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CHESS squeezes in an early Users’ Meeting prior to extended shutdown
The annual CHESS Users’ Meeting was held this year on Tuesday, May 15, 2018, earlier than usual due to our upgrade project, CHESS-U, starting this June.
Discovering new drugs to combat microbial resistance to antibiotics
Resistance to antimicrobial agents is a worldwide problem. Not only do bacteria mutate to become resistant, they can acquire resistance genes from other bacteria. Using a structure-based strategy, researchers seek to identify new drugs which can inhibit this transfer and so limit the development of antimicrobial resistance.
“Seriously Sweet!” Ace K binding observed in CA IX
Human carbonic anhydrase IX (CA IX) is an enzyme upregulated in tumorigenic tissue that is being targeted by small molecules as a potential cancer therapy.
Serial microcrystallography at CHESS: Protein crystals on chips enable high throughput
The standard X-ray protein crystallography experiment requires a single protein crystal specimen that is large enough to collect a “complete” data set, that is, to collect all the available diffraction peaks to a given resolution.
CHESS unveils fresh new website
Parallel to the CHESS-U project performing necessary equipment upgrades here at Wilson Lab, the CHESS website was also in the shop for a makeover.
DNA to RNA - more ways than one
Information encoded in our genes controls how we live and grow. As part of this complex process, DNA is transcribed to RNA, one "letter" (nucleotide) at a time, by an enzyme called RNA polymerase (RNAP).
A pioneer of scientific tools
Sol Gruner, known for developing x-ray detectors, is a toolmaker, tackling scientific problems and exploring the unknown.
RAW Power! MacCHESS software brings synchrotron-level data processing to the laptop and home laboratory
Since its introduction by Søren Skou (Nielsen) in 2010, the BioXTAS RAW software has been a familiar interface to the many biomedical scientists collecting data at CHESS beamlines in recent years.