Crystallography and solution scattering join forces in the study of antibiotic synthesis
Surprisingly, cells also have a completely alternate means of producing small special-purpose polypeptides which act as antibiotics or various other environmentally-friendly compounds of therapeutic importance. Instead of the ribosome, cells use a very large protein complex called nonribosomal peptide synthetase (NRPS) to produce these compounds. Like a molecular assembly line, the different subunits of an NRPS each perform a critical step in the process and, using moving parts, hand off the product to the next domain.