High pressure is a tool that can be used to alter the equilibrium population of molecular conformations and associations, both in crystals and in solutions. Pressure-based techniques available at MacCHESS can improve diffraction quality from a crystal, trap a ligand in an active site, and allow protein folding in solution to be followed.
All high pressure work requires advance arrangement with MacCHESS staff.
For High Pressure Cryocooling experiments using crystals, contact Qingqiu Huang.
In some cases, as noted below, experiments will be collaborative efforts and MacCHESS staff will expect to be included as authors on resulting papers.