A CHESS first - Resonant X-ray Inelastic Scattering (RIXS) study published in JACS
Trifluoromethyl (CF3) substituents profoundly influence properties of organic molecules and transition metal complexes. Medicinal chemists have recognized the value of the CF3 group for advantageous drug properties including increased physiological longevity, facile blood−brain barrier penetration, and enhanced protein−substrate binding affinities. Consequently, developing reactions that install CF3 on organic frameworks is a major research goal.