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![Image description in caption](/sites/default/files/styles/person_thumbnail/public/2022-02/fig1.png?itok=EBLBqLlo)
How two cancer drugs can look the same but behave differently - revealed by serial room temperature crystallography
Many cancer cells require the enzyme glutaminase synthase C (GAC) to grow well. Consequently drugs that inhibit GAC are potential cancer treatments, and much work is being done to find the best ones. The Cerione group reports some of this work.
![""](/sites/default/files/styles/person_thumbnail/public/2018-03/casu_fig1c.png?itok=S4ADjOKm)
Discovering new drugs to combat microbial resistance to antibiotics
Resistance to antimicrobial agents is a worldwide problem. Not only do bacteria mutate to become resistant, they can acquire resistance genes from other bacteria. Using a structure-based strategy, researchers seek to identify new drugs which can inhibit this transfer and so limit the development of antimicrobial resistance.
![RNA, DNA, RNAP](/sites/default/files/styles/person_thumbnail/public/2017-10/murakami_fig2_cut.jpg?itok=dP9VUJGb)
DNA to RNA - more ways than one
Information encoded in our genes controls how we live and grow. As part of this complex process, DNA is transcribed to RNA, one "letter" (nucleotide) at a time, by an enzyme called RNA polymerase (RNAP).
![compound refractive lens](/sites/default/files/styles/person_thumbnail/public/2017-11/compound-refractive-lens.jpg?itok=dYjNIUo4)
Focusing on microbeam: Initial installment of CRLs at CHESS
A great challenge at many x-ray beamlines is to direct x-rays into in a very small, very clean footprint while maintaining high photon flux.
![Chris Fromme](/sites/default/files/styles/person_thumbnail/public/2018-02/chrisfromme_0.jpg?itok=YjBpakWe)
CHESS user awarded Guggenheim Fellowship
Chris Fromme, Cornell Molecular Biology & Genetics, has been awarded a prestigious Guggenheim fellowship for his work in structural biology.
![Ac_VRMA_CHO binding](/sites/default/files/styles/person_thumbnail/public/2018-02/ac-vrma-cho-binding_graphic.jpg?itok=-F0CoWZt)
Surprising mechanism of an enzyme in a membrane
Many cellular processes, particularly intercellular signaling, require enzyme-catalyzed reactions to occur inside a cell membrane.
![fluorescence confocal imaging](/sites/default/files/styles/person_thumbnail/public/2018-02/fluorescence_confocal_imaging_graphic.jpg?itok=-_WdHaC4)
Fluorescence imaging at the MacCHESS A1 and F1 beamlines makes crystal centering easier
Macromolecules typically produce only small crystals; to observe diffraction from them (and determine the molecular structure) we need the intense, highly collimated beam from a synchrotron source.
![Snf7 packing](/sites/default/files/styles/person_thumbnail/public/2018-02/snf7_packing_2.png?itok=wefsBYNe)
Unusually deformable protein crystals
Application of high pressure to crystals of Snf7 has an unusual effect. Cryocooling protein crystals under pressure (HPC) can reduce damage due to the cooling process.