Grades 9-12: In this lab, students predict an amino acid sequence from the DNA that codes for it and then predict the shape of an enzyme given the substrate it binds with.
EVOLUTION, GENETICS & MOLECULAR BIOLOGY (Grades 5-12)
The shape of a protein determines its function. In this lab, students will be given a hypothetical DNA sequence for part of an enzyme. Using the Universal Genetic Code, they will then determine the amino acid sequence coded for by the DNA. Students will then examine a “substrate” and predict the shape of an enzyme that could interact with that substrate. Differently shaped Lego® blocks will represent different amino acids. Next, they will construct the “enzyme” using Lego®s as specified in the code and see if it a) matches their prediction and b) fits the substrate. Effects of mutant DNA sequences on the enzyme structure will be examined to see how the interaction between the enzyme and substrate are affected.
Students use Lego® pieces from this kit to illustrate the lock-and-key model of enzymes and how mutations can affect the shape of an enzyme.
The kit includes:
- 24 bags with Lego® pieces. Each bag contains:
- 1 – 1×1 piece
- 4 – 2×1 pieces
- 2 – 3×1 pieces
- 2 – 4×1 pieces
- 1 – 6×1 piece
- 1 – ‘L’ piece
- 1 – 2 x 2 piece
- 1 – 4 x 2 sheet
- 1 – ‘roof piece’
- 1 – completed substrate
- Container & extra pieces
- 5 completed (glued) enzymes (wild type and 4 mutants)
- 12 laminated ‘The Blueprint’ sheets
- 12 laminated ‘Genetic Code and Lego® Code’ sheets
- Lab manual
Teachers must supply:
- Colored pencils
HOW TO RESERVE
To request this kit, please complete our reservation form. This form includes details on equipment shipping, reservation logistics, and required training.