Biological Small Angle X-ray Solution Scattering (BioSAXS) is a popular method that yields valuable structural information from solutions of biomolecules. MacCHESS maintains a state-of-the-art BioSAXS facility with automated sample loading, in-line chromatography, and specialized setups for time-resolved and high-pressure measurements. We offer annual training workshops and maintain the widely-used open-source data processing software RAW.

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The basic idea behind small angle X-ray solution scattering is simple: shine a beam of X-rays on a droplet of protein solution and measure how much the rays get deflected.

The basic idea behind small angle X-ray solution scattering is simple: shine a beam of X-rays on a droplet of protein solution and measure how much the rays get deflected.

The basic idea behind small angle X-ray solution scattering is simple: shine a beam of X-rays on a droplet of protein solution and measure how much the rays get deflected.

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MacCHESS is the home of the widely-used BioSAXS data analysis package RAW. The program is free, open-source, and runs on Mac, Windows, and Linux.

Almost all BioSAXS at MacCHESS is done on G1 station, except during the annual BioSAXS Essentials course when we also use F1 station.

We strongly recommend reading these recently published guidelines: