BioSAXS / HP BioSAXS Beamline

Biomolecular structure from solution
High-pressure studies in biophysics
Deep Life
Food Science

high pressure

Beamline ID7A1

 

Description:

Biomolecular structure from solution
High-pressure studies in biophysics
Deep life, i.e. organisms living under high pressure
Food science

Lead Scientist:

Richard Gillilan (Lead); Qingqui Huang

Anticipated availability of beamline capabilities:

High-throughput SAXS/WAXS, chromatography coupled SAXS (SEC-SAXS, AEX-SAXS), inline DLS/MALS, high-pressure SAXS (static sample to 400 MPa), high-pressure SEC-SAXS (100 MPa), mail-in program.

Photon Energy Range:

7-14 keV at 1.5% bandwidth
q = 0.006 - 0.7 Å-1 

Energy Resolution:

1.5% bandwidth

Spot size:

250 micron (h) x 200 micron (v) or 25 micron (h) x 30 micron (v) (focused at x125 gain)
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BioSAXS beamline

BioSAXS at MacCHESS

Biological Small Angle X-ray Solution Scattering (BioSAXS)
is a popular method that yields valuable structural
HPT: HP-BioSAXS:HP-SAXS cell

High Pressure BioSAXS

Pressure is a fundamental thermodynamic parameter that affects the free energy of a system. For macromolecules in solution, this often results in changes in molecular structure.