The dedicated High Magnetic Field (HMF) X-ray Beamline at the Cornell High Energy Synchrotron Source (CHESS) will be a world-class high-energy X-ray beam- line. It will feature a custom low-temperature superconducting (LTS) magnet generating continuous fields as high as 20 Tesla. The beamline will be designed to accommodate even higher fields from future magnets, which will become feasible as high temperature superconducting (HTS) magnet technology matures.

Cancer cells often overexpress glutaminase enzymes, in particular glutaminase C (GAC), which resides in the mitochondria and catalyzes the hydrolysis of glutamine to glutamate.  High levels of GAC have been observed in aggressive cancers and the inhibition of its enzymatic activity has been shown to reduce their growth and survival, both in vitro and in mouse models.  Numerous GAC inhibitors have been reported, with the most heavily investigated being a class of compounds derived from the small molecule BPTES (bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide).

What is the new work?

In food products, the natural blues tend to be moody.

A fun food colorant with a scientific name – phycocyanin – provides a vivid blue pigment that food companies crave, but it can be unstable when placed in soft drinks and sport beverages, and then lose its hues under fluorescent light on grocery shelves.

A quick interview with Philip Milner, NSF Early Career Award Recipient
 

What are your research interests?

My research group is broadly interested in the applications of porous crystalline materials, specifically metal-organic and covalent organic frameworks. We are interested in leveraging the unparalleled tunability of these materials for new applications in organic synthesis, medicinal chemistry, chemical separations, and even structural biology through a project in collaboration with CHESS.

Jonathan Clinger, a postdoctoral researcher in the Department of Physics, in the College of Arts and Sciences (A&S), is lead author of the study, which was published Aug. 4 in the journal of the International Union of Crystallography.

What is the new work?

Richard Gillilan, a MacCHESS/CHEXS staff scientist, has been named a member of the 2021 class of Fellows of the American Crystallographic Association (ACA), in recognition of his many career achievements, especially the development of a world-class BioSAXS facility at CHESS.

What is the discovery?

Developing a better understanding of protein folding and unfolding reactions is a significant challenge for structural biology. In a new paper, a team lead by Catherine Royer from Rensselaer Polytechnic Institute reports a high-pressure small-angle x-ray scattering study of the model  protein CTL9-I98A in solution, which allows direct observation of the pressure-induced unfolded state.