Organisms have evolved to thrive under conditions of extreme pressure in the deepest ocean trenches and deep in the earth’s crust. X-ray crystallography of macromolecules under pressure (HP-MX) offers atomic scale insight into the molecular adaptations of extremophiles to their environment, as well as fundamental insight into the biophysical properties of proteins. This workshop provides an introduction to the field of high pressure biology, crystallography for biophysical research, and the unique high pressure techniques available at CHEXS including HP-SAXS, HP-MX in a diamond anvil cell (DAC), and HP cryo-cooling and gas trapping. Hands-on participants will have the opportunity to collect MX data using the DAC and HP cryo-cooling techniques at CHESS beamline ID7B2.
The agenda is subject to change.