  24. Page C.G., Cao J., Oblinsky D.G., MacMillan S.N., Dahagam S., Lloyd R.M., Charnock S.J., Scholes G.D. and Hyster T.K. "Regioselective Radical Alkylation of Arenes Using Evolved Photoenzymes". J. Am. Chem. Soc., 145, 21, 11866–11874, 2023. doi: 10.1021/jacs.3c03607. 
  25. Pei X., Bhatt N., Wang H., Ando N., Meisburger S.P. "Introduction to diffuse scattering and data collection." Methods Enzymol., 688, 1-42, 2023. doi: 10.1016/bs.mie.2023.07.007. Instrument: ID7B2 (HPBio MX & FlexX)
  26. Sharma S., Ebrahim A., & Keedy D. A. "Room-temperature serial synchrotron crystallography of the human phosphatase PTP1B". Acta Crystallographica Section F: Structural Biology Communications, 79, 1, Article 1, 2023.doi: 10.1107/S2053230X22011645. Instrument: ID7B2 (HPBio MX & FlexX)
  27. Tang Q., Gulkis M., Çağlayan M. "Structures of LIG1 uncover the mechanism of sugar discrimination against a ribonucleotide at 3’- and 5’-end of the nick DNA." bioRxiv preprint, doi: 10.1101/2022.08.26.505476. Instrument: ID7B2 (HPBio MX & FlexX)
  28. Tei R., Bagde S.R., Fromme J.C. & Baskin J.M. "Activity-based directed evolution of a membrane editor in mammalian cells." Nature Chemistry, 15, 1030–1039, 2023. doi:10.1038/s41557-023-01214-0. Instrument: ID7B2 (HPBio MX & FlexX)
  29. Tran, N., Dasari, S., Barwell, S.A.E., McLeod M.J., Kalyaanamoorthy S., Holyoak T., Ganesan A. "The H163A mutation unravels an oxidized conformation of the SARS-CoV-2 main protease". Nat Commun 14, 5625. 2023. doi.org: 10.1038/s41467-023-40023-4. Instrument: ID7B2 (HPBio MX & FlexX)
  30. Wang J., Koduru T., Harish B., McCallum S.A., Larsen K.P., Patel K.S., Peters E.V., Gillilan R.E., Puglisi E.V., Puglisi J.D., Makhatadze G., Royer C.A. "Pressure pushes tRNALys3 into excited conformational states." PNAS, 120, 9, 26, e2215556120, 2023. doi: 10.1073/pnas.2215556120. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  31. Watkins M.B., Wang H., Burnim A. and Ando N. "Conformational switching and flexibility in cobalamin-dependent methionine synthase studied by small-angle X-ray scattering and cryoelectron microscopy". PNAS, 120 (26), 2023. doi:10.1073/pnas.2302531120. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  32. Wittenborn E.C., Thomas W.C., Houghton K.A., Wirachman E.S., Wu Y., and Marletta M.A. "Role of the Coiled-Coil Domain in Allosteric Activity Regulation in Soluble Guanylate Cyclase." Biochemistry, 62, 10, 1568–1576, 2023. doi: 10.1021/acs.biochem.3c00052. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  33. Zhang M., Liu Y., Zuo X., Qian S., Pingali S.V., Gillilan R.E., Huang Q., and Zhang D. "pH-Dependent Solution Micellar Structure of Amphoteric Polypeptoid Block Copolymers with Positionally Controlled Ionizable Sites". Biomacromolecules, 2023. doi: 10.1021/acs.biomac.3c00407. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  34. Zhu Z., Goel P. N., Zheng C., Nagai Y., Lam L., Samanta A., Ji M., Zhang H., & Greene M. I. "HED, a Human-Engineered Domain, Confers a Unique Fc-Binding Activity to Produce a New Class of Humanized Antibody-like Molecules". International Journal of Molecular Sciences, 24,7, Article 7, 2023.doi: 10.3390/ijms24076477. Instrument: A1
  35. Zielinski K.A., Katz A.M., Calvey G.D., Pabit S.A., Milano S.K., Aplin C., Emeterio J.S., Cerione R.A., and Pollack. L. "Chaotic advection mixer for capturing transient states of diverse biological macromolecular systems with time-resolved small-angle X-ray scattering." IUCr J., 10, 3, 363-375, 2023.  doi: 10.1107/S2052252523003482. Instrument: ID7A1 (HP BioSAXS & BioSAXS)

Thesis: 

  1. Burnim Audrey A. (2023). STRUCTURAL AND PHYLOGENETIC ANALYSIS OF ALLOSTERIC REGULATION AND EVOLUTION IN THE RIBONUCLEOTIDE REDUCTASE FAMILY. Ph.D., Cornell University. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  2. Chowdhury A.A. (2023). Protein-Protein Interactions and Rheological Properties of Monoclonal Antibodies at High Concentration. Ph.D. University of Texas. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  3. Dunleavy R. (2023). Investigation of Protein Conformation with Novel Labeling Techniques using Electron Paramagnetic Resonance Spectroscopy. Ph.D. Cornell University. Instrument: ID7A1 (HP BioSAXS & BioSAXS) 
  4. Xing H. (2023). Design, Synthesis, and Characterization of Peptide Amphiphile Biomaterials. Ph.D. University of Nebraska Medical Center. Instrument: ID7A1 (HP BioSAXS & BioSAXS) 

2022

  1. Allsopp R., Pavlova A., Cline T., Salyapongse A.M., Gillilan R.E., Di Y.P., Deslouches B., Klauda J.B., Gumbart J.C., Tristram-Nagle S. "Antimicrobial Peptide Mechanism Studied by Scattering-Guided Molecular Dynamics Simulation."J. Phys. Chem. B., 126, 36, 6922-6935, 2022. doi: 10.1021/acs.jpcb.2c03193. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  2. Aplin C., Milano S.K., Zielinski K.A., Pollack L., and Cerione R.A. "Evolving Experimental Techniques for Structure-Based Drug Design." J. Phys. Chem.,  B, 126, 35, 6599–6607, 2022. doi: 10.1021/acs.jpcb.2c04344. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  3. Bonardi A., Bua S., Combs J., Lomelino C., Andring J., Osman S. M., Toti A., Di Cesare Mannelli L., Gratteri P., Ghelardini C., McKenna R., Nocentini A., & Supuran C. T. "The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII". Journal of Enzyme Inhibition and Medicinal Chemistry, 37, 1, 930–939, 2022. doi: 10.1080/14756366.2022.2053526. Instrument: F1
  4. Bozdag M., Cravey L., Combs J., Kota A., McKenna R., Angeli A., Selleri S., Carta F., & Supuran C. T. "Small Molecule Alkoxy Oriented Selectiveness on Human Carbonic Anhydrase II and IX Inhibition". ChemMedChem, 17, 11, 2022. doi: 10.1002/cmdc.202200148. Instrument: F1
  5. Burnim A.A., Spence M.A., Xu D., Jackson C.J. & Ando N. "Comprehensive phylogenetic analysis of the ribonucleotide reductase family reveals an ancestral clade. eLife 11, e79790, 2022. doi: 10.7554/eLife.79790. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  6. Caglayan M., Tang Q., Gulkis M. "Structures of LIG1 uncover a lack of sugar discrimination against a ribonucleotide at the 3'-end of nick DNA", Research Square preprint, 2022. doi:10.21203/rs.3.rs-1998177/v1. Instrument: ID7B2 (HPBio MX & FlexX)
  7. Doll S.G., Meshkin H., Bryer A.J., Li F., Ko Y.H., Lokareddy R.K., Gillilan R.E., Gupta K., Perilla J.R., Cingolani G. "Recognition of the TDP-43 nuclear localization signal by importin α1/β." Cell Rep., 28, 39, 13, 111007, 2022. doi:10.1016/j.celrep.2022.111007. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  8. Florio T.J., Lokareddy R.K., Yeggoni D.P., Sankhala R.S., Ott C.A., Gillilan R.E., Cingolani G. "Differential recognition of canonical NF-κB dimers by Importin α3". Nat. Commun., 8, 13, 1, 1207, 2022. doi: 10.1038/s41467-022-28846-z . Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  9. Gibson J.M., Cui H., Ali M.Y., Zhao X., Debler E.W., Zhao J., Trybus K.M., Solmaz R., Wang C. "Coil-to-α-helix transition at the Nup358-BicD2 interface activates BicD2 for dynein recruitment." Structural Biology and Molecular Biophysics, 2022. doi: 10.7554/eLife.74714. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  10. Gillilan R.E. "High-pressure SAXS, deep life, and extreme biophysics". Methods in Enzymology (Academic Press, 2022. doi:10.1016/bs.mie.2022.08.025. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  11. Kozlov G., Mattijssen S., Jiang J., Nyandwi S., Sprules T., Iben J. R., Coon, S. L., Gaidamakov S., Noronha A. M., Wilds C. J., Maraia R. J., & Gehring K. "Structural basis of 3’-end poly(A) RNA recognition by LARP1". Nucleic Acids Research, 50, 16, 9534–9547. 2022. doi: 10.1093/nar/gkac696. Instrument: ID7B2 (HPBio MX & FlexX)
  12. Lisitskaya L., Shin Y., Agapov A., Olina A., Kropocheva E., Ryazansky S., Aravin A. A., Esyunina D., Murakami K. S., & Kulbachinskiy A. "Programmable RNA targeting by bacterial Argonaute nucleases with unconventional guide binding and cleavage specificity". Nature Communications, 13, 1, Article 1. 2022. doi: 10.1038/s41467-022-32079-5. Instrument: ID7B2 (HPBio MX & FlexX)
  13. Lokareddy R.K., Hou C-F.D., Doll S.G., Li F., Gillilan R.E., Forti F., Horner D.S., Briani F., Cingolani G. "Terminase Subunits from the Pseudomonas-Phage E217". J. Mol. Biol., 167799, 2022. doi: 10.1016/j.jmb.2022.167799. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  14. Lussier-Price M., Wahba H. M., Mascle X. H., Cappadocia L., Bourdeau V., Gagnon C., Igelmann S., Sakaguchi K., Ferbeyre G., & Omichinski J. G. "Zinc controls PML nuclear body formation through regulation of a paralog specific auto-inhibition in SUMO1". Nucleic Acids Research, 50, 4, 8331–8348, 2022. doi: 10.1093/nar/gkac620. Instrument: F1 
  15. Marshall C. J., Qayyum M. Z., Walker J. E., Murakami K. S., & Santangelo T. J. "The structure and activities of the archaeal transcription termination factor Eta detail vulnerabilities of the transcription elongation complex". Proceedings of the National Academy of Sciences, 119, 32, 2022. doi: /10.1073/pnas.2207581119. Instrument: F1
  16. Maschmann Z. A., Chua T. K., Chandrasekaran S., Ibáñez H., & Crane B. R. "Redox properties and PAS domain structure of the Escherichia coli energy sensor Aer indicate a multistate sensing mechanism. Journal of Biological Chemistry", 298, 12, 102598, 2022. doi: 10.1016/j.jbc.2022.102598 Instrument: ID7B2 (HPBio MX & FlexX)
  17. Meisburger S.P., Case D.A., Ando N. "Robust total X-ray scattering workflow to study correlated motion of proteins in crystals".  bioRxiv preprint, 2022. doi:10.1101/2022.08.22.504832. Instrument: ID7B2 (HPBio MX & FlexX)
  18. Milano S.K., Huang Q., Nguyen T-T.T, Ramachandran S., Finke A., Kriksunov I., Schuller D.J., Szebenyi D.M., Arenholz E., McDermott L.E., Sukumar N., CerioneR.A., and Katt W.P. "New insights into the molecular mechanisms of glutaminase C inhibitors in cancer cells using serial room temperature crystallography" J. Biol. Chem., 298, 101535; 2022. doi:10.1016/j.jbc.2021.101535 Instrument: ID 7B2 (HPBio MX & FlexX)
  19. Milano S.K., Szebenyi M.D., Cerione A.R.A. "Serial Room Temperature Crystal Loading, Data Collection, and Data Processing of Human Glutaminase C in Complex with Allosteric Inhibitors." Bio. Protoc., 2022. doi: 10.21769/BioProtoc.4509. Instrument: ID 7B2 (HPBio MX & FlexX)
  20. Miller R.C., Cummings C., Huang Q., Ando N., Gillilan R.E. "Inline small-angle X-ray scattering-coupled chromatography under extreme hydrostatic pressure". Protein Science, 31, 2022. doi:10.1002/pro.4489 Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  21. Narayanan A., Narwal M., Majowicz S. A., Varricchio C., Toner S. A., Ballatore C., Brancale A., Murakami K. S., & Jose J. "Identification of SARS-CoV-2 inhibitors targeting Mpro and PLpro using in-cell-protease assay". Communications Biology, 5, 1, 1, 2022. doi: 10.1038/s42003-022-03090-9. Instrument: ID7B2 (HPBio MX & FlexX)
  22. Nguyen P., Eshaque R., Garland B. A., Dang A., & Suits M. D. L. "Degradation of chondroitin sulfate A by a PUL-like operon in Tannerella forsythia". PLOS ONE, 17, 9, 2022. doi:10.1371/journal.pone.0272904. Instrument: ID 7B2 (HPBio MX & FlexX)
  23. Osipov E. M., Munawar A. H., Beelen S., Fearon D., Douangamath A., Wild C., Weeks S. D., Aerschot A. V., Delft F. von, & Strelkov V. S. "Discovery of novel druggable pockets on polyomavirus VP1 through crystallographic fragment-based screening to develop capsid assembly inhibitors". RSC Chemical Biology, 3, 8, 1013–1027, 2022. doi: 10.1039/D2CB00052K. Instrument: F1
  24. Pedrini B., Finke A.D., Marsh M., Luporini P., Vallesi A., Alimenti C. "Crystal structure of the pheromone Er-13 from the ciliate Euplotes raikovi, with implications for a protein-protein association model in pheromone/receptor interactions". J. Struct. Biol., 214(1):107812, 2022. doi: 10.1016/j.jsb.2021.107812
  25. Schneps C.M., Ganguly A., and Crane B.R. "Room-temperature serial synchrotron crystallography of Drosophila cryptochrome." Acta Cryst., D78, 975-985, 2022. doi:10.1107/S2059798322007008 Instrument: ID7B2 (HPBio MX & FlexX)
  26. Sharma S., Ebrahim A., Keedy D.A. "Room-temperature serial synchrotron crystallography of apo PTP1B". bioRxiv preprint, 2022. doi:10.1101/2022.07.28.501725. Instrument: ID7B2 (HPBio MX & FlexX)
  27. Tang Q., Gulkis M., McKenna R. & Caglayan M. "Structures of LIG1 that engage with mutagenic mismatches inserted by polβ in base excision repair". Nature Communications, 13, 3860, 2022. doi:10.1038/s41467-022-31585-w Instrument: ID7B2 (HPBio MX & FlexX)
  28. Tei R., Bagde S.K., Fromme J.C., Baskin J.M. "Activity-based directed evolution of a membrane editor in mammalian cells". bioRxiv preprint, 2022. doi:10.1101/2022.09.26.509516. Instrument: ID7B2 (HPBio MX & FlexX)
  29. Thompson, K.D., Danielson E.P., Peterson K.N., Nocevski N.O., Boock J.T. and Berberich J.A. "The Amphoteric Surfactant N,N-Dimethyldodecylamine N-Oxide Unfolds β-Lactoglobulin above the Critical Micelle Concentration". Langmuir, 38, 4090–4101, 2022. doi:10.1021/acs.langmuir.2c00172 Instrument: G1
  30. Tran N., Dasari S., Barwell S., McLeod M.J., Kalyaanamoorthy S., Holyoak T., Ganesan A. "The H163A Mutation Unravels an Oxidized Conformation of the SARS-CoV-2 Main Protease and Opens a New Avenue for Anti-Viral Therapeutic Design." Preprint: bioRxiv, 2022. doi: 10.1101/2022.12.16.520794. Instrument: ID7B2 (HPBio MX & FlexX)
  31. Trewhella J., Vachette P., Bierma J., Blanchet C., Brookes E., Chakravarthy S., Chatzimagas L., Cleveland T.E. IV., Cowieson N., Crossett B., Duff A.P., Franke D., Gabel F., Gillilan R.E., Graewert M., Grishaev A., Guss J.M., Hammel M., Hopkins J., Huang Q., Hub J.S., Hura G.L., Irving T.C., Jeffries C.M., Jeong C., Kirby N., Krueger S., Martel A., Matsui T., Li N., Pérez J., Porcar L., Prangé T., Rajkovic I., Rocco M., Rosenberg D.J., Ryan T.M., Seifert S., Sekiguchi H., Svergun D., Teixeira S., Thureau A., Weiss T.M., Whitten A.E., Wood K.  and Zuow X. "A round-robin approach provides a detailed assessment of biomolecular small-angle scattering data reproducibility and yields consensus curves for benchmarking". Acta Crystallographica, D 78, 1315-1336, 2022. doi: 10.1107/S2059798322009184. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  32. Wang J., Zhang S., Zeghouf M., Cherfils J., McCallum A.A., Richard E.Gillilan R.E., Royer C.A. "Pressure study reveals conformational landscapes and structural transitions of small GTPase". Biophysical Journal, 121, 3, 1, 181a, 2022. doi:10.1016/j.bpj.2021.11.1833 Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  33. Xing H., Rodger A., Comer J., Picco A.S., Huck-Iriart C., Ezell E.L., and Conda-Sheridan M. "Urea-Modified Self-Assembling Peptide Amphiphiles That Form Well-Defined Nanostructures and Hydrogels for Biomedical Applications."ACS Appl. Bio Mater, 5, 10, 4599–4610, 2022. doi: 10.1021/acsabm.2c00158. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  34. Xu A.Y., Clark N.J., Pollastrini J., Espinoza M., Kim H-J., Kanapuram S., Kerwin B., Treuheit M.J., Krueger S., McAuley A. and Curtis J.E. "Effects of Monovalent Salt on Protein-Protein Interactions of Dilute and Concentrated Monoclonal Antibody Formulations". Antibodies, 11, 24, 2022. doi:10.3390/antib11020024 Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  35. Zhang S., McCallum S.A., Gillilan R.E., Wang J., Royer C.A. "High Pressure CPMG and CEST Reveal That Cavity Position Dictates Distinct Dynamic Disorder in the PP32 Repeat Protein". J. Phys. Chem. B., 126, 50, 10597-10607, 2022. doi: 10.1021/acs.jpcb.2c05498. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  36. Zovo K., Pupart H., Wieren A.V., Gillilan R.E., Huang Q., Majumdar S., and Lukk T. "Substitution of the Methionine Axial Ligand of the T1 Copper for the Fungal-like Phenylalanine Ligand (M298F) Causes Local Structural Perturbations that Lead to Thermal Instability and Reduced Catalytic Efficiency of the Small Laccase from Streptomyces coelicolor A3(2)". ACS Omega, 7(7), 6184–6194, 2022. doi: 10.1021/acsomega.1c06668. Instrument: ID7A1 (HP BioSAXS & BioSAXS)

Thesis: 

  1. Chapman D. (2022). INFORMED DESIGN OF POLYMER-SELECTIVE NANOPROBES FOR OPTICAL  SUPER-RESOLUTION MICROSCOPY. Cornell University. 
  2. Cui H. (2022). Mechanistic Insights into Auto-Inhibition of the Dynein Adaptor Bicaudal D. Ph.D. Binghamton University. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  3. Doll S.J. (2022). Recognition of the TDP-43 Nuclear Localization Signal by Importin α1/β.  Ph.D. Thomas Jefferson University. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  4. Lee R. (2022). DESIGN, SYNTHESIS, AND CHARACTERIZATION OF ULTRASMALL FLUORESCENT CORE-SHELL SILICA NANOPARTICLES FOR BIOLOGICAL IMAGING AND SENSING APPLICATIONS. Cornell University
  5. Li, Y. (2022). Photoactive C-Phycocyanin Assemblies: From Food Colorants to Tunable Biofunctional Materials. Ph.D. Cornell University. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  6. Nguyen T.T.T. (2022). The Allosteric Regulation of Glutaminase Enzymes: Driving Glutamine Catabolism in Cancer Cells. Ph.D. Cornell University. Instrument: ID 7B2 (HPBio MX & FlexX)
  7. Penhallurick R.W. (2022). Pressure Adaptations in Deep-Sea Dihydrofolate Reductases. Ph.D.  Georgetown University. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  8. Potter J. (2022). Studying the Structure and Interactions of the Globin-Coupled Sensor in P. carotovorum. Ph.D. Penn State University. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  9. San Emeterio J. (2022). STRUCTURAL STUDIES OF VIRAL RNA THROUGH SMALL ANGLE X-RAY SCATTERING AND CONTRAST VARIATION. Ph. D., Applied Physics. Cornell University. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  10. Sarracini A. (2022). Time-Resolved Electron and Serial X-Ray Crystallography of PbS Quantum Dots and Biomolecules. Ph.D. University of Toronto (Canada). Instrument: G3
  11. Schneps C.M. (2022). Understanding Light-Regulation by CRYPTOCHROME: A Structural Story. Ph.D. Cornell University. Instrument: ID7B2 (HPBio MX & FlexX)
  12. Tariq D. (2022). Investigating The Structural Properties of Repressors in The Neurospora crassa Circadian Clock. Cornell University.
  13. Wang J. (2022). STUDYING TERTIARY STRUCTURAL TRANSITIONS OF TRNALYS3 AND ARF1 PROTEIN WITH PRESSURE. Rensselaer Polytechnic Institute. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  14. Watkins M.B. (2022). CONFORMATIONAL CONTROL OF REACTIVITY IN HIGHLY FLEXIBLE ENZYMES STUDIED BY SAXS AND CRYO-EM. Ph.D. Cornell University. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  15. Winnikoff J. R. (2022). Adaptation to High Hydrostatic Pressure in Ctenophores. Ph.D. UC Santa Cruz. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  16. Zhang S. (2022). Investigating the conformational dynamics and invisible excited states of cavity-containing mutants of a repeat protein with pressure perturbation methods. Rensselaer Polytechnic Institute. Instrument: ID7A1 (HP BioSAXS & BioSAXS)

2021

  1. Ando N., Barquera B., Bartlett D.H., Boyd E., Burnim A.A., Byer A.S., Colman D., Gillilan R.E., Gruebele M., Makhatadze G., Royer C.A., Shock E., Wand A.J. and Watkins M.B. "The Molecular Basis for Life in Extreme Environments". Annu. Rev. Biophys, 50:343-372. 2021. DOI: 10.1146/annurev-biophys-100120-072804. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  2. Beaucage P.A., Van Dover R.B., DiSalvo F.J., Gruner S.M., Wiesner U. "Superconducting Quantum Metamaterials from Convergence of Soft and Hard Condensed Matter Science." Adv Mater, 33, 26, 2021. doi: 10.1002/adma.202006975 Instrument: G1
  3. Cho E-A., Zhang P., Kumar V., Huang Q., Duncan J.S., Wu J. "Phosphorylation of RIAM by src promotes integrin activation by unmasking the PH domain of RIAM." Structure., 29, 4, 320-329, E4, 2021. DOI: 10.1016/j.str.2020.11.011. Instrument: ID 7B2 (HPBio MX & FlexX)
  4. Clinger J.A., Moreau D.W., McLeod M.J., Holyoak T., Thorne R.E. "Millisecond Mix-and-Quench Crystallography (MMQX) Enables Time-Resolved Studies of PEPCK With Remote Data Collection". bioRxiv. DOI: 10.1101/2021.04.06.438620. Instrument: ID 7B2 (HPBio MX & FlexX)
  5. Cunci L., González-Colón V., Vargas-Pérez B.L., Ortiz-Santiago J., Pagán M., Carrion P., Cruz J., Molina-Ontoria A., Martinez N., Silva W., Echegoyen L. and Cabrera C.R. "Multicolor Fluorescent Graphene Oxide Quantum Dots for Sensing Cancer Cell Biomarkers." ACS Appl. Nano Mater., 4, 1, 211–219, 2021. DOI: 10.1021/acsanm.0c02526 Instrument: F2
  6. Dagenais P., Desjardins G., Legault P. "An integrative NMR-SAXS approach for structural determination of large RNAs defines the substrate-free state of a trans-cleaving Neurospora Varkud Satellite ribozyme." Nucleic Acids Research, 49, 20, 11959–11973, 2021. doi: 10.1093/nar/gkab963. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  7. Gibson J.M., Cui H., Ali M.Y., Zhao X., Debler E.W., Zhao J., Trybus K.M., Solmaz S.R., and Wang C. "Coil-to-Helix Transition at the Nup358-BicD2 Interface for Dynein Recruitment and Activation." bioRxiv, 2021. DOI: 10.1101/2021.05.06.443034 Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  8. Harish B., Gillilan R.E., Zou J., Wang J., Raleigh D.P., Royer C.A. "Protein unfolded states populated at high and ambient pressure are similarly compact". Biophysical Journal,120, 2592–2598, 2021. doi: 10.1016/j.bpj.2021.04.031 ID7A1 (HP BioSAXS & BioSAXS)
  9. Harrison J.J.E.K., Tuske S., Das K., Ruiz F.X., Bauman J.D., Boyer P.L., DeStefano J.J., Hughes S.H., and Arnold E. "Crystal Structure of a Retroviral Polyprotein: Prototype Foamy Virus Protease-Reverse Transcriptase (PR-RT)." Viruses, 13(8), 1495, 2021. doi: 10.3390/v13081495. Instrument: F1.
  10. Illava G., Jayne R., Finke A.D., Closs D., Zeng W., Milano S.K., Huang Q., Kriksunov I.A., Sidorenko P., Wise F.W., Zipfel W.R., Apker B.A. and Thorne R.E. "Integrated sample-handling and mounting system for fixed-target serial synchrotron crystallography." Acta Cryst., D77, 628-644, 2021 DOI: 10.1107/S2059798321001868. Instrument: ID 7B2 (HPBio MX & FlexX)
  11. Kelly C.M., Byrnes L.J., Neela N., Sondermann H., O'Donnell J.P. "The hypervariable region of atlastin-1 is a site for intrinsic and extrinsic regulation." J. Cell Biol., 1, 220, 11, 2021. doi:10.1083/jcb.202104128. Instrument: A1 and F1.
  12. Li Y., Gillilan R., and Abbaspourrad A. "Tuning C-Phycocyanin Photoactivity via pH-Mediated Assembly–Disassembly". Biomacromolecules, 22, 12, 5128–5138, 2021. DOI: 10.1021/acs.biomac.1c01095 Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  13. Liu Y., Moural T., Koirala BK S., Hernandez J., Shen Z., Alyokhin A., Zhu F. "Structure and function of one unclassified-class glutathione S-transferase in Leptinotarsa decemlineata." Int. J. Mol. Sci., 22, 21, 11921, 2021. doi: 10.3390/ijms222111921. Instrument: ID 7B2 (HPBio MX & FlexX)
  14. Lormand J.D., Kim S-K., Walters-Marrah G.A., Brownfield B.A., Fromme J.C., Winkler W.C., Goodson J.R., Lee V.T., Sondermann H. "Structural characterization of NrnC identifies unifying features of dinucleases." 2021. doi:  10.7554/eLife.70146. Instrument: ID 7B2 (HPBio MX & FlexX) 
  15. Losada N., Ruiz F.X., Curreli F., Gruber K., Pilch A., Das K., Debnath A.K., and Arnold E. "HIV-1 gp120 Antagonists Also Inhibit HIV-1 Reverse Transcriptase by Bridging the NNRTI and NRTI Sites." J. Med. Chem., 64, 22, 16530–16540, 2021. doi: 10.1021/acs.jmedchem.1c01104. Instrument: ID 7B2 (HPBio MX & FlexX)
  16. Mäkinen J.J., Shin Y., Vieras E., Virta E.P., Metsä-Ketelä M., Murakami K.S. & Belogurov G.A. "The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases." Nat Commun., 12, 796, 2021. doi: 10.1038/s41467-021-21005-w. Instrument: F1
  17. Mboge M.Y., Combs J., Singh S., Andring J., Wolff A., Tu C., Zhang Z., McKenna R., and Frost S.C. "Inhibition of Carbonic Anhydrase Using SLC-149: Support for a Noncatalytic Function of CAIX in Breast Cancer." J. Med. Chem., 64, 3, 1713–1724, 2021. doi: 10.1021/acs.jmedchem.0c02077. Instrument: F1
  18. Moreau D.W., Atakisi H., and Thorne R.E. "Ice in biomolecular cryocrystallography." Acta Cryst., 77, 540-554, 2021. doi: 10.1107/S2059798321001170. Instrument: F1
  19. Namitz K.E.W., Zheng T., Canning A.J., Alicea-Velazquez N.L., Castañeda C.A., Cosgrove M.S., & Hanes S.D. "Structure analysis suggests Ess1 isomerizes the carboxy-terminal domain of RNA polymerase II via a bivalent anchoring mechanism." Commun Biol., 4, 398, 2021. doi: 10.1038/s42003-021-01906-8. Instrument: F1
  20. Patterson D.C., Ruiz M.P., Hyerin Yoon H., Walker J.A., Armache J-P., Yennawar N.H., and Weinert E.E. "Differential ligand-selective control of opposing enzymatic activities within a bifunctional c-di-GMP enzyme." PNAS, 2021. doi: 10.1073/pnas.210065711. Instrument: ID7A1 (HP BioSAXS & BioSAXS) 
  21. Pudasaini A., Green R., Song Y.H., Blumenfeld A., Karki N., Imaizumi T. and Zoltowski B.D. "Steric and Electronic Interactions at Gln154 in ZEITLUPE Induce Reorganization of the LOV Domain Dimer Interface." Biochemistry, 60, 2, 95–103, 2021. doi: 10.1021/acs.biochem.0c00819 Instrument: F1
  22. Rai D.K., Gillilan R.E., Huang Q., Miller R., Ting E., Lazarev A., Tate M.W. and Gruner S.M. High-pressure small-angle X-ray scattering cell for biological solutions and soft materials. J. Appl. Cryst., 54, 111-122, 2021. DOI: 10.1107/S1600576720014752. Instrument: ID7A1 (HP BioSAXS & BioSAXS) 
  23. Shin Y., Murakami K.S. "Watching the bacterial RNA polymerase transcription reaction by time-dependent soak-trigger-freeze X-ray crystallography." The Enzymes, 49, 305-314, 2021. doi: 10.1016/bs.enz.2021.06.009. Instrument: F1.
  24. Srivastava Y., Bonn-Breach R., Chavali S.S., Lippa G.M., Jenkins J.L. and Wedekind J.E. "Affinity and Structural Analysis of the U1A RNA Recognition Motif with Engineered Methionines to Improve Experimental Phasing." Crystals, 11, 3, 2021. doi: 10.3390/cryst11030273. Instrument: G1
  25. Torabi S-F., Chen Y-L., Zhang K., Wang J.,  DeGregorio S.J., Vaidya A.T., Su Z., Pabit S.A., Chiu W., Pollack L., and Steitz J.A. "Structural analyses of an RNA stability element interacting with poly (A)." Proceedings of the National Academy of Sciences 118, 14, 2021. doi: 10.1073/pnas.2026656118  Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  26. Turk L.S., Kuang X., Dal Pozzo V., Patel K., Chen M.,  Huynh K., Currie M.J., Mitchell D., Dobson R.C.J., D'Arcangelo G., Dai W., Comoletti D. "The structure-function relationship of a signaling-competent, dimeric Reelin fragment." Structure, 29, 10, 1156-1170, 2021. doi: 10.1016/j.str.2021.05.012 Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  27. Werner J.G., Lee H., Wiesner U., and Weitz D.A. "Ordered Mesoporous Microcapsules from Double Emulsion Confined Block Copolymer Self-Assembly." ACS Nano, 15, 2, 3490–3499, 2021. doi: 10.1021/acsnano.1c00068. Instrument: G1
  28. Zhao J., Blayney A., Liu X., Gandy L., Jin W., Yan L., Ha J-H., Canning A.J., Connelly M., Yang C., Liu X., Xiao Y., Cosgrove M.S., Solmaz S.R., Zhang Y., Ban D., Chen J., Loh S.N., Wang C. "EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction." Nature Communications., 12: 986. Published online 2021. DOI: 10.1038/s41467-021-21258-5.  Instrument: ID7A1 (HP BioSAXS & BioSAXS)

Thesis: 

  1. Atakisi H. (2021). Temperature, Cooling Rate and Hydration Dependence of Protein Conformational Ensembles and Radiation Damage in Biomolecular X-Ray Crystallography. Ph.D. Cornell University. Instrument: A1, F1, F3
  2. Florio T.J. (2021). Mechanisms and Regulation of NF-κB Nuclear Import Through Importin α Isoforms. Ph.D. Thomas Jefferson University. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  3. Noell C.R. (2021). Investigating Cargo-Recognition and Activation of Dynein Adapter Protein BicD2 and Its Role in Neuromuscular Diseases. Ph.D. State University of New York at Binghamton. Instrument: F1
  4. Paré-Labrosse O. (2021). Damage-Free Femtosecond Structural Dynamics of Proteins in the Biologically Relevant Regime. Ph.D. University of Toronto (Canada). Instrument: G3
  5. Patterson D.C. (2021). Characterization of a bifunctional globin coupled sensor protein. Penn State University. Ph.D. Instrument: ID7A1 (HP BioSAXS & BioSAXS)
  6. Thomas W.C. (2021). Convergent Allostery in Bacillus subtilis Ribonucleotide Reductase Studied by SAXS, Crystallography, and Cryo-EM. Ph.D. Princeton University. Instrument: ID7A1 (HP BioSAXS & BioSAXS)

2020

  1. Andring J.T., Fouch M., Akocak S., Angeli A., Supuran C.T., Ilies M.A., and McKenna R. "Structural Basis of Nanomolar Inhibition of Tumor-Associated Carbonic Anhydrase IX: X-Ray Crystallographic and Inhibition Study of Lipophilic Inhibitors with Acetazolamide Backbone." J. Med. Chem., 63, 21, 13064–13075, 2020. doi: 10.1021/acs.jmedchem.0c01390. Instrument: F1
  2. Bonardi A., Nocentini A., Silvia Bua S., Combs J., Lomelino C., Andring J., Lucarini L., Sgambellone S., Masini E., McKenna R., GratteriP., and Supuranv C.T. "Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action." J. Med. Chem., 63, 13, 7422–7444, 2020. doi: 10.1021/acs.jmedchem.0c00733. Instrument: F1
  3. Bua S., Lomelino C., Murray A.B., Osman S.M., ALOthman Z.A., Bozdag M., Abdel-Aziz H.A., Eldehna W.M., McKenna R., Nocentini A., Supuran C.T. "A Sweet Combination": Developing Saccharin and Acesulfame K Structures for Selectively Targeting the Tumor-Associated Carbonic Anhydrases IX and XII." J. Med. Chem. 2020 Jan 9;63(1):321-333. doi: 10.1021/acs.jmedchem.9b01669. Instrument: F1
  4. Chen YS, Kozlov G, Fakih R, Yang M, Zhang Z, Kovrigin EL, Gehring K. "Mg2+-ATP Sensing in CNNM, a Putative Magnesium Transporter". Structure, 28(3), 324-335.e4.  2020; doi: 10.1016/j.str.2019.11.016. Instrument F1.
  5. Coombs S.E., Banjade S., Kriksunov K., Clemente N., Zhao J., Wang C., Gillilan R.E., Oswald R.E. "In Vitro Effects of (+)MK-801 (dizocilpine) and Memantine on β-Amyloid Peptides Linked to Alzheimer's Disease", Biochemistry, 59, 48, 4517-4522, 2020. PMID: 33249825, doi: 10.1021/acs.biochem.0c00813. Instrument: G1
  6. Eisemann T.J., Allen F., Laue K., Shimamura G.R., Jeffrey P.D., Hughson F.M. "The Sec1/Munc18 protein Vps45 holds the Qa-SNARE Tlg2 in an open conformation", Elife, 9:e60724, 2020. doi: 10.7554/eLife.60724, Instrument F1
  7. Gandhi S., Baker R.P., Cho S., Stanchev S., Strisovsky K., Urban S. "Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria", Cell Chem Biol 27: 1410-1424 (2020). PMID: 32888502, PMCID: PMC7680425, DOI: 10.1016/j.chembiol.2020.08.01. Instrument: ID7B2
  8. Goodwin C.A.P., Réant B.L.L., Vettese G.F., Kragskow J.G.C., Giansiracusa M.J., DiMucci I.M., Lancaster K.M., Mills D.P., and Sproules S. "Heteroleptic Samarium(III) Chalcogenide Complexes: Opportunities for Giant Exchange Coupling in Bridging σ- and π-Radical Lanthanide Dichalcogenides." Inorg. Chem., 59, 11, 7571–7583, 2020. doi: 10.1021/acs.inorgchem.0c00470. 
  9. Hashimoto H., Kafkova L., Raczkowski A., Jordan K.D., Read L.K., Debler E.W. "Structural Basis of Protein Arginine Methyltransferase Activation by a Catalytically Dead Homolog (Prozyme)". J. Mol. Biology, 432, 2;410-426, (2020); DOI: 10.1016/j.jmb.2019.11.002; Published: JAN 17 2020, Instrument: F1
  10. Haupenthal J., Kautz Y., Elgaher W.A.M., Pätzold L., Röhrig T., Laschke M.W., Tschernig T., Hirsch A.K.H., Molodtsov V., Murakami K.S., Hartmann R.W. and Bischoff M. "Evaluation of Bacterial RNA Polymerase Inhibitors in a Staphylococcus aureus-Based Wound Infection Model in SKH1 Mice." ACS Infect. Dis., 6, 10, 2573-2581, 2020 doi: 10.1021/acsinfecdis.0c00034. Instrument: F1
  11. Hosford C.J., Q. Bui A.Q., Chappie J.S. "The structure of the Thermococcus gammatolerans McrB N-terminal domain reveals a new mode of substrate recognition and specificity among McrB homologs." PROTEIN STRUCTURE AND FOLDING, 295, 13, 743-756, 2020. doi: 10.1016/S0021-9258(17)49932-7. Instrument: F1
  12. Huang, Q., Szebenyi, D. "Crystal structure of Snf7 under 200 MPa". To be published, 2020,
  13. Hsiao H-h. T., Crichlow G.V., Murphy J.W., Folta-Stogniew E.J., Lolis E.J., Braddock D.T. "Unraveling the mechanism of recognition of the 3’ splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60." PLOS One, 2020. doi: 10.1371/journal.pone.0242725. Instrument: A1
  14. Jun S.-H., Hyun J., Cha J.S, Kim H., Bartlett M.S., Cho H-S. & Murakami K.S. "Direct binding of TFEα opens DNA binding cleft of RNA polymerase." Nature Communications, 11, 2020. DOI: 10.1038/s41467-020-19998-x. Instrument: A1
  15. Kim J.K., Lee C., Lim S.W., Andring J.T., Adhikari A., McKenna R., Kim C.U. "Structural insights into the effect of active-site mutation on the catalytic mechanism of carbonic anhydrase", IUCrJ 7: 985-994,  2020. doi: 10.1107/S2052252520011008. Instrument: F1
  16. Koruza K., Murray A.B., Mahon B.P., Hopkins J.B., W.K., McKenna R.  and Fisher S.Z. "Biophysical Characterization of Cancer-Related Carbonic Anhydrase IX." Int. J. Mol. Sci., 21, 15, 5277, 2020. doi: 10.3390/ijms21155277. Instrument: G1
  17. Kosciuk, T., Price, I., Zhang, X., Zhu, C., Johnson, K., Zhang, S., Halaby, S., Komaniecki, G., Yang, M., DeHar, C.,  Thomas, P., Kelleher, N., Fromme, J.C.,  and Lin, H. "NMT1 and NMT2 are Lysine Myristoyltransferases Regulating the ARF6 GTPase Cycle" Nature Communications 11 (2020) 1067; DOI: 10.1038/s41467-020-14893-x. Instrument F1
  18. Kozlov G., Funato Y., Chen, Y.S., Zhang Z., Illes K., Miki H., Gehring K. "PRL3 phosphatase activity is necessary and sufficient to promote metastatic growth", J Biol Chem 295: 11682-11692 (2020). PMID: 32571875, PMCID: PMC7450121 (available on 2021-8-14), DOI: 10.1074/jbc.RA120.014464. Instrument: F1
  19. Kumar S., Gillilan R.E., Yernool D.A. "Structure and function of the juxtamembrane GAF domain of potassium biosensor KdpD", Protein Sci., 29, 9, 2009-2021, 2020. doi: 10.1002/pro.3920. Instrument: F2
  20. Lee I.G., Cason S.E., Alqassim S.S., Holzbaur E.L.F & Dominguez R. "A tunable LIC1-adaptor interaction modulates dynein activity in a cargo-specific manner". Nat Commun., 11, 5695, 2020. doi:  10.1038/s41467-020-19538-7. Instrument: F1
  21. Li L., Molodtsov V., Lin W., Ebright R.H., Zhang Y. “RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription”. PNAS 117, 5801-5809, 2020; DOI: 10.1073/pnas.1920747117. Instrument: F1
  22. Liu J., Kozhaya L., Torres V.J., Unutmaz D., Lu M. "Structure-based discovery of a small-molecule inhibitor of methicillin-resistant Staphylococcus aureus virulence."  MOLECULAR BASES OF DISEASE  295, 18, 5944-5959,  2020. doi: 10.1074/jbc.RA120.012697. Instrument: F1
  23. Lussier-Price M., Mascle X.H., Cappadocia L., Kamada R., Sakaguchi K., Wahba H.M. Omichinski J.G. "Characterization of a C-terminal SUMO-interacting motif present in select PIAS-family proteins", Structure, 28, 573-585, 2020. doi: 10.1016/j.str.2020.04.002. Instrument: F1
  24. Mascle X.H., Gagnon C., Wahba H.M., Lussier-Price M., Cappadocia L., Sakaguchi K., Omichinski J.G. "Acetylation of SUMO1 Alters Interactions with the SIMs of PML and Daxx in a Protein-Specific Manner". Structure, 28, 2, 157, 2020. doi: 10.1016/j.str.2019.11.019. Instrument: F1
  25. Meisburger S.P., Case D.A. & Ando N. “Diffuse X-ray scattering from correlated motions in a protein crystal.” Nat Commun., 11, 1271, 2020; DOI: 10.1038/s41467-020-14933-6. Instrument F1
  26. Muok A.R., Chua T.K., Srivastava M., Yang W., Maschmann Z., Borbat P.P., Chong J., Zhang S., Freed J.H., Briegel A., Crane B.R. "Engineered chemotaxis core signaling units indicate a constrained kinase-off state." Sci Signal, 13, 657, 2020. doi: 10.1126/scisignal.abc1328. Instrument: G1
  27. Naseri N.N., Ergel B., Kharel P., Na Y., Huang Q., Huang R., Dolzhanskaya N., Burré J., Velinov M.T., Sharma M. "Aggregation of mutant cysteine string protein-α via Fe-S cluster binding is mitigated by iron chelators". Nat. Struct. Mol. Biol., 27, 2,192-201, 2020. DOI: 10.1038/s41594-020-0375-y Instrument F3.
  28. Niazi M., Florio T.J., Yang R., Lokareddy R.K., Swanson N,A,. Gillilan R.E., Cingolani G. "Biophysical analysis of Pseudomonas-phage PaP3 small terminase suggests a mechanism for sequence-specific DNA-binding by lateral interdigitation", Nucl Acids Res., 48, 20, 11721-11736, 2020. PMID: 33125059, PMCID: PMC7672466, doi: 10.1093/nar/gkaa866. Instrument: ID7A1
  29. Ngu L., Winters J.N., Nguyen K., Ramos K.E., DeLateur N.A., Makowski L., Whitford P.C., Ondrechen M.J., Beuning P.J. Probing remote residues important for catalysis in Escherichia coli ornithine transcarbamoylase. PloS one. 15, (2), 2020.   DOI: 10.1371/journal.pone.0228487. Instrument G1
  30. Pabit S.A, Chen Y-L, Usher E.T., Cook E.C., Pollack L., Showalter S.A. Elucidating the Role of Microprocessor Protein DGCR8 in Bending RNA Structures. Biophys J., 119(12): 2524–2536, 2020. doi: 10.1016/j.bpj.2020.10.038. Instrument G1
  31. Petreni A., Bonardi A., Lomelino C., Osman S.M., ALOthman Z.A., Eldehna W.M., El-Haggar R., McKenna R., Nocentini A., Supuran C.T. “Inclusion of a 5-fluorouracil moiety in nitrogenous bases derivatives as human carbonic anhydrase IX and XII inhibitors produced a targeted action against MDA-MB-231 and T47D breast cancer cells”. Eur J. Med. Chem. 190, 112112, 2020. doi: 10.1016/j.ejmech.2020.112112. Instrument F1
  32. Plumridge A., Andresen K., Pollack L. "Visualizing Disordered Single-Stranded RNA: Connecting Sequence, Structure, and Electrostatics". J. American Chem. Soc., 42 1;109-119 (2020); DOI: 10.1021/jacs.9b04461; Published: JAN 8 2020; Instrument: G1
  33. Rebowski G., Boczkowska M., Drazic A., Ree R., Goris M., Arnesen T., Dominguez R. "Mechanism of actin N-terminal acetylation". Science Advances, 6, 15, eaay8793,  08 Apr 2020; DOI: 10.1126/sciadv.aay8793. Instrument F1
  34. Shin J-H., Sulpizio A.G., Kelley A., Alvarez L., Murphy S.G., Fan L., Cava F., Mao Y., Saper M.A. and Dörr T. "Structural basis of peptidoglycan endopeptidase regulation". PNAS, 117, 21, 11692-11702, 2020. doi: 10.1073/pnas.2001661117. Instrument: F1
  35. Shin Y., Hedglin M., Murakami K.S. ”Structural Basis of Reiterative Transcription From the pyrG and pyrBI Promoters by Bacterial RNA Polymerase”. Nucl Acids Res 48, 2144-2155, 2020; DOI: 10.1093/nar/gkz1221 Instrument F1
  36. Singh S., McKenna R., Mboge M.Y., Wolff A., Clark S.C., Chingkuang T., Supuran C.T., Zhang Z., Frost S.C. "Selective inhibition of carbonic anhydrase IX activity, using compound SLC-149, displays limited anticancer effects in breast cancer cell lines". To be published; Instrument: F
  37. Woods D., Vangaveti S., Egbanum I., Sweeney A.M., Li Z., Bacot-Davis V., LeSassier D.S., Stanger M., Hardison G.E., Li H., Belfort M., Lennon C.W. Conditional DnaB Protein Splicing Is Reversibly Inhibited by Zinc in Mycobacteria. Molecular Biology and Physiology, DOI: 10.1128/mBio.01403-20. Instrument: F1
  38. Xiao Y., Poovaiah C., Unda F., Ritchie L., Dombrov M., Phalen C., Argyros A., Coleman H. "Expression of the Trichoderma reesei expansin-like protein, swollenin, in poplar results in biomass with improved sugar release by enzymatic hydrolysis". Biomass and Bioenergy, 134, 105473, ISSN 0961-9534, 2020. doi: 10.1016/j.biombioe.2020.105473.

Thesis: 

  1. Andring J.T. (2020). Mechanism and Inhibition of Carbonic Anhydrase. Ph.D. University of Florida. Instrument: F1
  2. Eilers G. (2020). STRUCTURAL AND BIOCHEMICAL STUDIES OF HIV-1 INTEGRATION AND INHIBITION. Ph.D. University of Pennsylvania. 
  3. Chen Y. (2020). Structural and Functional Characterization of CNNM Magnesium Transporters. Ph.D. McGill University (Canada). Instrument: F1
  4. Chen Y.L. (2020). Bridging Theories and Experiments: Modeling Solution X-ray Scattering of Small RNA Molecules. Ph.D. Cornell University. Instrument: G1
  5. Mauney A.W. (2020). NOVEL MODELING METHODS FOR STUDYING NUCLEOSOMES WITH CONTRAST VARIATION SMALL ANGLE X-RAY SCATTERING. Ph.D. Cornell University. Instrument: G1
  6. Moreau D.W. (2020). Ice Formation and Solvent Nanoconfinement in Protein Crystallography. Ph.D. Cornell University. Instrument: F1
  7. Plumridge A. (2020). Discovering design principles to re-engineer functional RNA elements using computational and microfluidic approaches. Ph.D. Cornell University. Instrument: G1
  8. Shin Y. (2020). Structural Basis of Bacterial Transcription Investigation of Mechanisms of Reiterative Transcription and Ribosomal RNA Transcription by X-ray Crystallography and Cryo-Electron Microscopy. Ph.D. The Pennsylvania State University. Instrument: F1
  9. Sutherland C. (2020). Developments in Structure Based Drug Design: A Promising Method for Targeting Rifampicin Resistant Mycobacterium tuberculosis RNA Polymerase. Ph.D. The Pennsylvania State University. 

2019

  1. Barteau K.P, Ma K., Kohle F.F.E., Gardinier T.C., Beaucage P.A., Gillilan R.E, Wiesner U. "Quantitative Measure of the Size Dispersity in Ultrasmall Fluorescent Organic-Inorganic Hybrid Core-Shell Silica Nanoparticles by Small-angle X-ray Scattering." Chemistry of Materials, 31, 3, 643–657, 2019. doi: 10.1021/acs.chemmater.8b04369. Instrument: G1 
  2. Chang Y-C., Su W., Cho E-a., Zhang H., Huang Q., Philips M.R., Wu J. "Molecular basis for auto inhibition of RIAM regulated by FAK in integrin activation." PNAS, 116, 9, 3524-3529, 2019. doi: 10.1073/pnas.1818880116. Instrument:F1
  3. Chen Y.L ., Lee T., Elber R., Pollack L. “Conformations of an RNA Helix-Junction-Helix Construct Revealed by SAXS Refinement of MD Simulations”, BIOPHYSICAL JOURNAL, 116, 1, 19-30, 2019. doi: 10.1016/j.bpj.2018.11.020, Instrument: G1
  4. Chen Y-L. and Pollack L. "Salt Dependence of A‑Form RNA Duplexes: Structures andImplications". J.Phys.Chem.B., 123, 9773−9785, 2019. doi: 10.1021/acs.jpcb.9b07502.  Instrument: G1
  5. Cho S., Baker R.P., Ji M., Urban S. "Ten catalytic snapshots of rhomboid intramembrane proteo K. " lysis from gate opening to peptide release". Nature Structural & Molecular Biology. 26, 910–918, 2019. doi: 10.1038/s41594-019-0296-9. Instrument:F1.
  6. Cook E.C., Sahu D., Bastidas M., and Showalter S.A. "Solution Ensemble of the C-Terminal Domain from the Transcription Factor Pdx1 Resembles an Excluded Volume Polymer". J. Phys. Chem., B, 123, 1, 106–116, 2019. doi: 10.1021/acs.jpcb.8b10051. Instrument: G1
  7. Das K., Martinez S.E., DeStefano J.J. and Arnold E. "Structure of HIV-1 RT/dsRNA initiation complex prior to nucleotide incorporation." PNAS, 116, 7308-7313, 2019. doi: 10.1073/pnas.1814170116. Instrument: F1
  8. Dong L., Anderson A.J., Malkowski M.G. “Arg-513 and Leu-531 Are Key Residues Governing Time-Dependent Inhibition of Cyclooxygenase-2 by Aspirin and Celebrex”, Biochemistry 58, 3990-4002, 2019.doi: 10.1021/acs.biochem.9b00659; Instrument G1
  9. Ernits K., Eek P., Lukk T., Visnapuu T. & Alamäe  T. " First crystal structure of an endo-levanase – the BT1760 from a human gut commensal Bacteroides thetaiotaomicron". Scientific Reports, 9, 8443, 2019. doi: 10.1038/s41598-019-44785-0. Instrument: F1.
  10. Florio T.J., Lokareddy R.K., Gillilan R.E., Cingolani G. "Molecular Architecture of the Inositol Phosphatase Siw14." Biochemistry, 58, 6, 534-545, 2019.  doi:10.1021/acs.biochem.8b01044. Instrument: G1
  11. Jang, H (Jang, Hyunbum); Banerjee, A (Banerjee, Avik); Marcus, K (Marcus, Kendra); Makowski, L (Makowski, Lee); Mattos, C (Mattos, Carla); Gaponenko, V (Gaponenko, Vadim); Nussinov, R (Nussinov, Ruth); "The Structural Basis of the Farnesylated and Methylated KRas4B Interaction with Calmodulin." STRUCTURE, 27, 11, 1647, 2019. doi: 10.1016/j.str.2019.08.009; Instrument: G1
  12. Kast D.J. & Dominguez R. "Mechanism of IRSp53 inhibition by 14-3-3". Nat Commun., 10, 483, 2019; DOI: 10.1038/s41467-019-08317-8 Instrument: A1.
  13. Khan C.A., Meisburger S.P.,  Ando N., Fitzpatrick P.F. “The phenylketonuria-associated substitution R68S converts phenylalanine hydroxylase to a constitutively active enzyme but reduces its stability”. JOURNAL OF BIOLOGICAL CHEMISTRY, 294, 12, 4359-4367, 2019. doi: 10.1074/jbc.RA118.006477, Instrument: G1
  14. Kim S-K.,  Lormand J.D.,  Weiss C.A., Eger K.A., Turdiev H.,  Winkler W.C., Sondermann H., Lee V.T.  "A dedicated diribonucleotidase resolves a key bottleneck for the terminal step of RNA degradation". Elife. 2019. doi: doi.org/10.7554/eLife.46313. Instrument: F1.
  15. Kitts G., Giglio K.M., Zamorano-Sánchez D., Park J.H., Townsley L., Cooley R.B., Wucher B.R., Klose K.E., Nadell C.D., Yildiz F.H., Sondermann H. "A Conserved Regulatory Circuit Controls Large Adhesins in Vibrio cholerae". ASM Journals, mBio, 10, 6. 2019. doi: 10.1128/mbio.02822-19. Instrument: A1
  16. Kumagai A., Dupuy F.G., Arsov Z., Elhady Y., Moody D., Ernst R.K., Deslouches B., Montelaro R.C., Di Y.P., Tristram-Nagle S. “Elastic behavior of model membranes with antimicrobial peptides depends on lipid specificity and D-enantiomers”, SOFT MATTER, 15, 8, 1860-1868, 2019. doi: 10.1039/c8sm02180e, Instrument: G1
  17. Leamy K.A., Yamagami R., Yennawar N.H., and Bevilacqua P.C. "Single-nucleotide control of tRNA folding cooperativity under near-cellular conditions." PNAS, 12, 16, 46, 23075-23082, 2019. doi: 10.1073/pnas.191341811 Instrument: G1
  18. Lomelino C.L. and McKenna R. "Carbonic anhydrase II in complex with carboxylic acid-based inhibitors"., Acta Crystallographica, F, v. 75|, 3, 166-170, 2019. doi: 10.1107/S2053230X18018344. Instrument: F1
  19. Lynch M.J., Miller M., James M., Zhang S., Zhang K., Li C., Charon N.W., Crane B.R. "Structure and chemistry of lysinoalanine crosslinking in the spirochaete flagella hook." Nat Chem Biol., 15, 959–965, 2019. doi: 10.1038/s41589-019-0341-3. Instrument: F1
  20. Mahanta N., Hicks K.A., Naseem S., Zhang Y., Fedoseyenko D., Ealick S.E., Begley T.P. "Menaquinone Biosynthesis: Biochemical and Structural Studies of Chorismate Dehydratase". Biochemistry, 58, 14, 1837-1840, 2019. doi: 10.1021/acs.biochem.9b00105. Instrument F1.
  21. Martinez S.E., Bauman J.D., Das K., Arnold A. "Structure of HIV‐1 reverse transcriptase/d4TTP complex: Novel DNA cross‐linking site and pH‐dependent conformational changes". Protein Science, 28, 3, 587-59, 2019. doi: 10.1002/pro.3559.  Instrument: F1
  22. Mitra A., Ko Y-H., Cingolani G. and Michael Niederweis. Niederweis M. "Heme and hemoglobin utilization by Mycobacterium tuberculosis". Nature Communications, 10, 2019. doi: 10.1038/s41467-019-12109-5. Instrument: F1.
  23. Moreau D.W., Atakisi H., and Thorn R.E. "Ice formation and solvent nanoconfinement in protein crystals". IUCrJ, 6, 3, 346-356, 2019. doi: 10.1107/S2052252519001878.  Instrument: F1
  24. Moreau D.W., Atakisi H., and Thorne R.E. "Solvent flows, conformation changes and lattice reordering in a cold protein crystal." IUCrJ, D, 75, 11, Pages 980-994, 2019. doi: 10.1107/S2059798319013822. Instrument: F1
  25. Muok A.R., Deng Y., Gumerov V.M., Chong J.E. DeRosa J.R., Kurniyati K., Coleman R.E., Lancaster K.M., Li C., Zhulin I.B., and Crane B.R. "A di-iron protein recruited as an Fe[II] and oxygen sensor for bacterial chemotaxis functions by stabilizing an iron-peroxy species". PNAS, 116 (30), 14955-14960, 2019, doi: 10.1073/pnas.1904234116. Instrument: F1
  26. Noell K.R., Loh J.Y., Debler E.W., Loftus K.M., Cui H., Russ B.B., Zhang K., Goyal P., Solmaz S.R. "Role of Coiled-Coil Registry Shifts in the Activation of Human Bicaudal D2 for Dynein Recruitment upon Cargo Binding".J. Phys Chem Lett., 10, 4362-4367, 2019. doi: 10.1021/acs.jpclett.9b01865. Instrument: F1.
  27. Prakash D., Iyer P.R., Suharti S., Walters K.A., Santiago-MartinezM.G.,Golbeck J.H., Murakami K.S., and Ferry J.G. "Structure and function of an unusual flavodoxin from the domain Archaea". PNAS, 116 (51), 25917-25922, 2019. DOI: 10.1073/pnas.1908578116 Instrument: F1.
  28. Ranaivoson F.M., Turk L.S., Ozgul S., Kakehi S., von Daake S., Lopez N., Trobiani L., De Jaco A., Denissova N., Demeler B., Ozkan E., Montelione G.T., Comoletti D.  "A Proteomic Screen of Neuronal Cell-Surface Molecules Reveals IgLONs as Structurally Conserved Interaction Modules at the Synapse”, STRUCTURE, 27, 6, 893, 2019. doi: 10.1016/j.str.2019.03.004, Instrument: F1; G1
  29. Rose H.R., Maggiolo A.O., McBride M.J., Palowitch G.M., Pandelia M-R., Davis K.M., Yennawar N.H., and Boal A.K. "Structures of Class Id Ribonucleotide Reductase Catalytic Subunits Reveal a Minimal Architecture for Deoxynucleotide Biosynthesis." Biochemistry, 58, 14, 1845–1860, 2019. doi: 10.1021/acs.biochem.8b01252.  Instrument: G1
  30. Sagong H.Y., Bauman J.D., Nogales A., Martínez‐Sobrido L., Arnold E., LaVoie E.J. "Aryl and Arylalkyl Substituted 3‐Hydroxypyridin‐2(1H)‐ones: Synthesis and Evaluation as Inhibitors of Influenza A Endonuclease". ChemMedChem., 14, 1204-1223, 2019. doi: 10.1002/cmdc.201900084. Instrument: F1
  31. Schiltz, CJ (Schiltz, Carl J.); Lee, A (Lee, April); Partlow, EA (Partlow, Edward A.); Hosford, CJ (Hosford, Christopher J.); Chappie, JS (Chappie, Joshua S.); Structural characterization of Class 2 OLD family nucleases supports a two-metal catalysis mechanism for cleavage; NUCLEIC ACIDS RESEARCH (47), 17, 9448-9463 (2019); DOI: 10.1093/nar/gkz703; Instrument: F1.
  32. Smith M.A., Majer S.H., Vilbert A.C., and Lancaster K.M. "Controlling a burn: outer-sphere gating of hydroxylamine oxidation by a distal base in cytochrome P460". Chem Sci.,  10, 3756-3764, 2019. doi: 10.1039/C9SC00195F Instrument: F1
  33. Thomas W.C.,  Brooks F.P. III, Burnim A.A, Bacik J.P.,  Stubbe J., Kaelber J.T., Chen J.Z., Ando N. " Convergent Allostery in Ribonucleotide Reductase". Nature Commun. 10, 2653, 2019. doi: 10.1038/s41467-019-10568-4. Instrument: G1
  34. Tinoco A., Wei Y., Bacik J.P., Carminati D.M., Moore E.J., Ando N., Zhang Y., Fasan R. "Origin of High Stereocontrol in Olefin Cyclopropanation Catalyzed by an Engineered Carbene Transferase". ACS Catal., 9, 1514-1524, 2019. doi: 10.1021/acscatal.8b04073 Instrument: F1.
  35. Travis S.M., Kokona B., Fairman R., and Hughson F.M. "Roles of singleton tryptophan motifs in COPI coat stability and vesicle tethering". PNAS, 116, 48, 24031-24040, 2019. doi: 10.1073/pnas.1909697116. Instrument: F1.
  36. Tubeleviciute-Aydin A., Beautrait A., Lynham J., Sharma G., Gorelik A., Deny L.G., Soya N., Lukacs G.L., Nagar B., Marinier A. & LeBlanc A.C. "Identification of Allosteric Inhibitors against Active Caspase-6". Sci Rep., 9, 5504, 2019 doi: 10.1038/s41598-019-41930-7. Instrument: F1.
  37. Wei Y., Xiong Z.J., Li J., Zou C., Cairo C.W., Klassen J.S & Privé  G.G. "Crystal structures of human lysosomal EPDR1 reveal homology with the superfamily of bacterial lipoprotein transporters". Commun Biol., 2, 52, 2019. doi: 10.1038/s42003-018-0262-9. Instrument: A1
  38. Wierman J.,  Pare-Labrosse O.,  Sarracini A.,  Besaw J., Cook M.,  Oghbaey S.,  Daoud H.,  Mehrabi P.,  Kriksunov I.,  Kuo A.,  Schuller D., Smith S., Ernst O., Szebenyi D.,  Gruner S., Miller D. and Finke A. "Fixed-Target Serial Oscillation Crystallography at Room Temperature." IUCrJ, 6, 2, 305-316, 2019. doi: 10.1107/S2052252519001453. Instrument: G3
  39. Wojnarowicz P.M., Lima E., Silva R., Ohnaka M., Lee S.B., Chin Y., Kulukian A., Chang S.H., Desai B., Garcia Escolano M., Shah R., Garcia-Cao M., Xu S., Kadam R., Goldgur Y., Miller M.A., Ouerfelli O., Yang G., Arakawa T., Albanese S.K., Garland W.A., Stoller G., Chaudhary J., Norton L., Soni R.K., Philip J., Hendrickson R.C., Iavarone A., Dannenberg A.J., Chodera J.D., Pavletich N., Lasorella A., Campochiaro P.A., Benezra R. “A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization”. Cell Rep. 29, 62-75, e7, 2019. doi: 10.1016/j.celrep.2019.08.073. 
  40. Yee E.F., Dzikovski B., Crane B.R. "Tuning Radical Relay Residues by Proton Management Rescues Protein Electron Hopping." JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 141, 44, 17571-17587, 2019. doi: 10.1021/jacs.9b05715; Instrument: F1
  41. Xie Q., Zhao A., Jeffrey F.D., Kim M.K., Bassler B.L., Stone H.A., Novick R.P., Muir T.W. "Identification of a Molecular Latch that Regulates Staphylococcal Virulence". Cell Chem Biol., 26, 548-558, 2019. doi: 10.1016/j.chembiol.2019.01.006. Instrument: F1.

Thesis: 

  1. AlMishwat M.A. (2019). Structural and Mechanistic Enzymology of Nucleotide Incorporation by A-Family DNA Polymerases. Ph.D. The Pennsylvania State University. Instrument: A1, F1
  2. Hillpot E.C. (2019). The 2.8 Å Crystal Structure of a Constitutively Active Alpha Transducin Subunit. M.S. Cornell University. 
  3. Picciano A. (2019). The biochemistry and structure of a novel nitric oxide synthase from cyanobacteria. Ph.D. Cornell University. Instrument: F1
  4. Pillar V.D. (2019). Experimental Characteristics of Diffuse X-Ray Scattering in Lysozyme Crystals. Ph.D. Cornell University. Instrument: F1
  5. Shek R. (2019). Structural and Biochemical Studies of C. jejuni Agmatine Deiminase, E. coli Guanine Deaminase, and S. cerevisiae Guanine Deaminase. Ph.D. State University of New York at Stony Brook. Instrument: A1
  6. Xiong Z-J. (2019). Structural Investigations of Saposin/Hydrolase Systems. Ph.D. University of Toronto (Canada). Instrument: A1

2018

 

  1. Akturk A., Wasilko DJ., Wu X., Liu Y., Zhang Y., Qiu J., Luo Z-Q., Reiter KH., Brzovic PS., Klevit RE., Mao Y. "Mechanism of phosphoribosyl-ubiquitination mediated by a single Legionella effector". Nature, (557)7707, 729, 2018. doi: 10.1038/s41586-018-0147-6. Instrument: F1; A1.
  2. Atakisi H., Moreau D.W,. Thorne R.E. "Effects of protein-crystal hydration and temperature on side-chain conformational heterogeneity in monoclinic lysozyme crystals."Acta Crystallogr. D. Struct .Biol., 264-278, 2018. doi: 10.1107/S2059798318000207. Instrument: F1
  3. Bhatt A., Mondal U.K., Supuran C.T., Ilies M.A., McKenna R. "Crystal Structure of Carbonic Anhydrase II in Complex with an ActivatingLigand: Implications in Neuronal Function." Mol. Neurobiology, 55:7431–7437, 2018. doi: 10.1007/s12035-017-0854-2. Instrument: F1.
  4. Boyer P.L., Smith S.J., Zhao X.Z., Das K., Gruber K., Arnold E., Burke T.R. Jr., Hughes S.H. "Developing and Evaluating Inhibitors against the RNase H Active Site of HIV-1 Reverse Transcriptase." J. Virol., 92,13, 2018. doi: 10.1128/JVI.02203-17. Instrument:F1
  5. Brown J.S., Mohamed Z.J., Artim C.M.,Thornlow D.N., Hassler J.F., Rigoglioso V.P., Daniel S., & Alabi C.A. "Antibacterial isoamphipathic oligomers highlight the importance of multimeric lipid aggregation for antibacterial potency". Commun Biol, 1, 220, 2018. doi: 10.1038/s42003-018-0230-4. Instrument: G1
  6. Bruhn-Olszewska B., Molodtsov V., Sobala M., Dylewski M., Murakami KS., Cashel M., Potrykus K. "Structure-function comparisons of (p)ppApp vs (p)ppGpp for Escherichia coli RNA polymerase binding sites and for rrnB P1 promoter regulatory responses in vitro". Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 1861, 8, 731-742, 2018. doi: 10.1016/j.bbagrm.2018.07.005. Instrument: F1
  7. Casu B., Mary C., Sverzhinsky A., Fouillen A., Nanci A., Baron C. "VirB8 homolog TraE from plasmid pKM101 forms a hexameric ring structure and interacts with the VirB6 homolog TraD", PNAS, 115, 23, 5950-5955, 2018. doi: 10.1073/pnas.1802501115. Instrument: G1
  8. Chen Y-L., Sutton J.L., and Pollack L. "How the Conformations of an Internal Junction Contribute to Fold an RNA Domain." J. Phys. Chem., 122, 49, 11363–11372, 2018. doi: 10.1021/acs.jpcb.8b07262. Instrument: G1
  9. Chen Y.S., Kozlov G., Fakih R., Funato Y., Miki H., Gehring K. "The cyclic nucleotide-binding homology domain of the integral membrane protein CNNM mediates dimerization and is required for Mg2+ efflux activity." J. Biol. Chem., 293(52):19998-20007, 2018. doi 10.1074/jbc.RA118.005672. Instrument: A1
  10. Dupuy FG., Pagano I., Andenoro K., Peralta MF., Elhady Y., Heinrich F., Tristram-Nagle S. "Selective Interaction of Colistin with Lipid Model Membranes". B.J., 114,4, 919-928, 2018. doi: 10.1016/j.bpj.2018.11.020. Instrument: G1
  11. Goffin E., Drapier T., Larsen AP., Geubelle P., Ptak CP., Laulumaa S., Rovinskaja K., Gilissen J., De Tullio P., Olsen L., Frydenvang K., Pirotte B., Hanson J., Oswald RE., Kastrup JS., Francotte P. "7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency". J. Med. Chem., 61, 1, 251-264, 2018. doi: 10.1021/acs.jmedchem.7b01323. Instrument: G1
  12. Gorelik A., Illes K., and Nagar B. "Crystal structure of the mammalian lipopolysaccharide detoxifier". PNAS, USA, 115 5, E896-E905, 2018. doi: 10.1073/pnas.1719834115. Instrument: G1
  13. Greer-Phillips S.E., Sukomon N., Chua T.K., Johnson M.S., Crane B.R., Watts K.J. "The Aer2 receptor from Vibrio cholerae is a dual PAS‐heme oxygen sensor." Mol Microbiol., 109, 2, 2018. doi: 10.1111/mmi.13978. Instrument: A1
  14. Huang Q., Stalnecker C., Zhang C., McDermott LA., Iyer P., O'Neill J., Reimer S., Cerione RA., and Katt WP. "Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism." J Biol Chem. 9;293(10):3535-3545, 2018. doi: https://doi.org/10.1074/jbc.M117.810101. Instrument: A1
  15. Jenkins K.A., Fossat M.J., Zhang S., Rai D.K., Klein S., Gillilan R., White Z., Gerlich G., McCallum S.A., Winter R., Gruner S.M., Barrick D., and Royer K.A. "The consequences of cavity creation on the folding landscape of a repeat protein depend upon context". PNAS. 115,  8153-8161, 2018. doi: 10.1073/pnas.1807379115. Instrument: G1
  16. Koenigsberg A.L., Heldwein E.E. "The dynamic nature of the conserved tegument protein UL37 of herpesviruses." PROTEIN STRUCTURE AND FOLDING, 293, 41, 15827-15839, 2018. doi: 10.1074/jbc.RA118.004481. Instrument: G1
  17. Kim J.K., Lomelino C.L., Avvaru B.S., Mahon B.P., McKenna R., Park S.Y., Kim C.U. "Active-site solvent replenishment observed during human carbonic anhydrase II catalysis". IUCRJ, 5, 93, 102, 2018. doi:10.1107/S2052252517017626. Instrument: F1
  18. Kozlov G.,Wong K.,Wang W., Skubák P., Muñoz-Escobar J., Liu Y., Siddiqui N.,Pannu NS., Gehring K. "Ankyrin repeats as a dimerization module." Biochemical and Biophysical Research Communications, 495, 1, 1002-1007, 2018. doi: 10.1016/j.bbrc.2017.11.135. Instrument: A1
  19. Kozlov G.,  Wong K., Gehring K. "Crystal structure of the Legionella effector Lem22". Proteins, 86, 263-267, 2018. doi: 10.1002/prot.25427. Instrument: F1
  20. Lan T.Y., Wierman J.L., Tate M.W., Philipp H.T., Martin-Garcia J.M., Zhu L., Kissick D., Fromme P., Fischetti R.F., Liu W., Elser V., Gruner S.M. "Solving protein structure from sparse serial microcrystal diffraction data at a storage-ring synchrotron source." IUCrJ, 5, 5, 548-558, 2018. doi: 10.1107/S205225251800903X. 
  21. Lee I-G., Olenick M.A., Boczkowska M., Franzini-Armstrong C., Holzbaur E.L.F.,  & Dominguez  R. "A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity." Nat. Commun., 9, 986, 2018. doi:  10.1038/s41467-018-03412-8. Instrument: F1
  22. Lomelino, Carrie L.; Murray, Akilah B.; Supuran, Claudiu T.; McKenna, Robert, "Sweet Binders: Carbonic Anhydrase IX in Complex with Sucralose". ACS MEDICINAL CHEMISTRY LETTERS, 9, 7, 657-661, 2018. doi: 10.1021/acsmedchemlett.8b00100. Instrument: F1
  23. Mahon B.P., Ambadapadi S., Yaron J.R., Lomelino C.L., Pinard M.A., Keinan S., Kurnikov I., Macaulay C., Zhang L., Reeves W., McFadden G., Tibbetts S., McKenna R., and Lucas A.R. "Crystal Structure of Cleaved Serp-1, a Myxomavirus-Derived Immune Modulating Serpin: Structural Design of Serpin Reactive Center Loop Peptides with Improved Therapeutic Function." Biochemistry, 57, 7, 1096–1107, 2018. doi: 10.1021/acs.biochem.7b01171. Instrument: F1
  24. Mauney AW., Tokuda JM., Gloss LM., Gonzalez O., and Pollack L. "Local DNA Sequence Controls Asymmetry of DNA Unwrapping from Nucleosome Core Particles". Biophysical J., 115, 773–781, 2018. doi: 10.1016/j.bpj.2018.07.009. Instrument: G1
  25. Ménade M., Kozlov G., Trempe J-F, Pande H., Shenker S., Wickremasinghe S., Li X., Hojjat H., Dicaire M-J., Brais B., McPherson PS., Wong MJH., . Young JS., and Gehring K. "Structures of ubiquitin-like (Ubl) and Hsp90-like domains of sacsin provide insight into pathological mutations." J. Biol. Chem., 293(33):12832-12842, 2018. doi: 10.1074/jbc.RA118.003939. Instrument A1, F2
  26. Molodtsov V., Sineva E., Zhang L., Huang X., Cashel M., Ades SE., Murakami K.S. "Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA". Molecular Cell, 69, 5, 828-839, 2018. doi: 10.1016/j.molcel.2018.01.035. Instrument: F1
  27. Molodtsov, V., and Murakami, K.S. "Minimalism and functionality: Structural lessons from the heterodimeric N4 bacteriophageRNA polymerase II." J. Biol. Chem., 293, 13616-13625, 2018. doi: 10.1074/jbc.RA118.003447.  Instrument: F1
  28. Mosaei H., Molodtsov V., Kepplinger B., Harbottle J., Moon CW., Jeeves RE., Ceccaroni L., Shin Y., Morton-Laing S., Marrs ECL., Wills C., Clegg W., Yuzenkova Y., Perry JD., Bacon J., Errington J., Allenby NEE., Hall MJ., Zenkin N. "Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis."  Molecular Cell, 72, 2, 263-274, 2018. doi: 10.1016/j.molcel.2018.08.028. Instrument F1
  29. Munawar A., Beelen S., Munawar A., Lescrinier E., Strelkov S.V. "Discovery of Novel Druggable Sites on Zika Virus NS3 Helicase Using X-ray Crystallography-Based Fragment ScreeningInt". J. Mol. Sci., 19, 11, 3664, 2018. doi: 10.3390/ijms19113664. Instrument F1
  30. Murray A.B., Lomelino C.L., Supuran C.T,. McKenna R. "Seriously Sweet": Acesulfame K Exhibits Selective Inhibition Using Alternative Binding Modes in Carbonic Anhydrase Isoforms". J. Med .Chem., 8, 61, 3, 1176-118, 2018. doi: 10.1021/acs.jmedchem.7b01470. Instrument F1
  31. Nocentini A., Ceruso M., Bua S., Lomelino C.L., Andring J.T., McKenna R., Lanzi C., Sgambellone S., Pecori R., Matucci R., Filippi L., Gratteri P., Carta F., Masini E., Selleri S., and Supuran C.T. "Discovery of β-Adrenergic Receptors Blocker– Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy." J. Med. Chem., 2018, 61, 12, 5380–5394, 2018. doi: 10.1021/acs.jmedchem.8b00625. Instrument F1
  32. O'Donnell J.P., Byrnes L.J., Cooley R.B. and Sondermann H. "A hereditary spastic paraplegia–associated atlastin variant exhibits defective allosteric coupling in the catalytic core." J. Biol. Chem., 293, 2, 687–700, 2018. doi: 10.1074/jbc.RA117.000380. Instrument F1.
  33. O’Donnell J.P., Marsh H.M., Sondermann H., and Sevier C.S. "Disrupted Hydrogen-Bond Network and Impaired ATPase Activity in an Hsc70 Cysteine Mutant." Biochemistry, 57, 7, 1073–1086, 2018. doi: 10.1021/acs.biochem.7b01005. Instrument F1
  34. Parker M.J., Maggiolo A.O., Thomas W.C., Kim A., Meisburger S.P., Ando N., Boal A.K., Stubbe J.A. "An endogenous dAMP ligand in Bacillus subtilis class Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP". PNAS, (115)20, E4594-E4603, 2018. doi: 10.1073/pnas.1800356115. Instrument: G1
  35. Peralta M.F., Smith H., Moody D., Tristram-Nagle S., Carrer D.C. "Effect of Anti-Leishmania Drugs on the Structural and Elastic Properties of Ultradeformable Lipid Membranes." J.Phys.Chem., B, 122, 29,  7332-7339, 2018. doi: 10.1021/acs.jpcb.8b04001. Instrument: G1
  36. Rai D.K., Beaucage G., Vogtt K., Ilavsky J., Kammler H.K. "In situ study of aggregate topology during growth of pyrolytic silica". J.Aerosol Science, v 118, 2018, 34-44, 2018. doi: 10.1016/j.jaerosci.2018.01.006. Instrument: G1
  37. Rizzo A.A., Vassel F.M., Chatterjee N., D'Souza S., Li Y.F., Hao B., Hemann M.T., Walker G.C., Korzhnev D.M. “Rev7 dimerization is important for assembly and function of the Rev1/Pol zeta translesion synthesis complex”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 115, 35, EB191-EB200, 2018. doi: 10.1073/pnas.1801149115. Instrument: F1, G1
  38. Samara Y.N., Brennan H.M., McCarthy L., Bollard M.T., Laspina D., Wlodek J.M., Campos S.L., Natarajan R., Gofron K., McSweeney S., Soares A.S., Leroy L. "Using sound pulses to solve the crystal-harvesting bottleneck." Acta Crystallogr D. Struct. Biol., 986-999, 2018. doi: 10.1107/S2059798318011506. Instrument A1.
  39. Schuller D.J., Huang Q.Q., Lukk T. “Crystallographic exploration of flexibility in an allosteric enzyme”, ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, (74), 0, A68-A68, 2018, DOI: 10.1107/S0108767318099312. Instrument: Facility.
  40. Smith T. J., Font M.E., Kelly C.M., Sondermann H., O'Toole G.A. "An N-Terminal Retention Module Anchors the Giant Adhesin LapA of Pseudomonas fluorescens at the Cell Surface: a Novel Subfamily of Type I Secretion Systems." JOURNAL OF BACTERIOLOGY, 200, 8, e00734-17, 2018. doi: 10.1128/JB.00734-17. Instrument: G1
  41. Szebenyi DM., Kriksunov I., Howe KJ., Ramsey JS,. Hall DG., Heck ML., Krasnoff SB. "Crystal structure of diaphorin methanol monosolvate isolated from Diaphorina citri Kuwayama, the insect vector of citrus greening disease". Acta Crystallographica, E. 74, 4, 445-449, 2018. doi: 10.1107/S2056989018002992. Instrument: F1
  42. Wang C., Lin Y., Bougie D., Gillilan R.E. "Predicting data quality in biological X-ray solution scattering". Acta Crystallographica, D, 74, 727-738, 2018. doi: 10.1107/S2059798318005004. Instrument: G1
  43. Wasilko D.J., Huang Q., Mao Y., "Insights into the ubiquitin transfer cascade catalyzed by the Legionella effector SidC". eLIFE. 7, 2018.  doi: 10.7554/eLife.36154 Instrument: A1
  44. Welty R., Pabit S.A ., Katz A.M., Calvey G.D., Pollack L., Hall K.B. “Divalent ions tune the kinetics of a bacterial GTPase center rRNA folding transition from secondary to tertiary structure”, RNA, 24, 12, 1828-1838, 2018. doi: 10.1261/rna.068361.118. Instrument: G1
  45. Xiao y., He X., Ojeda-Lassalle Y., Poovaiah C. & Coleman H.D. "Expression of a hyperthermophilic endoglucanase in hybrid poplar modifies the plant cell wall and enhances digestibility."  Biotechnol Biofuels, 11, 225, 2018. doi: 10.1186/s13068-018-1224-7
  46. Xu J., Kozlov G., McPherson PS., and Gehring K. "A PH-like domain of the Rab12 guanine nucleotide exchange factor DENND3 binds actin and is required for autophagy". J Biol Chem., 293(12): 4566–4574, 2018. doi: 10.1074/jbc.RA117.001446. Instrument A1.
  47. Yamagami R., Bingaman J.L., Frankel E.A. & Bevilacqua P.C. "Cellular conditions of weakly chelated magnesium ions strongly promote RNA stability and catalysis." Nat. Commun., 9, 2149, 2018. doi: 10.1038/s41467-018-04415-1. Instrument: G1

Thesis: 

  1. Lan T-Y. (2018). Orientation Reconstruction Algorithms for X-Ray Serial Diffraction Data. Ph.D. Cornell University. Instrument: CHESS
  2. Leamy K.A. (2018). INVESTIGATING RNA FOLDING AND ADAPTATION IN CELLULAR CONDITIONS. Ph.D. Penn State. Instrument: G1
  3. Li Y.S. (2018). Allosteric Regulation of the Cancer Associated Mitochondrial Glutaminase GAC. Ph.D. Cornell University. Instrument: A1, F1
  4. Lomelino C. (2018). Structure-Guided Design of Carbonic Anhydrase IX Selective Inhibitors as a Breast Cancer Treatment. Ph.D. University of Florida. Instrument: F1
  5. Smith M.A. (2018). Structural, Spectroscopic, and Mechanistic Insights into the Three Phases of Nitrification Metallobiochemistry. Ph.D. Cornell University. Instrument: F1
  6. Wasilko D.J. (2018). Structural and Biochemical Characterization of Unconventional Bacterial Ubiquitination. Ph.D. Cornell University. Instrument: A1, F1
  7. Wong K. (2028). Manipulation of Host Ubiquitination by the Intracellular Pathogen, Legionella pneumophila. Ph.D. McGill University (Canada). Instrument: A1, F1
  8. Zhou W. (2018). Structural, Functional Characterization and Small Molecule Inhibitors Identification of a Suppressor Negatively Regulating T Cell Signaling Pathway. Ph.D. State University of New York at Stony Brook. Instrument: A1

2017

  1. Alamo L, Koubassova N, Pinto A, Gillilan R, Tsaturyan A, Padrón R, “Lessons from a tarantula: new insights into muscle thick filament and myosin interacting-heads motif structure and function.,” BIOPHYSICAL REVIEWS, SEP 04 2017 Instrument: G1
  2. Alamo L., Ware J.S., Pinto A., Gillilan R.E., Seidman J.G., Seidman C.E., Padrón R. "Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes," Elife eLife 2017;6:e24634, 2017.
  3. Beyersdorf M.S.; Sircar R., Lookadoo D.B., Bottone C J., Lynch M.J., Crane B.R.,  Halkides C.J. “Production, characterization, and assessment of a stable analog of the response regulator CheY-phosphate from Thermotoga maritima.” Protein Science, (26)8, 1547-1554, 2017. Instrument: A1. doio:10.1002/pro.3180
  4. Bhatt A., Mahon B.P., Cruzeiro V.W., Cornelio B., Laronze-Cochard M., Ceruso M., Sapi J., Rance G., Khlobystov A.N., Fontana A., Roitberg A., Supuran C.T., McKenna R. "Structure-Activity Relationships of Benzenesulfonamide-Based Inhibitors towards Carbonic Anhydrase Isoform Specificity," Chem Bio Chem 18(2), 213-222, 2017.
  5. Bingaman J.L., Zhang S., Stevens D.R., Yennawar N.H., Hammes-Schiffer S., Bevilacqua P.C., "The GlcN6P cofactor plays multiple catalytic roles in the glmS ribozyme," Nature Chemical Biology 13(4), 439-445, 2017.
  6. Cadoni R., Pala N, Lomelino C., Mahon BP., McKenna R., Dallocchio R., Dessì A., Carcelli M., Rogolino D., Sanna V., Rassu M., Iaccarino C., Vullo D., Supuran  CT.,  and Sechi M. "Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors." ACS Med. Chem. Lett., 8 (9), 941–946, 2017.
  7. Casu B., Arya T., Bessette B. and Baron C. "Fragment-based screening identifies novel targets for inhibitors of conjugative transfer of antimicrobial resistance by plasmid pKM101." Scientific Reports, v 7, Article number: 14907, 2017.
  8. Comandur R., Olson E.D. and Musier-Forsyth K. "Conservation of tRNA mimicry in the 5'-untranslated region of distinct HIV-1 subtypes". Published by Cold Spring Harbor Laboratory Press for the RNA Society, RNA, 2017. Instrument: G1
  9. Das K., Martinez SE., Arnold E. "Structural Insights into HIV Reverse Transcriptase Mutations Q151M and Q151M Complex That Confer Multinucleoside Drug Resistance". Antimicrobial Agents and Chemotherapy, v 61 Issue 6 e00224-17,  2017.
  10. Davis K.M., Schramma K.R., Hansen W.A., Bacik J.P., Khare S.D. Seyedsayamdost, Mohammad R.; Ando, Nozomi, “Structures of the peptide-modifying radical SAM enzyme SuiB elucidate the basis of substrate recognition." PNAS USA, (114)39, 10420-10425, doi:10.1073/pnas.1703663114, 2017.  Instrument: A1
  11. Fenwick MK, Almabruk KH, Ealick SE, Begley TP, Philmus B, “Biochemical Characterization and Structural Basis of Reactivity and Regioselectivity Differences between Burkholderia thailandensis and Burkholderia glumae 1,6 Didesmethyltoxoflavin N-Methyltransferase,” Biochemistry, 56, 30, 3934-3944, 2017. Instrument: A1, F1. DOI: 10.1021/acs.biochem.7b00476
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  18. Hopkins J.B., Gillilan R.E., and Skou S. "BioXTAS RAW: improvements to a free open-source program for small-angle X-ray scattering data reduction and analysis." JOURNAL OF APPLIED CRYSTALLOGRAPHY. 50, 5, 1545-1553, 2017. doi: 10.1107/S1600576717011438. Instrument: F2, G1
  19. Hsieh CL, Ptak CP, Tseng A, Suguiura IMS, McDonough SP, Sritrakul T, Li T, Lin YP, Gillilan RE, Oswald RE, Chang YF, “Extended low-resolution structure of a Leptospira antigen offers high bactericidal antibody accessibility amenable to vaccine design.,” ELIFE, DEC 06 2017 Instrument: G1
  20. Jayanthi S, Koppolu B.P., Nguyen K.G., mith S.G., Felber B.K., Kumar T.K.S.& Zaharoff D.A. "Modulation of Interleukin-12 activity in the presence of heparin". Scientific Reports 7, Article number: 5360 doi:10.1038/s41598-017-05382-1, 2017.
  21. Lan TY, Wierman JL, Tate MW, Philipp HT, Elser V, Gruner SM, "Reconstructing three-dimensional protein crystal intensities from sparse unoriented two-axis X-ray diffraction patterns", Journal of Applied Crystallography 50(4), 985-993 (2017).
  22. Leamy K.A., Yennawar N.H., and Bevilacqua P.C. "Cooperative RNA Folding under Cellular Conditions Arises From Both Tertiary Structure Stabilization and Secondary Structure Destabilization". Biochemistry, 2017, 56 (27), 3422–3433, DOI: 10.1021/acs.biochem.7b00325, 2017.
  23. Lemon D.J., Yang X., Srivastava P., Luk Y-Y. & Garza A.G."Polymertropism of rod-shaped bacteria: movement along aligned polysaccharide fibers". Scientific Reports 7, Article number: 7643, doi:10.1038/s41598-017-07486-0, 2017.
  24. Lynch M.J., Levenson R., Kim E.A., Sircar R., Blair D.F., Dahlquist F.W., Crane B.R. "Co-Folding of a FliF-FliG Split Domain Forms the Basis of the MS:C Ring Interface within the Bacterial Flagellar MotorOriginal". Structure, v. 25, (2), 317-328, 2017.
  25. Maffioli SA. Zhang Y., Degen D., Carzaniga T. Del Gatto G., Serina S., Monciardini P,. Mazzetti C., Guglierame P., Candiani G., Chiriac A.I., Facchetti G., Kaltofen P., Sah H-G., Dehò G., Donadio S., Ebright R.H. "Antibacterial "Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase". Cell, V. 169, Issue 7, 1240-1248, e23, 2017.
  26. Malhotra K., Modak A., Nangia S., Daman T.H., Gunse U., Robinson V.L., Mokranjac D., May E.R. and Alder N.N. "Cardiolipin mediates membrane and channel interactions of the mitochondrial TIM23 protein import complex receptor Tim50". Science Advances, Vol. 3, no. 9, e1700532, DOI: 10.1126/sciadv.1700532, 2017.
  27. Mboge M.Y., Mahon B.P., Lamas N., Socorro L., Carta F., Supuran C.T., Frost S.C., McKenna R. "Structure activity study of carbonic anhydrase IX: Selective inhibition with ureido-substituted benzenesulfonamides". European Journal of Medicinal Chemistry, v. 132, 184-191, 2017.
  28. Meisburger S.P., Ando N., "Correlated Motions from Crystallography beyond Diffraction," Accounts of Chemical Research 50(3), 580-583, 2017.
  29. Mizrachi, Dario; Robinson, Michael-Paul; Ren, Guoping; Ke, Na; Berkmen, Mehmet; DeLisa, Matthew P. "A water-soluble DsbB variant that catalyzes disulfide-bond formation in vivo". Nature Chemical Biology, 13, 1022–1028, doi:10.1038/NCHEMBIO.2409, 2017. Instrument: G1
  30. Molodtsov, V., Scharf, N.T., Stefan, M.A., Garcia, G.A. and Murakami, K.S. "Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis". Molecular Microbiology. doi:10.1111/mmi.13606, 2017.
  31. Muñoz-Escobar J., Matta-Camacho E., Cho C, Kozlov G., Gehring K. "Bound Waters Mediate Binding of Diverse Substrates to a Ubiquitin Ligase". Structure, v. 25, 5, 719–729, e3. 2017.
  32. Murakami K.S., Shin, Y., Turnbough C.L., Jr., and Molodtsov V. "X-ray crystal structure of a reiterative transcription complex reveals an atypical RNA extension pathway." PNAS U S A 114, 8211-8216, 2017
  33. Nguyen K., Li J., Puthenveeti R., Lin X., Poe M.M., Hsiao C-H.C., Vinogradova O. and Wiemer A.J. "The butyrophilin 3A1 intracellular domain undergoes a conformational change involving the juxtamembrane region". FASEB J., doi: 10.1096/fj.201601370RR, 2017.
  34. Nocentini A., Bua S., Lomelino CL., McKenna R., Menicatti M., Bartolucci G., Tenci B., Mannelli LDC., Ghelardini C., Gratteri P., and Supuran CT. "Discovery of New Sulfonamide Carbonic Anhydrase IX Inhibitors Incorporating Nitrogenous Bases". ACSMed.Chem.Lett., 8, 1314−1319, 2017.
  35. O'Donnell JP., Cooley R.B., Kelly C.M., Miller K., Sondermann H. "Timing and Reset Mechanism of GTP Hydrolysis-Driven Conformational Changes of Atlastin Original research article." Structure, In press, Available online 9 June 2017
  36. Oudouhou F., Casu B., Puemi A.S.D., Sygusch J., Baron C., "Analysis of Novel Interactions between Components of the Selenocysteine Biosynthesis Pathway, SEPHS1, SEPHS2, SEPSECS, and SECp43," Biochemistry 56(17), 2261-2270, 2017.
  37. Park W.M., Bedewy M., Berggren K.K. & Keating A.E. "Modular assembly of a protein nanotriangle using orthogonally interacting coiled coils". Scientific Reports 7, Article number: 10577 doi:10.1038/s41598-017-10918-6, 2017.
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  39. Plumridge A, Meisburger S.P, Andresen K, Pollack L, "The impact of base stacking on the conformations and electrostatics of single-stranded DNA," Nucleic Acids Research 45(7), 3932-3943 2017.
  40. Plumridge A., Meisburger S.P., Pollack L., "Visualizing single-stranded nucleic acids in solution," Nucleic Acids Research 45(9), 2017.
  41. Portz B., Lu F., Gibbs E.B., Mayfield J.E., Mehaffey M.R., Zhang Y.J., Brodbelt J.S., Showalter S.A. & Gilmour D.S. "Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain". Nature Communications 8, Article number: 15231, doi:10.1038/ncomms15231, 2017.
  42. Pudasaini A., Shim J.S., Song Y.H., Shi H., Kiba T., Somers D.E., Imaizumi T., and Zoltowski B.D. "Kinetics of the LOV domain of ZEITLUPE determine its circadian function in Arabidopsis". eLife, 6: e21646. 2017.
  43. Roig-Solvas B., Makowski L. "Calculation of the cross-sectional shape of a fibril from equatorial scattering". Ths paper is written in celebration of the occasion of Donald L.D. Caspar’s 90th Birthday. Journal of Structural Biology, 2017.
  44. Sankhala RS, Lokareddy RK, Begum S, Pumroy RA, Gillilan RE, Cingolani G, “Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1,” NATURE COMMUNICATIONS, OCT 17 2017. Instrument: G1.
  45. Shek R., Dattmore DA., Stives DP., Jackson AL., Chatfield CH., Hicks KA., French JB. "Structural and Functional Basis for Targeting Campylobacter jejuni Agmatine Deiminase To Overcome Antibiotic Resistance." Biochemistry. 56(51):6734-6742, 2017.
  46. Tian D., Battles MB., Moin SM., Chen M., Modjarrad K., Kumar A., Kanekiyo M., Graepel KW., Taher NM., Hotard AL., Moore ML., Zhao M., Zheng Z-Z., Xia N-S., McLellan JS. and Graham BS. "Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein". Nature Communications, v 8, Article number: 1877, 2017.
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  50. Xiao, Yibei; Ng, Sherwin; Nam, Ki Hyun; Ke, Ailong. "How type II CRISPR-Cas establish immunity through Cas1-Cas2-mediated spacer integration". Nature, 550,137–141, DOI:
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  51. Zhang H., Kozlov G., Li X., Wu H., Gulerez I. & Gehring K. "PRL3 phosphatase active site is required for binding the putative magnesium transporter CNNM3". Scientific Reports 7, Article number: 48, doi:10.1038/s41598-017-00147-2, 2017.

Ph.D. Theses

  1. Wierman, J.L. "Exploration of Methods for Serial Microcrystallography at Storage Ring X-ray Sources" Ph.D. Thesis, Cornell University, Adviser: Sol M. Gruner (2017)

2016

  1. Alamo L, Qi D, Wriggers W, Antonio, Zhu J, Bilbao A, Gillilan RE, Hu S, Padron R. "Conserved intramolecular interactions maintain myosin interacting-heads motifs explaining tarantula muscle super-relaxed state structural basis." Journal of Molecular Biology (2016).
  2. Ando N, Li H, Brignole EJ, Thompson S, McLaughlin MI, Page JE, Asturias FJ, Stubbe J, and Drennan CL. "Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer". Biochemistry, 55 (2), pp 373–381, (2016).
  3. Bauman JD, Harrison JJEK, Arnold E. "Rapid experimental SAD phasing and hot-spot identification with halogenated fragments." IUCrJ 3(1), 51-60 (2016).
  4. Bhambure R, Gillespie CM, Phillips M, Graalfs H, Lenhoff AM. "Ionic strength-dependent changes in tentacular ion exchangers with variable ligand density. I. Structural properties". Journal of Chromatography A, Volume 1463, 9 September 2016, Pages 90-101, ISSN 0021-9673, (2016).
  5. Bhatt, A., Mahon, B. P., Cruzeiro, V. W. D., Cornelio, B., Laronze-Cochard, M., Ceruso, M., Sapi, J., Rance, G. A., Khlobystov, A. N., Fontana, A., Roitberg, A., Supuran, C. T. and McKenna, R. "Structure–Activity Relationships of Benzenesulfonamide-Based Inhibitors towards Carbonic Anhydrase Isoform Specificity". ChemBioChem. doi:10.1002/cbic.201600513 (2016).
  6. Bhardwaj A, Sankhala RS, Olia AS, Brooke D, Casjens SR, Taylor DJ, Prevelige PE Jr, Cingolani G. "Structural Plasticity of the Protein Plug That Traps Newly Packaged Genomes in Podoviridae Virions." The Journal of Biological Chemistry 291, 215-226 (2016).
  7. Boyaci H, Shah T, Hurley A, Kokona B, Li Z, Ventocilla C, Jeffrey PD, Semmelhack MF, Fairman R, Bassler BL, Hughson FM. "Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO". PLOC, (2016).
  8. Branchini BR., Southworth TL., Fontaine DM., Murtiashaw MH., McGurk A., Talukder MH., Qureshi R., Yetil D., Sundlov JA. and  Gulick AM.  "Cloning of the Orange Light-Producing Luciferase from Photinus scintillans". Photochemistry and Photobiology, 93: 479–485, 2017.
  9. Cho S, Dickey SW, Urban S. "Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis." Molecular Cell 61(3), 329-340 (2016).
  10. Conrad KS, Hurley JM, Widom J, Ringelberg CS, Loros JJ, Dunlap JC, Crane BR. "Structure of the frequency-interacting RNA helicase: a protein interaction hub for the circadian clock". EMBO Journal, 35, 1707-1719,(2016)
  11. Cooley RB, O’Donnell JP and Sondermann H. “Coincidence detection and bi-directional transmembrane signaling control a bacterial second messenger receptor.” eLife 2016;5:e21848, (2016).
  12. Corcos AR, Villanueva O, Walroth RC, Sharma SK, Bacsa J, Lancaster KM, MacBeth CE, Berry JF, "Oxygen Activation by Co(II) and a Redox Non-Innocent Ligand: Spectroscopic Characterization of a Radical–Co(II)–Superoxide Complex with Divergent Catalytic Reactivity," Journal of the American Chemical Society 138(6), 1796-1799 (2016).
  13. Dahlstrom KM, Giglio KM, Sondermann H and O'Toole GA "The Inhibitory Site of a Diguanylate Cyclase Is a Necessary Element for Interaction and Signaling with an Effector Protein". J. Bacteriol. v. 198 no. 11, 1595-1603, (2016).
  14. Das K, Balzarini J, Miller MT, Maguire AR, DeStefano JJ, and Arnold E. "Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis—Binding of Foscarnet". ACS Chem. Biol. (2016).
  15. Devarkar SC, Wang C, Miller MT, Ramanathan A, Jiang F, Khan AG, Patel SS, and Marcotrigiano J. "Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I". PNAS, vol. 113 no. 3 pp. 596–601, (2016).
  16. Eisemann T, McCauley M, Langelier M-F, Gupta K, Roy S, Van Duyne GD, Pascal JM. "Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification". Structure, 24, 1–14, (2016).
  17. Ericson DL, Yin X, Scalia A, Samara YN, Stearns R, Vlahos H, Ellson R, Sweet RM, Soares AS. "Acoustic Methods to Monitor Protein Crystallization and to Detect Protein Crystals in Suspensions of Agarose and Lipidic Cubic Phase". Journal of Laboratory Automation, v. 21 no. 1, pp. 107-114, (2016).
  18. Fenwick MK, Philmus B, Begley TP, and Ealick SE. "Burkholderia glumae ToxA Is a Dual-Specificity Methyltransferase That Catalyzes the Last Two Steps of Toxoflavin Biosynthesis". Biochemistry, 55 (19), pp 2748–2759, (2016).
  19. Fenwick MK and Ealick SE. "Crystal Structures of the Iron–Sulfur Cluster-Dependent Quinolinate Synthase in Complex with Dihydroxyacetone Phosphate, Iminoaspartate Analogues, and Quinolinate". Biochemistry, 55 (30), 4135-4139, (2016).
  20. Gibbs EB and Showalter SA. "Quantification of Compactness and Local Order in the Ensemble of the Intrinsically Disordered Protein FCP1". J. Phys. Chem. B, 120 (34), pp 8960–8969, (2016).
  21. Gorelik A, Illes K, Superti-Furga G, Nagar B, "Structural Basis for Nucleotide Hydrolysis by the Acid Sphingomyelinase-Like Phosphodiesterase SMPDL3A," The Journal of Biological Chemistry (2016).
  22. Henderson RC, Gao F, Jayanthi S, Kight A, Sharma P, Goforth RL, Heyes CD, Henry RL, Thallapuranam Krishnaswamy Suresh Kumar. "Domain Organization in the 54-kDa Subunit of the Chloroplast Signal Recognition Particle", Biophysical Journal, Volume 111, Issue 6, 1151-1162, (2016)
  23. Hopkins JB and Thorne RE, "Quantifying radiation damage in biomolecular small-angle X-ray scattering", J Appl Crystallogr, 49(3), 880-890 (2016).
  24. Huang LY, Patel A, Ng R, Miller EB, Halder S, McKenna R, Asokan A, and Agbandje-McKenna M. "Characterization of the Adeno-Associated Virus 1 and 6 Sialic Acid Binding Site". Journal of Virology, (2016)
  25. Huang Q, Gruner SM, Kim CU, Mao Y, Wu X, Szebenyi DM. "Reduction of lattice disorder in protein crystals by high-pressure cryocooling," J Appl Crystallogr. 49(1), 149-157 (2016).
  26. Huang Q, Szebenyi DME, "Improving diffraction resolution using a new dehydration method." Acta Crystallographica Section F 72(2), 152-159 (2016).
  27. Karasawa A., Kawate T. "Structural basis for subtype-specific inhibition of the P2X7 receptor". eLife, 2016.
  28. Kim CU, Song HJ, Avvaru BS, Gruner SM, Park SY, and McKenna R. "Tracking solvent and protein movement during CO2 release in carbonic anhydrase II crystals." PNAS, v. 113 no. 19, pp. 5257–5262, (2016).
  29. Li Y, Erickson JW, Stalnecker CA, Katt WP, Huang Q, Cerione RA, Ramachandran S, "Mechanistic Basis of Glutaminase Activation: A Key Enzyme that Promotes Glutamine Metabolism in Cancer Cells", J Bio Chem (2016).
  30. Lomelino CL, Mahon BP, McKenna R, Carta F, Supuran CT. "Kinetic and X-ray crystallographic investigations on carbonic anhydrase isoforms I, II, IX and XII of a thioureido analog of SLC-0111". Bioorganic & Medicinal Chemistry, v 24, 5, pp. 976–981, (2016).
  31. Lucido MJ, Orlando BJ, Vecchio AJ, Malkowski MG. "Crystal structure of aspirin-acetylated human cyclooxygenase-2: Insight into the formation of products with reversed stereochemistry." Biochemistry including biophysical chemistry and molecular biology 55(8), 1226-1238 (2016).
  32. Lukk T, Gillilan RE, Szebenyi DM, Zipfel WR. "A visible-light-excited fluorescence method for imaging protein crystals without added dyes." J Appl Crystallogr 49, 234-240 (2016).
  33. Mahon BP, Kurian JJ, Lomelino CL, Smith IR, Socorro L, Bennett A, Hendon AM, Chipman P, Savin DA, Agbandje-McKenna M and McKenna R. "Microbatch Mixing: “Shaken not Stirred”, a Method for Macromolecular Microcrystal Production for Serial Crystallography". Crystal Growth & Design, 16 (11), 6214-6221, (2016).
  34. Mahon BP, Bhatt A, Socorro L, Driscoll JM, Okoh C, Lomelino CL, Mboge MY, Kurian JJ, Tu C, Agbandje-McKenna M, Frost SC, and McKenna R. "The Structure of Carbonic Anhydrase IX Is Adapted for Low-pH Catalysis". Biochemistry, 55 (33), 4642-4653 (2016).
  35. Matsuyama BY, Krasteva P, Baraquet C, Harwood CS, Sondermann H, Navarro MVAS. "Mechanistic insights into c-di-GMP–dependent control of the biofilm regulator FleQ from Pseudomonas aeruginosa". PNAS, v. 113, 2, (2016).
  36. McDermott LA , Iyer P, Vernetti L, Rimer S, Sun J, Boby M, Yang T, Fioravanti M, O’Neill J, Wang L, Drakes D, Katt W, Huang Q, Cerione R. "Design and evaluation of novel glutaminase inhibitors." Bioorganic & Medicinal Chemistry (2016).
  37. Meisburger SP, Taylor AB, Khan CA, Zhang S, Fitzpatrick PF, and Ando A. "Domain Movements upon Activation of Phenylalanine Hydroxylase Characterized by Crystallography and Chromatography-Coupled Small-Angle X-ray Scattering". J. Am. Chem. Soc., 138 (20), pp. 6506–6516, (2016).
  38. Miller MT, Tuske S, Das K, DeStefano JJ, Arnold E. "Structure of HIV-1 reverse transcriptase bound to a novel 38-mer hairpin template-primer DNA aptamer." Protein Sci. 25, 46-55 (2016).
  39. Mori S, Simkhada D, Zhang H, Erb MS, Zhang Y, Williams H, Fedoseyenko D, Russell WK, Kim D, Fleer N, Ealick SE, and Watanabe CMH. "Polyketide Ring Expansion Mediated by a Thioesterase, Chain Elongation and Cyclization Domain, in Azinomycin Biosynthesis: Characterization of AziB and AziG". Biochemistry, 55 (4), pp 704–714, (2016).
  40. Oot RA, Kane PM, Berry EA & Wilkens S. "Crystal structure of yeast V1-ATPase in the autoinhibited state". EMBO Journal, 35, 1694-1706, (2016).
  41. Pabit SA, Katz AM, Tolokh AS, Drozdetski A, Baker N, Onufriev AV, and Pollack L. "Understanding nucleic acid structural changes by comparing wide-angle x-ray scattering (WAXS) experiments to molecular dynamics simulations". J. Chem. Phys. 144, 205102 (2016).
  42. Payne T, Yee E, Dzikovski B, Crane B, "Constraints on the Radical Cation Center of Cytochrome c Peroxidase for Electron Transfer from Cytochrome c." Biochemistry 55(34), 4807-4822 (2016).
  43. Patel D, Antwi J, Koneru PC, Serrao E, Forli S, Kessl JJ, Feng L, Deng N, Levy PM, Fuchs JR, Olson AJ, Engelman AN, Bauman JD, Kvaratskhelia M and Arnold E. "A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain". J. Biolog. Chem., v. 291, NO. 45, pp. 23569 –23577, (2016)..
  44. Pinard MA, Kurian J., Aggarwal M, Agbandje-McKenna M. and McKenna R. "Cryoannealing-induced space-group transition of crystals of the carbonic anhydrase psCA3". Acta Crystallographica Section F, Volume 72, Part 7, 573-577 (2016).
  45. Postel S, Deredge D, Bonsor DA, Yu X, Diederichs K. Helmsing S, Vromen A, Friedler A, Hust M, Egelman EH, Beckett D, Wintrode PL, Sundberg EJ. "Bacterial flagellar capping proteins adopt diverse oligomeric states". eLife 2016;5:e18857
  46. Pradhan L, Gopal S, Li S, Ashur S, Suryanarayanan S, Kasahara H, and Nam HJ. "Intermolecular Interactions of Cardiac Transcription Factors NKX2.5 and TBX5". Biochemistry, 55 (12), pp 1702–1710, (2016)
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  48. Richardson BC, Halaby SL, Gustafson MA, Fromme JC. "The Sec7 N-terminal regulatory domains facilitate membrane-proximal activation of the Arf1 GTPase". eLIFE (2016).
  49. Rustiguel, J. K., Soares, R. O. S., Meisburger, S. P., Davis, K. M., Malzbender, K. L., Ando, N., Dias-Baruffi, M., & Nonato, M. C. “Full-length model of the human galectin-4 and insights into dynamics of inter-domain communication” Sci. Rep. 6, 33633. (2016)
  50. Sarowar S, Hu J, Werneburg GT, Thanassi DG, Li H. "The Escherichia coli P and type 1 pilus assembly chaperones PapD and FimC are monomeric in solution". J. Bacteriol., (2016).
  51. Schormann, N., Zhukovskaya, N., Bedwell, G., Nuth, M., Gillilan, R., Prevelige, P. E., Ricciardi, R. P., Banerjee, S. and Chattopadhyay, D. "Poxvirus uracil-DNA glycosylase—An unusual member of the family I uracil-DNA glycosylases." Protein Science, 25: 2113–2131. doi:10.1002/pro.3058, (2016).
  52. Singh G, Zhang J, Ma Y, Cerione RA, Antonyak MA, "The different conformational states of Tissue Transglutaminase have opposing affects on cell viability". The Journal of Biological Chemistry (2016).
  53. Trempe J.-F, Šašková KG, Sivá M, Ratcliffe CDH, Veverka V, Hoegl A, Ménade M, Feng X, Shenker S, Svoboda M, Kožíšek M, Konvalinka J, Gehring K. "Structural studies of the yeast DNA damage-inducible protein Ddi1 reveal domain architecture of this eukaryotic protein family". Sci. Rep. 6, 33671, (2016).
  54. Wierman J, Lan TY, Tate M, Philipp H, Elser V, and Gruner S. "Protein Crystal Structure from Non-oriented, Single-axis Sparse X-ray Data." IUCrJ 3: 43-50 (2016).
  55. Xiong Z-X, Huang J., Poda G., Pomès R., Privé G.G. "Structure of Human Acid Sphingomyelinase Reveals the Role of the Saposin Domain in Activating Substrate Hydrolysis". J. Mol. Biology, In Press, (2016).
  56. Xu C, Kozlov G, Wong K, Gehring K, Cygler M. "Crystal Structure of the Salmonella Typhimurium Effector GtgE". PLoS ONE 11(12): e0166643. doi:10.1371/journal. pone.0166643 (2016).
  57. Zhang H, Chang Y-C,, Huang Q, Brennan ML, Wu J. "Structural and Functional Analysis of a Talin Triple-Domain Module Suggests an Alternative Talin Autoinhibitory Configuration". Structure, v. 24, 5, pp. 721–729, (2016).

Ph.D. Theses

  1. Hopkins J., "Development Of Low Temperature Biological Small Angle X-Ray Scattering, Cryosaxs, And Study Of Ice Formation In Aqueous Solutions" Ph.D. Thesis, Cornell University, Advisor: Robert Thorne, (2016).
  2. Howell SC., "Dynamic Conformations of Nucleosome Arrays in Solution from Small-Angle X-ray Scattering," Ph.D. Thesis, The George Washington University, Advisor: Xiangyun Qiu (2016).

Videos

  1. CLASSE atCornell, "BioSAXS Essentials 6 Workshop, May 2016", YouTube, Web. 24 Aug. 2016.

2015

  1. Acerbo AS, Cook MJ, Gillilan RE, "Upgrade of MacCHESS facility for X-ray scattering of biological macromolecules in solution". J Synchrotron Radiat., PMID: 25537607 22(1), 180-6 (2015)
  2. Aggarwal M, Chua TK, Pinard MA, Szebenyi DM, McKenna R, "Carbon Dioxide "Trapped" in a ß-Carbonic Anhydrase," Biochemistry 54(43), 6631-6638 (2015)
  3. Ayyer K, Philipp HT, Tate MW, . Wierman JL, Elser V and Gruner S M. "Determination of crystallographic intensities from sparse data." IUCrJ 2:29-34 (2015)
  4. Balzarini J, Das K, Bernatchez J, Martinez S, Ngure M, Keane S, Ford A, Maguire N, Mullins N, John J, Kim Y, Dehaen W, Woorde J, Liekens S, Naesens L, Gotte M, Maguire A, Arnold E, "Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics," PNAS 112(11) (2015)
  5. Barnett GV, Razinkov VI, Kerwin BA, Laue TM, Woodka AH, Butler PD, Perevozchikova T, Roberts CJ, "Specific-ion effects on the aggregation mechanisms and protein-protein interactions for anti-streptavidin immunoglobulin gamma-1," J Phys Chem B 119(18), 5793-804 (2015)
  6. Boock JT, King BC, Taw M, Conrado RJ, Siu K-H, Stark J, Walker LP, Gibson DM, DeLisa MP, "Repurposing a bacterial quality control mechanism to enhance production of a fungal endocellulase". Journal of Molecular Biology (2015)
  7. Boone C, Rasi V, McKenna R. "Structural and catalytic effects of proline substitution and surface loop deletion in the extended active site of human carbonic anhydrase II". FEBS Journal, v 282, 8, 1445–1457, (2015)
  8. Carta F, Mannelli LDC, Pinard M, Ghelardini C, Scozzafava A, McKenna R, Supuran CT. "A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects". Bioorganic & Medicinal Chemistry, v 23, 8, 1828–1840, (2015)
  9. Criswell A, Mooers BHM, "Structural studies of a double-stranded RNA from trypanosome RNA editing by small-angle X-ray scattering". Methods Mol Biol. 1240, 165-89 (2015)
  10. Couoh-Cardel S, Milgrom E and Wilkens S. "Affinity Purification and Structural Features of the Yeast Vacuolar ATPase Vo Membrane Sector". The Journal of Biological Chemistry, 290, 27959-27971, (2015)
  11. Freed DM, Alvarado D, & Lemmon MA. "Ligand regulation of a constitutively dimeric EGF receptor". Nature Communications, 6, Article number: 7380, (2015)
  12. Dahlstrom KM, Giglio KM, Collins AJ, Sondermann H, O’Toole GA. "Contribution of Physical Interactions to Signaling Specificity between a Diguanylate Cyclase and Its Effector". mBio vol. 6 no. 6, (2015)
  13. Díaz-Torres NA, Mahon BP, Boone CD, Pinard MA, Tu C, Ng R, Agbandje-McKenna M, Silverman D, Scott K and McKenna R. "Structural and biophysical characterization of the a-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2: insights into engineering thermostable enzymes for CO2 sequestration". Acta Crystallographica Section D, v 71, 8, 1745-1756, (2015)
  14. Garg A, Lukk T, Kumar V, Choi JY, Augagneur Y, Voelker DR, Nair S, Mamoun CB, "Structure, Function and Inhibition of the Phosphoethanolamine Methyltransferases of the Human Malaria Parasites Plasmodium vivax and Plasmodium knowlesi", Scientific Reports 5 (2015).
  15. Gilman MSA, Moin SM, Mas V, Chen M, Patel NK, Kramer K, Zhu Q, Kabeche SC, Kumar A, Palomo C, Beaumont T, Baxa U, Ulbrandt ND, Melero JA, Graham BS, McLellan JS. "Characterization of a Prefusion-Specific Antibody That Recognizes a Quaternary, Cleavage-Dependent Epitope on the RSV Fusion Glycoprotein". PLoS Pathogens Issue, Vol. 11(7), (2015)
  16. Greene DG, Modla S, Wagner NJ, Sandler SI, Lenhoff AM. "Local Crystalline Structure in an Amorphous Protein Dense Phase". Biophysical Journal, v 109, 8, pp 1716–1723, (2015)
  17. Greenswag AR, Muok A, Li X, Crane BR. "Conformational Transitions that Enable Histidine Kinase Autophosphorylation and Receptor Array Integration". Journal of Molecular Biology, v 427, 24, 3890–3907, (2015)
  18. Greenswag AR, Li X, Borbat PP, Samanta D, Watts KJ, Freed JH, and Crane BR. "Preformed Soluble Chemoreceptor Trimers That Mimic Cellular Assembly States and Activate CheA Autophosphorylation". Biochemistry, 54 (22), pp 3454–3468, (2015)
  19. Gruner S, Lattman E, "Biostructural Science Inspired by Next-Generation X-Ray Sources", Annual Rev. Biophysics 44:33-51. (2015)
  20. Guo F, Zhou W, Li P, Mao Z, Yennawar NH, French JB, and Huang TJ. "Precise Manipulation and Patterning of Protein Crystals for Macromolecular Crystallography Using Surface Acoustic Waves". Small, v 11, Issue 23, pp 2733–2737, (2015)
  21. Gupta K, Martin R, Sharp R, Sarachan KL, Ninan NS and Van Duyne GD. "Oligomeric Properties of Survival Motor Neuron·Gemin2 Complexes". The Journal of Biological Chemistry 290, 20185-20199, (2015)
  22. Haldera S, Vlieta KV, Smith JK, Duong TTP, McKenna R, Wilson JM, Agbandje-McKenna M. "Structure of neurotropic adeno-associated virus AAVrh.8". Journal of Structural Biology, v 192, 1, pp 21–36, (2015)
  23. Hauk G, Bowman GD. "Formation of a Trimeric Xpo1-Ran[GTP]-Ded1 Exportin Complex Modulates ATPase and Helicase Activities of Ded1". PLOS, (2015)
  24. Hopkins JB, Katz AM, Meisburger SP, Warkentin MA, Thorne RE, Pollack L, "A microfabricated fixed path length silicon sample holder improves background subtraction for cryoSAXS". Applied Crystallography Online 48(1), 227-237 (2015)
  25. Hsu F, Hu F, Mao Y, "Spatiotemporal control of phosphatidylinositol 4-phosphate by Sac2 regulates endocytic recycling," J Cell Biol 209(1), 97-110 (2015)
  26. Huang Q, Gruner SM, Kim CU, Mao Y , Wu X, and Szebenyi DME. "Reduction of lattice disorder in protein crystals by high pressure cryocooling". J. Appl. Crystallography (In press) (2015)
  27. Keedy D A, Kenner LR, Warkentin M, Woldeyes RA, Hopkins JB, Thompson MC, Brewster AS, Van Benschoten AH, Baxter EL, Uervirojnangkoorn M, McPhillips SE, Song J, Alonso-Mori R, Holton JM, Weis WI, Brunger AT, Soltis SM,Lemke H, Gonzalez A, Sauter NK, Cohen AE, Van den Bedem H, Thorne RE, Fraser JS. "Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography". eLife, 10.7554, (2015)
  28. Kim CU, Tate MW, and Gruner SM. "Glass-to-cryogenic liquid transitions in water solutions examined by crack-healing". Proc. Natl. Acad. Sci. USA 112:11765-11770 (2015)
  29. Kucerka N, Oosten B, Pan J, Heverle F, Harroun T, Katsaras J, "Molecular Structures of Fluid Phosphatidylethanolamine Bilayers Obtained from Simulation-to-Experiment Comparisons and Experimental Scattering Density Profiles," The Journal of Physical Chemistry B 119(5), 1947-1956 (2015)
  30. Kumar AK, Kumar RSS, Yennawar NH, Yennawar HP, and Ferry JG. "Structural and Biochemical Characterization of a Ferredoxin:Thioredoxin Reductase-like Enzyme from Methanosarcina acetivorans". Biochemistry, 54 (19), pp 3122–3128, (2015)
  31. Loh S, Ha J-H, Mitrea D, "Domain Swapping Modules", (2015)
  32. Lokhandwala J, Hopkins HC, Rodriguez-Iglesias A, Dattenböck C, Schmoll M, Zoltowski BD. "Structural Biochemistry of a Fungal LOV Domain Photoreceptor Reveals an Evolutionarily Conserved Pathway Integrating Light and Oxidative Stress". Structure, v 23, 1, 116–125, (2015)
  33. Luo X, Wasilko DJ, Liu Y, Sun J, Wu X, Luo ZQ, Mao Y. "Structure of the Legionella Virulence Factor, SidC Reveals a Unique PI(4)P-Specific Binding Domain Essential for Its Targeting to the Bacterial Phagosome". PLOS, (2015)
  34. Madasu Y, Yang C, Boczkowska M, Bethoney KA, Zwolak A, Rebowski G, Svitkina T, Dominguez R, "PICK1 is implicated in organelle motility in an Arp2/3 complex-independent manner," Mol Biol Cell. 26(7), 1308-22 (2015)
  35. Meisburger SP, Pabit SA, Pollack L, "Determining the Locations of Ions and Water around DNA from X-Ray Scattering Measurements", Biophys J. 108(12), 2886-95 (2015)
  36. Mizrachi D, Chen Y, Liu J, Peng HM, Ke A, Pollack L, Turner RJ, Auchus RJ & DeLisa MP. "Making water-soluble integral membrane proteins in vivo using an amphipathic protein fusion strategy". Nature Communications, 6, Article number:6826, (2015)
  37. Molodtsov V, Fleming PR, Eyermann CJ, Ferguson AD, Foulk MA, McKinney DC, Masse CE, Buurman ET, Murakami KS, "X-ray crystal structures of Escherichia coli RNA polymerase with switch region binding inhibitors enable rational design of squaramides with an improved fraction unbound to human plasma protein," J Med Chem 58(7), 3156-71 (2015)
  38. Moravcevic K, Alvarado D, Schmitz KR, Kenniston JA, Mendrola JM, Ferguson KM, Lemmon MA "Comparison of Saccharomyces cerevisiae F-BAR Domain Structures Reveals a Conserved Inositol Phosphate Binding Site", Structure 23(2), 352-363 (2015)
  39. Moustafa IM, Uchida A, Wang Y, Yennawar N, Cameron CE, "Structural models of mammalian mitochondrial transcription factor B2," Biochim Biophys Acta 1849(8), 987-1002 (2015)
  40. Moustafa IM, Gohara DW, Uchida A, Yennawar N, and Cameron CE. "Conformational Ensemble of the Poliovirus 3CD Precursor Observed by MD Simulations and Confirmed by SAXS: A Strategy to Expand the Viral Proteome?". Viruses, 7(11), 5962-5986, (2015)
  41. Muñoz-Escobar J, Matta-Camacho E, Kozlov G and Gehring K. "The MLLE Domain of the Ubiquitin Ligase UBR5 Binds to Its Catalytic Domain to Regulate Substrate Binding". The Journal of Biological Chemistry, 290, 22841-22850, (2015)
  42. Organtini LJ, Allison AB, Lukk T, Parrish CR, Hafenstein S, "Global displacement of canine parvovirus by a host-adapted variant: A structural comparison between pandemic viruses with distinct host ranges," J Virol. 89(3), 1909-12 (2015).
  43. Orlando BJ, Lucido MJ, Malkowski MG. "The structure of ibuprofen bound to cyclooxygenase-2". Journal of Structural Biology, v 189, 1, pp 62–66, (2015)
  44. Pinard MA, Aggarwal M, Mahon BP, Tuc C, and McKenna R. "A sucrose-binding site provides a lead towards an isoform-specific inhibitor of the cancer-associated enzyme carbonic anhydrase IX". Acta Crystallographica Section F, v 71, 10, pp 1352-1358, (2015)
  45. Pinard MA, Lotlikar SR, Boone CD, Vullo D, Supuran CT, Patrauchan MA, McKenna R. "Structure and inhibition studies of a type II beta-carbonic anhydrase psCA3 from Pseudomonas aeruginosa". Bioorganic & Medicinal Chemistry, v 23, 15, pp 4831–4838, (2015)
  46. Price IR, Gaballa A, Ding F, Helmann JD, Ke A. "Mn2+-Sensing Mechanisms of yybP-ykoY Orphan Riboswitches". Molecular Cell, v 57, 6, pp 1110–1123, (2015)
  47. Ranaivoson FM, Liu Q, Martini F, Bergami F, Von Daake S, Li S, LeeD, Demeler B, Hendrickson WA, Comoletti D. "Structural and Mechanistic Insights into the Latrophilin3-FLRT3 Complex that Mediates Glutamatergic Synapse Development". Structure, v 23, 9, pp 1665–1677, (2015)
  48. Shinsky SA and Cosgrove MS. "Unique Role of the WD-40 Repeat Protein 5 (WDR5) Subunit within the Mixed Lineage Leukemia 3 (MLL3) Histone Methyltransferase Complex". The Journal of Biological Chemistry 290, 25819-25833, (2015)
  49. Sircar R, Borbat PP, Lynch MJ, Bhatnagar J, Beyersdorf MS, Halkides CJ, Freed JH, Crane BR. "Assembly States of FliM and FliG within the Flagellar Switch Complex". Journal of Molecular Biology, v 427, 4, 867–886, *2015)
  50. Tang S, Henne MW, Borbat PP, Buchkovich NJ, Freed JH, Mao Y, Fromme CJ, Emr SD. "Structural basis for activation, assembly and membrane binding of ESCRT-III Snf7 filaments". eLIFE, (2015)
  51. Teng Y, Jing H, Aramsangtienchai P, He B, Khan S, Hu J, Lin H, Hao Q, "Efficient Demyristoylase Activity of SIRT2 Revealed by Kinetic and Structural Studies", Scientific Reports 5 (2015)
  52. Tondnevis F, Gillilan R, Bloom L, McKenna R, "Solution study of the Escherichia coli DNA polymerase III clamp loader reveals the location of the dynamic ?? heterodimer," Structural Dynamics 2(054701), (2015)
  53. Wang O, Vogan EM, Nocka LM, Rosen CE, Zorn JA, Harrison SC, John Kuriyan. "Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate". eLife 2015;4:e06074, (2015)
  54. Wong K, Kozlov G, Zhang Y and Gehring K. "Structure of the Legionella Effector, lpg1496, Suggests a Role in Nucleotide Metabolism". The Journal of Biological Chemistry 290, 24727-24737, (2015)
  55. Yang Y, Ye Q, Jia Z and Côté GP. "Characterization of the Catalytic and Nucleotide Binding Properties of the a-Kinase Domain of Dictyostelium Myosin-II Heavy Chain Kinase A". The Journal of Biological Chemistry, 290, 23935-23946, (2015)

Ph.D. Theses

  1. Barnett G, "Mechanistic insights into the role of protein interactions on the aggregation behavior of anti-streptavidin immunoglobulin gamma-1," Ph.D. Thesis, University of Delaware, Advisor: Christopher J Roberts (2015).
  2. Boock JT, "Expanding the capabilities of a bacterial quality control mechanism for engineering enzymes", Ph.D. Thesis, Cornell University, Advisor: Matthew P DeLisa (2015).
  3. Paradise P, "In-situ diffraction studies of rate dependence of twinning, phase transformation, and slip in shape memory alloys", Ph.D. Thesis, Colorado School of Mines, Advisor: Aaron P Stebner (2015).
  4. Pinard MA, "Structure, catalytic mechanism and inhibition of a type II beta carbonic anhydrase psCA3 from Pseudomonas aeruginosa", Ph.D. Thesis, University of Florida, Advisor: Robert McKenna (2015).

 

Videos

  1. WebsEdgeEducation, "Cornell High Energy Synchrotron Source," YouTube, Web. 27 Feb. 2015," YouTube, Web. 24 Aug. 2016.

2014

  1. Bastos-Aristizabal S, Kozlov G, Gehring K, "Structure of the substrate-binding b' domain of the Protein Disulfide Isomerase-Like protein of the Testis", Sci Rep., doi: 10.1038/srep04464., PMID: 24662985 4, 4464 (2014).
  2. Bastos-Aristizabal S, Kozlov G, Gehring K, "Structural insight into the dimerization of human protein disulfide isomerase," Protein Sci. 23(5), 618-26 (2014).
  3. Basu RS, Warner BA, Molodtsov V, Pupov D, Esyunina D, Fernández-Tornero C, Kulbachinskiy A, Murakami KS, "Structural basis of transcription initiation by bacterial RNA polymerase holoenzyme," J Biol Chem 289(35), 24549-59 (2014).
  4. Bhardwaj A, Casjens SR, Cingolani G, "Exploring the atomic structure and conformational flexibility of a 320 Å long engineered viral fiber using X-ray crystallography," Acta Crystallogr D Biol Crystallogr 70(2), 342-53 (2014).
  5. Bollini M, Frey KM, Cisneros JA, Spasov KA, Das K, Bauman JD, Arnold E, Anderson KS, Jorgensen WL, "Extension into the entrance channel of HIV-1 reverse transcriptase-crystallography and enhanced solubility," Bioorg Med Chem Lett 23(18), 5209-12 (2014).
  6. Boscia AL, Treece BW, Mohammadyani D, Klein-Seetharaman J, Braun AR, Wassenaar TA, Klösgen B, Tristram-Nagle S, "X-ray structure, thermodynamics, elastic properties and MD simulations of cardiolipin/dimyristoylphosphatidylcholine mixed membranes", Chem Phys Lipids., doi: 10.1016/j.chemphyslip.2013.12.010 178, 1-10 (2014).
  7. Chatterjee D, Cooley R B, Boyd CD, Mehl R A, O'Toole G A, Sondermann H, "Mechanistic insight into the conserved allosteric regulation of periplasmic proteolysis by the signaling molecule cyclic-di-GMP." Elife (2014).
  8. Das K, Martinez S E, Bandwar R P, Arnold E, "Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage." Nucleic Acids Res 42(12), 8125-37 (2014).
  9. Degen D, Feng Y, Zhang Y, Ebright K Y, Ebright Y W, Gigliotti M, Vahedian-Movahed H, Mandal S, Talaue M, Connell N, Arnold E, Fenical W, Ebright R H, "Transcription inhibition by the depsipeptide antibiotic salinamide A." Elife 3 (2014).
  10. Gruner, S M, "Expanding the femtosecond crystallography toolkit." PNAS U S A 111(48), 16986-7 (2014).
  11. Gupta K, Contreras L M, Smith D, Qu G, Huang T, Spruce L A, Seeholzer S H, Belfort M, Van Duyne G D, "Quaternary arrangement of an active, native group II intron ribonucleoprotein complex revealed by small-angle X-ray scattering." Nucleic Acids Res., doi: 10.1093/nar/gku140 42(8), 5347-5360 (2014).
  12. Heim K P, Crowley P J, Long J R, Kailasan S, McKenna R, Brady L J, "An intramolecular lock facilitates folding and stabilizes the tertiary structure of Streptococcus mutans adhesin P1." Proc Natl Acad Sci U S A 111(44), 15746-51 (2014).
  13. Heymann M, Opthalage A, Wierman J L, Akella S, Szebenyi D M, Gruner S M, Fraden S, "Room-temperature serial crystallography using a kinetically optimized microfluidic device for protein crystallization and on-chip X-ray diffraction." IUCrJ 1(5), 349-60 (2014).
  14. Hsu F, Luo X, Qiu J, Teng Y B, Jin J, Smolka M B, Luo Z Q, Mao Y, "The Legionella effector SidC defines a unique family of ubiquitin ligases important for bacterial phagosomal remodeling." Proc Natl Acad Sci U S A. 111(29), 10538-10543 (2014).
  15. Huo Y, Nam K H, Ding F, Lee H, Wu L, Xiao Y, Farchione M D Jr, Zhou S, Rajashankar K, Kurinov I, Zhang R, Ke A, "Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation." Nat Struct Mol Biol. (2014).
  16. Jun S H, Hirata A, Kanai T, Santangelo T J, Imanaka T, Murakami K S, "The X-ray crystal structure of the euryarchaeal RNA polymerase in an open-clamp configuration." Nat Commun 5, 5132 (2014).
  17. Kang HJ, Paterson NG, Kim CU, Middleditch M, Chang C, Ton-That H, Baker EN, "A slow-forming isopeptide bond in the structure of the major pilin SpaD from Corynebacterium diphtheriae has implications for pilus assembly", Acta Cryst., D 70, 1190-1201 (2014).
  18. Kozlov G, Vinaik R, Gehring K, "Triosephosphate isomerase is a common crystallization contaminant of soluble His-tagged proteins produced in Escherichia coli", Acta Crystallogr Sect F Struct Biol Cryst Commun., doi: 10.1107/S1744309113010841, PMID: 23695562 69(Pt 5), 499-502 (2014).
  19. Lima E, Chushkin Y, van der Linden P, Kim CU, Zontone F, Carpentier P, Gruner SM, Pernot P, "Cryogenic x-ray diffraction microscopy utilizing high-pressure cryopreservation," Phys Rev E Stat Nonlin Soft Matter Phys., PMID: 25375529 90(4-1), 042713 (2014).
  20. Liu CT, Layfield JP, Stewart RJ 3rd, French JB, Hanoian P, Asbury JB, Hammes-Schiffer S, Benkovic SJ, "Probing the electrostatics of active site microenvironments along the catalytic cycle for Escherichia coli dihydrofolate reductase," J Am Chem Soc 136(29), 10349-60 (2014).
  21. Martinez M, Ahmed AH, Loh AP, Oswald RE, "Thermodynamics and mechanism of the interaction of willardiine partial agonists with a glutamate receptor: implications for drug development," Biochemistry 53(23), 3790-5 (2014).
  22. Merz GE, Borbat PP, Pratt AJ, Getzoff ED, Freed JH, Crane BR, "Copper-based pulsed dipolar ESR spectroscopy as a probe of protein conformation linked to disease states," Biophys J 107(7), 1669-74 (2014).
  23. Mikals K, Nam HJ, Van Vliet K, Vandenberghe LH, Mays LE, McKenna R, Wilson JM, Agbandje-McKenna M, "The structure of AAVrh32.33, a novel gene delivery vector," J Struct Biol 186(2), 308-17 (2014).
  24. Organtini LJ, Allison AB, Lukk T, Parrish CR, Hafenstein S, "Global displacement of canine parvovirus by a host-adapted variant: A structural comparison between pandemic viruses with distinct host ranges," J Virol., PMID: 25410876 (2014).
  25. Organtini LJ, Makhov AM, Conway JF, Hafenstein S, Carson SD, "Kinetic and structural analysis of coxsackievirus B3 receptor interactions and formation of the A-particle," J Virol. 88(10), 5755-65 (2014).
  26. Orlando BJ, Lucido MJ, Malkowski MG, "The structure of ibuprofen bound to cyclooxygenase-2," J Struct Biol 189(1), 62-6 (2014).
  27. Paczkowski JE, Fromme JC, "Structural basis for membrane binding and remodeling by the exomer secretory vesicle cargo adaptor," Dev Cell 30(5), 610-24 (2014).
  28. Patel D, Bauman JD, Arnold E, "Advantages of crystallographic fragment screening: Functional and mechanistic insights from a powerful platform for efficient drug discovery," Prog Biophys Mol Biol 116(2-3), 92-100 (2014).
  29. Pradhan L, Gopal S, Nam H-J, "Crystallization and preliminary X-ray analysis of the cardiac transcription factor complex of NKX2.5 and TBX5 with DNA", Acta Cryst., F 70, 592-595 (2014).
  30. Ptak CP, Hsieh CL, Weiland GA, Oswald RE, "Role of stoichiometry in the dimer-stabilizing effect of AMPA receptor allosteric modulators", ACS Chem Biol., doi: 10.1021/cb4007166 9(1), 128-33 (2014).
  31. Sagong HY, Bauman JD, Patel D, Das K, Arnold E, LaVoie EJ, "Phenyl substituted 4-hydroxypyridazin-3(2H)-ones and 5-hydroxypyrimidin-4(3H)-ones: inhibitors of influenza A endonuclease," J Med Chem. 57(19), 8086-98 (2014).
  32. Saliba M, Tan KW, Sai H, Moore DT, Scott T, Zhang W, Estroff LA, Wiesner U, Snaith HJ, "Influence of Thermal Processing Protocol upon the Crystallization and Photovoltaic Performance of Organic–Inorganic Lead Trihalide Perovskites", J. Phys. Chem. C, Article ASAP DOI: 10.1021/jp500717w (2014).
  33. Sasaki E, Zhang X, Sun HG, Lu MY, Liu TL, Ou A, Li JY, Chen YH, Ealick SE, Liu HW, "Co-opting sulphur-carrier proteins from primary metabolic pathways for 2-thiosugar biosynthesis," Nature 510(7505), 427-31 (2014).
  34. Skou M, Skou S, Jensen TG, Vestergaard B, Gillilan RE, "In situ microfluidic dialysis for biological small-angle X-ray scattering," J Appl Crystallogr 47(4), 1355-1366 (2014).
  35. Skou S, Gillilan RE, Ando N, "Synchrotron-based small-angle X-ray scattering of proteins in solution," Nat Protoc 9(7), 1727-39 (2014).
  36. Wedekind J, Liberman J, Jenkin J, Salim M, "Metal Dependence of Ligand Binding and Heavy-Atom Derivatization of Evolutionarily Distinct PreQ 1 Riboswitches," Chemical Biology of Nucleic Acids (2014).
  37. Weiskoff AM, Fromme JC, "Distinct N-terminal regions of the exomer secretory vesicle cargo Chs3 regulate its trafficking itinerary," Front Cell Dev Biol 2(47) (2014).
  38. Yearley EJ, Godfrin PD, Perevozchikova T, Zhang H, Falus P, Porcar L, Nagao M, Curtis JE, Gawande P, Tain R, Zarraga IE, Wagner NJ, Liu Y, "Observation of Small Cluster Formation in Concentrated Monoclonal Antibody Solutions and Its Implications to Solution Viscosity", Biophysical Journal 106(8), 1763-1770 (2014).
  39. Zhang S, Liua X, Barreto-Ortiz SF, Yu Y, Ginn BP, DeSantis NA, Hutton DL, Grayson WL, Cui FZ, Korgel BA, Gerecht S, Mao HQ, "Creating polymer hydrogel microfibres with internal alignment via electrical and mechanical stretching", Biomaterials 35(10), 3243–3251 (2014).
  40. Zhang Y, Degen D, Ho MX, Sineva E, Ebright KY, Ebright YW, Mekler V, Vahedian-Movahed H, Feng Y, Yin R, Tuske S, Irschik H, Jansen R, Maffioli S, Donadio S, Arnold E, Ebright RH, "GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides," Elife (2014).

 

Ph.D. Theses

  1. Gee KO, "Characterization of transcriptional activators in the fungal circadian clock," Ph.D. Thesis, Cornell University, Advisor: Brian R. Crane (2014).
  2. Heymann M, "Microfluidic tools to investigate protein crystallization," Ph.D. Thesis, Brandeis University, Advisor: Seth Fraden (2014).
  3. Kopp MC, "Structural studies of sulfur transfer in thiocarboxylate-dependent methionine biosynthesis," Ph.D. Thesis, Cornell University Advisor: Steven Ealick (2014).
  4. Liberman JA, "Structural and Functional Analysis of Gene Regulatory PreQ 1 Riboswitches," Ph.D. Thesis, University of Rochester, Advisor: Joseph E. Wedekind (2014).
  5. Payne TM, "Crystallographic and spectroscopic studies on the complex of Cytochrome c Peroxidase and Cytochrome c," Ph.D. Thesis, Cornell University, Advisor: Brian Crane (2014).
  6. Toulabi LB, "Identification and structural characterization of a Legionella Phosphoinositide phosphatase," Ph.D. Thesis, Cornell University, Advisor: Yuxin Mao (2014).

 

Videos

  1. WebsEdgeEducation, "MacCHESS, Cornell University - Advancing the Research Goals...," YouTube, Web. 15 Feb. 2014.

2013

  1. Govindasamy L., Dimattia M. A., Gurda B. L., Halder S., McKenna R., Chiorini J. A., Muzyczka N., Zolotukhin S., and Agbandje-McKenna M. Structural insights into Adeno-associated virus serotype 5. J. Virol., doi: 10.1128/JVI.00867-13, 2013
  2. Halder S., Nam H. J., Govindasamy L., Vogel M., Dinsart C., Salomé N., McKenna R., and Agbandje-McKenna M. Structural Characterization of H-1 Parvovirus: Comparison of Infectious Virions to Empty Capsids. J. Virol. 87(9), 5128-5140, 2013
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  7. Zhou Y., Johnson J., Cerione R., and Erickson J. Prenylation and Membrane Localization of Cdc42 Are Essential for Activation by DOCK7. Biochemistry, 52(25), 4354-4363, 2013
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  24. Zhou Y. Y, Zhang H. M., He B., Du J. T., H. N. Lin, Cerione R. A., Hao Q. The Bicyclic Intermediate Structure Provides Insights into the Desuccinylation Mechanism of Human Sirtuin 5 (SIRT5). JBC 287, 28307-28314, 2013
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2012

  1. DiMattia M. A., Nam J-J., Van Vliet K., Mitchell M., Bennett A., Gurda B. L., McKenna R., Olson N. M., Sinovits R. S., Potter M., Byrne B. J., Aslanidi G., Zolotukhin S., Muzyczka N., Baker T. S., Agbandje-McKenna M. Structural Insight into the Unique Properties of Adeno-Associated Virus Serotype 9. J. of Virology, 86(19), 6947-6958, 2012
  2. Das K., Martinez S. E., Bauman J. D., Arnold E. HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism. Nat. Struct. Mol. Biol., 19(2), 253-9, 2012
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  4. Nady N., Krichevsky L., Zhong N., Duan S., Tempel W., Amaya M. F., Ravichandran M., Arrowsmith C. H. Histone Recognition by Human Malignant Brain Tumor Domains. JMB, in press, 2012
  5. Sheng Y., Hong J. H., Doherty R., Srikumar T., Shloush J., Avvakumov G. V., Walker J. R., Xue S., Neculai D., Wan J. W., Kim S. K., Arrowsmith C. H., Raught B., Dhe-Paganon S. A Human Ubiquitin Conjugating Enzyme (E2)-HECT E3 Ligase Structure-function Screen. Molecular & Cellular Proteomics 11, 329-341, 2012
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  7. Hao G-F., Wang F., Li H., Zhu X-L., Yang W-C., Huang L-S., Wu J-W., Berry E. A., Yang G-F. Computational Discovery of Picomolar Qo Site Inhibitors of Cytochrome bc1 Complex. J. Am. Chem. Soc., 134(27), 11168-11176, 2012
  8. Celic A. S., Petri E. T., Benbow J., Hodsdon M. E., Ehrlich B. E., Boggon T. J. Calcium-induced Conformational Changes in C-terminal Tail of Polycystin-2 Are Necessary for Channel Gating. JBC, 287, 17232-17240, 2012
  9. Singh G., Ramachandran S., Cerione R. A. A Constitutively Active Ga Subunit Provides Insights into the Mechanism of G Protein Activatino. Biochemistry, 51(15), 3232-3240, 2012
  10. Singh G., Ramachandran S., Cerione R. A. A Constitutively Active Ga Subunit Provides Insights into the Mechanism of G Protein Activatino. Biochemistry, 51(15), 3232-3240, 2012
  11. Briegel A., Li X., Bilwes A. M., Hughes K. T., Jensen G. J., Crane B. R. Bacterial chemoreceptor arrays are hexagonally packed trimers of receptor dimers networked by rings of kinase and coupling proteins. PNAS USA, PMCID: PMC3309718, 109(10), 3766-71, 2012
  12. Dharmarajan V., Lee J-H., Patel A., Skalnik D. G., Cosgrove M. S. Structural basis for SET1 family Win motif recognition by WDR5. JBC, 10, 287(33), 27275-89, 2012
  13. Rao J. N., Rivera-Santiago R., Li X. E., Lehman W., Dominguez R. Structural analysis of smooth muscle tropomyosin á and â isoforms. JBC, PMCID: PMC3270971, 287(5), 3165-74, 2012
  14. Khan I., Gillilan R., Kriksunov I., Williams R., Zipfel W. R., Englich U. Confocal microscopy on the beamline: novel three-dimensional imaging and sample positioning. J. Appl. Cryst., PMID:22997474 45, 936-943, 2012
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  16. Gulerez I. E., Kozlov G., Rosenauer A., Gehring K. Structure of the third catalytic domain of the protein disulfide isomerase ERp46. Acta Crystallographica, Section F, 68, 2012
  17. Matta-Camacho E., Kozlov G., Menade M., Gehring K. Structure of the HECT C-lobe of the UBR5 E3 ubiquitin ligase. Acta Crystallography, F, Struct Biol Cryst Commun. 88(pt 10), 1158-63, 2012
  18. Saffaee N., Kozlov G., Noronha A. M., Xie J., Wilds C. J., Gehring K. Interdomain Allostery Promotes Assembly of the Poly(A) mRNA Complex with PABP and eIF4G. Mol Cell 48(3), 375-86, 2012
  19. Krasnoff S. B., Englich U., Miller P. G., Shuler M. L., Glahn R. P., Donzelli B. G., Gibson D. M. Metacridamides A and B, Macrocycles from Conidia of the Entomopathogenic Fungus Metarhizium acridum. J. Nat Prod., PMCID: PMC3293398, 75(2), 175-80, 2012
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  23. Zhu A. Y., Zhou Y., Khan S., Deitsch K. W., Hao Q., Lin H. Plasmodium falciparum Sir2A Preferentially Hydrolyzes Medium and Long Chain Fatty Acyl Lysine. ACS Chem. Biol, 7(1), 155-159, 2012
  24. Currie M. A., Adams J. J., Faucher F., Bayer E. A., Jia Z., Smith S. P. Scaffoldin Conformation and Dynamics Revealed by a Ternary Complex from the Clostridium thermocellum Cellulosome. JBC, 287, 26953-26961, 2012
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  26. Nam K. H., Huang Q., Ke A. Nucleic acid binding surface and dimer interface revealed by CRISPR-associated CasB protein structures. FEBS Lett, 586(22), 3956-61, 2012
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  32. Ahmed A. H., Hamada M., Shinada T., Ohfune Y., Weerasinghe L., Garner P. P., Oswald R. E.  The structure of (-)-kaitocephalin bound to the ligand binding domain of the AMPA/glutamate receptor, GluA2. JBC, 287, 41007-41013, 2012
  33. Holley S. M., Ahmed A. H., Srinivasan J., Murthy S. E., Weiland G. A., Oswald R. E., Nowak L. M. The Loss of an Electrostatic Contact Unique to AMPA Receptor Ligand Binding Domain 2 Slows Channel Activation. Biochemistry 51(19), 4015-4027, 2012
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  39. Sarachan K. L., Valentine K. G., Gupta K., Moorman V. R., Gledhill J. M. Jr., Bernens M., Tommos C., W and AJ, Van Duyne G. D. Solution structure of teh core SMN-Germin2 complex. Biochemistry, 445(3), 361-70 2012
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  41. Oot R. A., Wilkens S. Subunit interactions at the V1-Vo interface in the yeast vacuolar ATPase. JBC, PMID: 22367203, 287, 13396-13406, 2012
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2011

  1. Nam H. J., Gurda B. L, McKenna R., Potter M., Byrne B., Salganik M., Muzyczka N., Agbandje-McKenna M. Structural studies of adeno-associated virus serotype 8 capsid transitions associated with endosomal trafficking. J. Virol, 85(22), 11791-9, 2011
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  3. Das K., Bauman J. D., Rim A. S., Dharia C., Clark A. D. Jr., Camarasa M. J., Balzarini J. and Arnold E. "Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. J. Med. Chem, PMID: 21446702 54, 2727-2737, 2011
  4. Ramachandran S., Cerione R. A. A dominant-negative Galpha mutant that traps a stable rhodopsin-Galpha-GTP-betagamma complex. JBC, PMCID: PMC3069470 286(14), 12702-12711, 2011
  5. Wu X., Ramachandran S, Lin M. C., Cerione R. A., Erickson J. W. A minimal Rac activation domain in the unconventional guanine nucleotide exchange factor Dock180. Biochemistry, PMCID: PMC3048587 50(6), 1070-1080, 2011
  6. Xie Q., Lerch T. F, Meyer N. L, Chapman M. S. Structure-function analysis of receptor-binding in adeno-associated virus serotype 6 (AAV-6). Virology, 420(1), 10-9, 2011
  7. Bush D. J., Kirillova O., Clark S. A., Davulcu O., Fabiola F., Xie Q., Somasundaram T., Ellington W. R. and Chapman M. S. The Structure of Lombricine Kinase: Implications for Phosphagen Kinase Conformational Changes. JBC, 286, 9338-9350, 2011
  8. Olia A. S., Prevelige P. E. Jr, Johnson J. E., Cingolani G. Three-dimensional structure of a viral genome-delivery portal vertex. Nat. Struct. Mol. Biol., PMCID:PMC3087855 18(5), 597-603, 2011
  9. Roy A., Bhardwaj A. and Cingolani G. Crystallization of the nonameric small terminase subunit of bacteriophage P22. Acta Crystallographica, F, 67, 1, 104-110, 2011
  10. Cingolani G., Duncan T. M. Structure of the ATP synthase catalytic complex (F(1)) from Escherichia coli in an autoinhibited conformation. Nat. Struct. Mo.l Biol. PMCID: PMC3109198 18(6), 701-7, 2011
  11. Park S. Y., Ham S. W., Kim K. Y., Crane B. R. Crystallization and preliminary X-ray crystallographic analysis of Escherichia coli CheA P3 dimerization domain. Acta Cryst. F, 67(Pt 6), 662-4, 2011
  12. Paul K., Gonzalez-Bonet G., Bilwes A. M., Crane B. R., Blair D. Architecture of the Flagellar Rotor. EMBO J 30, 2962-2971, 2011
  13. Namgoong S., Boczkowska M., Glista M. J., Winkelman J. D., Rebowski G., Kovar D. R., Dominguez R. Mechanism of actin filament nucleation by Vibrio VopL and implications for tandem W domain nucleation. Nat. Struct. Mol. Biol. 18(9), 1060-7, 2011
  14. Nageswara Rao J., Rivera-Santiago R., Li X. E., Lehman W., Dominguez R. Structural analysis of smooth muscle tropomyosin alpha and beta isoforms. JBC, PMID: 22119916 epub, 2011
  15. Ando N., Brignole E. J., Zimanyi C. M., Funk M. A., Yokoyama K., Asturias F. J., Stubbe J., Drennan C. L. Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase. PNAS USA, PMCID: PMC3248520, 108(52), 21046-51, 2011
  16. Hazra A. B., Han Y., Chatterjee A., Zhang Y., Lai R. Y., Ealick S. E., Begley T. P. A missing enzyme in thiamin thiazole biosynthesis: identification of TenI as a thiazole tautomerase. J. Am. Chem. Soc., 133(24), 9311-9, 2011
  17. Fenwick M. K., Philmus B., Begley T. P. and Ealick S. E. Toxoflavin Lyase Requires a Novel 1-His-2-Carboxylate Facial Triad. Biochemistry, 50, 6, 1091-1100, 2011
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