Structural insight into HIV reverse transcriptase
Jeffrey DeStefano, an HIV researcher at the University of Maryland, College Park and post-doc Gauri Nair published a paper in 2008 about their development of a new inhibitor of HIV RT (reverse transcriptase), the viral enzyme which copies viral RNA into DNA in order that it might be incorporated into the host cell's chromosomes by another viral enzyme, integrase (3). The RT inhibitor consisted of a 38 base pair piece of DNA with a particular sequence which binds tightly to the enzyme.