BioSAXS Essentials 8 workshop introduces state-of-the-art density program
In an era when our most detailed pictures of biomolecules come from frozen or crystalline samples, biological small angle X-ray solution scattering (BioSAXS) is more essential than ever as a tool for learning how molecules actually behave under realistic biological conditions in the liquid state.
Discovering new drugs to combat microbial resistance to antibiotics
Resistance to antimicrobial agents is a worldwide problem. Not only do bacteria mutate to become resistant, they can acquire resistance genes from other bacteria. Using a structure-based strategy, researchers seek to identify new drugs which can inhibit this transfer and so limit the development of antimicrobial resistance.
“Seriously Sweet!” Ace K binding observed in CA IX
Human carbonic anhydrase IX (CA IX) is an enzyme upregulated in tumorigenic tissue that is being targeted by small molecules as a potential cancer therapy.
Serial microcrystallography at CHESS: Protein crystals on chips enable high throughput
The standard X-ray protein crystallography experiment requires a single protein crystal specimen that is large enough to collect a “complete” data set, that is, to collect all the available diffraction peaks to a given resolution.
CHESS unveils fresh new website
Parallel to the CHESS-U project performing necessary equipment upgrades here at Wilson Lab, the CHESS website was also in the shop for a makeover.
DNA to RNA - more ways than one
Information encoded in our genes controls how we live and grow. As part of this complex process, DNA is transcribed to RNA, one "letter" (nucleotide) at a time, by an enzyme called RNA polymerase (RNAP).
A pioneer of scientific tools
Sol Gruner, known for developing x-ray detectors, is a toolmaker, tackling scientific problems and exploring the unknown.
RAW Power! MacCHESS software brings synchrotron-level data processing to the laptop and home laboratory
Since its introduction by Søren Skou (Nielsen) in 2010, the BioXTAS RAW software has been a familiar interface to the many biomedical scientists collecting data at CHESS beamlines in recent years.